| Identification |
|---|
| BMDB Protein ID
| BMDBP01008 |
| Secondary Accession Numbers
| None |
| Name
| Carbonyl reductase family member 4 |
| Synonyms
|
Not Available
|
| Gene Name
| CBR4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones. |
| Pathways
|
- Fatty Acid Biosynthesis
- Lipid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| CBR4 |
| Gene Sequence
|
>714 bp
ATGGACAAGGTGTGCGCCGTGTTCGGAGGCTCCCGGGGCATCGGCAGGGCGGTGGCCCGC
CTGATGGCCCAGAGAGGCTATCGACTGGCCATCGTCGCCCGGAATCTGGAGGGGGCCAGA
GCCGCGGCCGGGGACCTCGGCGGAGACCATTTGGCATTGAGCTGTGATGTTGCCAAAGAA
CATGATGTTCAAAATACATTTGAAGAGATAGAGAAAAATTTAGGTCGCGTTAATTTCTTG
GTAAATGCAGCTGGAATTAACAGGGATAACCTCTTAGTAAGGACAAATACTGAAGATATG
CTCTCTCAGCTCCATACTAACCTCCTGGGCTCCATGCTGACCTGTAGAGCTGCCCTGAAG
ACAATGATTAAACAGCAGAGAGGGTCCATTGTGAATGTAGGAAGTGTTGTTGGTTTAAAA
GGCAATTCCGGCCAGTCTGTATACAGTGCCAGTAAAGGAGGATTAGTCGGATTTTCACGT
GCTCTTGCCAAAGAAGTAGCAAAAAAGAAAATTAGAGTGAATGTAGTTGCACCAGGATTC
ATTCACACAGATATGACAAAAGACTTGAATGAAGAACTTTTAAAGAAGAATATCCCTCTG
GGAAGGTTTGGAGACGCCCTTGACGTGGCCCAGGCAGCCGTATTTCTTCTAGAGTCGCCG
TATGTGACAGGGCACGTCCTGGTGGTGGATGGCGGCCTGCAGCTCACCATGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 237 |
| Molecular Weight
| 25269.0 |
| Theoretical pI
| 9.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Carbonyl reductase 4
MDKVCAVFGGSRGIGRAVARLMAQRGYRLAIVARNLEGARAAAGDLGGDHLALSCDVAKE
HDVQNTFEEIEKNLGRVNFLVNAAGINRDNLLVRTNTEDMLSQLHTNLLGSMLTCRAALK
TMIKQQRGSIVNVGSVVGLKGNSGQSVYSASKGGLVGFSRALAKEVAKKKIRVNVVAPGF
IHTDMTKDLNEELLKKNIPLGRFGDALDVAQAAVFLLESPYVTGHVLVVDGGLQLTM
|
| External Links |
|---|
| GenBank ID Protein
| AAI34483.1 |
| UniProtKB/Swiss-Prot ID
| A4IFA7 |
| UniProtKB/Swiss-Prot Entry Name
| CBR4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC134482 |
| GeneCard ID
| CBR4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
