| Identification |
|---|
| BMDB Protein ID
| BMDBP00983 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 T |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2T |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| UBE2T |
| Gene Sequence
|
>588 bp
ATGCAGAGAACATCGCGTCTGAAGCGAGAGCTGAGCCTGCTGGCCGCGGAGCCGCCCCCG
GGCATCACGTGCTGGCAGGATGGGGATCGGATGGAAGACCTGCGAGCGCAGATTCTAGGT
GGAGCCAACACACCTTATGAAAAAGGTGTTTTCAAGCTGGAAGTTCACATTCCAGAGAGG
TACCCATTTGAACCTCCTCAGATCCGATTTCTGACTCCCATCTATCACCCCAACATCGAC
TCTGCGGGACGGATTTGTCTAGATGTTCTCAAGTTGCCACCAAAAGGTGCCTGGAGACCA
TCCCTCAACATCGCAACCCTGCTGACTTGCATTCAGCAGCTCATGGCCGAGCCCAACCCG
GACGACCCGCTCATGGCTGACATCTCCTCAGAGTTTAAATACAACAAGCCAGTCTTCTTC
AAGAACGCCAGGCAGTGGACAGAGAAGCACGCACGGCAGAAGACAGACGAGGAAGGGATG
CCTGGCAGCCTCCCCGAGGTGGGCGGCTCAGAGGGACCCAGCGCCGCACAGAAGAGGAAA
GCTGGGCAGCTGAGCAGCGGTGGAAAGAGGTTTTGCCCTGACGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 195 |
| Molecular Weight
| 21765.0 |
| Theoretical pI
| 8.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 T
MQRTSRLKRELSLLAAEPPPGITCWQDGDRMEDLRAQILGGANTPYEKGVFKLEVHIPER
YPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATLLTCIQQLMAEPNP
DDPLMADISSEFKYNKPVFFKNARQWTEKHARQKTDEEGMPGSLPEVGGSEGPSAAQKRK
AGQLSSGGKRFCPDV
|
| External Links |
|---|
| GenBank ID Protein
| AAI09638.1 |
| UniProtKB/Swiss-Prot ID
| Q32LD2 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2T_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DAAA02043707 |
| GeneCard ID
| UBE2T |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
