| Identification |
|---|
| BMDB Protein ID
| BMDBP00928 |
| Secondary Accession Numbers
| |
| Name
| Tryptophan--tRNA ligase, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| WARS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity). |
| Pathways
|
- Protein Synthesis: Tryptophan
- Tryptophan Metabolism
|
| Reactions
|
| Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-Tryptophyl-tRNA(Trp) |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| WARS1 |
| Gene Sequence
|
>1428 bp
ATGGCAGACATGTCCAATGGCGAGCAGGGCTGTGGGTCCCCCCTGGAGCTGTTCCACAGC
ATCGCTGCTCAGGGGGAGCTCGTAAGGGACCTCAAAGCCAGAAACGCAGCCAAGGATGAA
ATTGATTCTGCAGTGAAGATGTTGTTGTCCTTAAAAACGAGCTACAAAGCTGCCACAGGG
GAGGATTACAAGGTGGACTGTCCTCCAGGGGACCCGGCGCCTGAGAGTGGTGAGGGCCTG
GATGCCACCGAAGCAGACGAGGACTTTGTGGATCCCTGGACAGTGCAGACAAGCAGCGCC
AAAGGCATTGACTACGACAAGCTCATTGTTCGATTTGGAAGCAGTAAAATTGACAAGGAG
CTGGTAAACCGAATAGAGAGAGCCACGGGCCAGAGACCACACCGCTTCCTGCGCAGGGGA
ATCTTCTTCTCACACAGAGACATGCATCAGATTCTGGATGCCTATGAAAACAAGAAGCCG
TTCTATCTCTACACGGGCAGGGGCCCCTCTTCTGAAGCCATGCATGTGGGTCACCTCATC
CCATTCATCTTCACCAAGTGGCTGCAGGATGTGTTCAACGTCCCCTTGGTCATCCAGATG
ACTGATGACGAGAAGTACCTGTGGAAGGACCTGACCCTGGATCAGGCCTATGGCTACGCT
GTGGAGAACGCCAAGGATATCACGTGCGGCTTTGACATCAACAAAACGTTCATCTTCTCT
GACCTTGACTACATGGGGATGAGCCCTGGCTTCTACAAGAACGTGGTGAAGATCCAGAAG
CACGTCACCTTCAACCAAGTGAAAGGCATTTTCGGCTTCACTGACAGCGACTGCATTGGG
AAGATCAGTTTTCCTGCCATCCAGGCCGCTCCCTCCTTCAGCAACTCATTCCCTCAGATC
TTCCGAGACCGGACGGACGTCCAGTGCCTCATCCCGTGCGCCATCGACCAGGACCCGTAC
TTCAGGATGACCAGGGACGTGGCCCCCAGGATCGGCTACCCCAAGCCAGCCCTCTTGCAC
TCGACCTTCTTCCCTGCCCTGCAGGGGGCCCAGACCAAGATGAGTGCCAGTGACCCCAAC
TCTTCCATCTTCCTCACGGACACGGCCAAGCAGATCAAGACCAAGGTCAACAAGCACGCC
TTCTCCGGAGGCAGGGACACCGTTGAGGAGCACCGGCAGTTTGGGGGCAACTGTGACGTG
GACGTGTCCTTCATGTACCTGACCTTCTTCCTGGAGGATGATGACAAGCTGGAGCAGATC
AGGAGGGACTACACGAGCGGGGCCATGCTCACCGGCGAGCTCAAGAAGGAGCTCATCGAA
GTCCTGCAGCCCTTGATTGCCGAGCACCAGGCCCGGCGCAAGGAGGTCACCGACGAGATC
GTGAAAGAATTCATGACCCCCCGGAAGCTGTCCTACGACTTTCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 476 |
| Molecular Weight
| 53812.0 |
| Theoretical pI
| 5.51 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Tryptophanyl-tRNA synthetase, cytoplasmic
MADMSNGEQGCGSPLELFHSIAAQGELVRDLKARNAAKDEIDSAVKMLLSLKTSYKAATG
EDYKVDCPPGDPAPESGEGLDATEADEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKE
LVNRIERATGQRPHRFLRRGIFFSHRDMHQILDAYENKKPFYLYTGRGPSSEAMHVGHLI
PFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYGYAVENAKDIIACGFDINKTFIF
SDLDYMGMSPGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQ
IFRDRTDVQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDP
NSSIFLTDTAKQIKTKVNKHAFSGGRDTVEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQ
IRRDYTSGAMLTGELKKELIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSYDFQ
|
| External Links |
|---|
| GenBank ID Protein
| CAA37872.1 |
| UniProtKB/Swiss-Prot ID
| P17248 |
| UniProtKB/Swiss-Prot Entry Name
| SYWC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X53918 |
| GeneCard ID
| WARS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
