| Identification |
|---|
| BMDB Protein ID
| BMDBP00944 |
| Secondary Accession Numbers
| None |
| Name
| Platelet-activating factor acetylhydrolase |
| Synonyms
|
Not Available
|
| Gene Name
| PLA2G7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 1-alkyl-2-acetylglycerophosphocholine ester |
| Specific Function
| Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| PLA2G7 |
| Gene Sequence
|
>1335 bp
ATGTTACCGTCCAAATTGCATGCGCTTTTCTGCCTCTGCACCTGCCTTGCACTGGTTTAT
CCTTTTGACTGGCAAGACCTGAATCCAGTTGCCTATATTGAATCACCAGCATGGGTCAGT
AAGATACAAGCTCTGATGGCTGCTGCAAACATTGGTCAATCTAAAATCCCCAGAGGAAAT
GGATCTTATTCCGTCGGTTGTACAGACTTGATGTTTGATTACACTAATAAGGGCACCTTC
TTGCGTTTGTATTATCCATCTCAAGATGATGATCACTCCGACACCCTTTGGATCCCAAAC
AAAGAATATTTTTTGGGTCTTAGTAAATTTCTTGGAACACACTGGCTTGTGGGCAAAATT
ATGGGCTTATTCTTCGGTTCAATGACAACTCCTGCAGCCTGGAATGCACATCTGAGGACT
GGGGAAAAATACCCACTAATTATTTTTTCTCATGGTCTTGGAGCATTCAGGACGATTTAT
TCTGCTATTGGCATTGATCTGGCATCCCACGGGTTTATAGTTGCTGCTGTAGAACACAGG
GATGGCTCTGCATCCTCGACATACTATTTCAAGGACCAGTCTGCTGTAGAAATAGGCAAC
AAGTCTTGGCTCTATCTCAGAACCCTGAAGCGAGGAGAGGAGGAGTTTCCTTTACGAAAT
GAGCAGTTACGGCAACGAGCAAAGGAATGTTCTCAAGCTCTCAGTTTGATTCTGGACATT
GATCACGGGAGGCCAGTGACGAATGTACTAGATTTAGAGTTTGATGTGGAACAGCTGAAG
GACTCTATTGATAGGGATAAAATAGCCATTATTGGACATTCTTTTGGTGGAGCCACAGTT
ATTCAGACTCTTAGTGAAGACCAGAGATTCAGGTGTGGCATTGCTCTGGATGCATGGATG
TTTCCCGTGGGTGATGAAGTATATTCCAGAATTCCTCAACCCCTCTTTTTTATCAACTCG
GAACGATTCCAATACCCTTCTAATATCATAAGAATGAAAAAATGCTTCTTACCTGATAGA
GAACGAAAAATGATTACAATCAGGGGTTCGGTCCATCAGAATTTTGTTGACTTCACTTTT
GCCACTAGCAAAATAATTGGCTACCTATTCACACTGAAAGGAGACATCGATTCCAATGTA
GCCATCAGCCTTAGCAACAAAGCTTCCTTAGCGTTCTTACAAAAACATTTAGGACTTCAG
AAAGATTTTGATCAGTGGGATTCTTTAGTTGAAGGCGAAGATCACAATCTTATTCCAGGG
ACCAACATTAACACAACCAACCACCAAGCCATTCTGCAGAACTCCACAGGAATAGAGAGA
CCAAATTTAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 444 |
| Molecular Weight
| 50133.0 |
| Theoretical pI
| 6.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Platelet-activating factor acetylhydrolase
MLPSKLHALFCLCTCLALVYPFDWQDLNPVAYIESPAWVSKIQALMAAANIGQSKIPRGN
GSYSVGCTDLMFDYTNKGTFLRLYYPSQDDDHSDTLWIPNKEYFLGLSKFLGTHWLVGKI
MGLFFGSMTTPAAWNAHLRTGEKYPLIIFSHGLGAFRTIYSAIGIDLASHGFIVAAVEHR
DGSASSTYYFKDQSAVEIGNKSWLYLRTLKRGEEEFPLRNEQLRQRAKECSQALSLILDI
DHGRPVTNVLDLEFDVEQLKDSIDRDKIAIIGHSFGGATVIQTLSEDQRFRCGIALDAWM
FPVGDEVYSRIPQPLFFINSERFQYPSNIIRMKKCFLPDRERKMITIRGSVHQNFVDFTF
ATSKIIGYLFTLKGDIDSNVAISLSNKASLAFLQKHLGLQKDFDQWDSLVEGEDHNLIPG
TNINTTNHQAILQNSTGIERPNLD
|
| External Links |
|---|
| GenBank ID Protein
| AAC48483.1 |
| UniProtKB/Swiss-Prot ID
| Q28017 |
| UniProtKB/Swiss-Prot Entry Name
| PAFA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U34247 |
| GeneCard ID
| PLA2G7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
