| Identification |
|---|
| BMDB Protein ID
| BMDBP01022 |
| Secondary Accession Numbers
| |
| Name
| 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase |
| Synonyms
|
Not Available
|
| Gene Name
| HSD3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell wall/membrane/envelope biogenesis |
| Specific Function
| 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. |
| Pathways
|
- Lipid metabolism
- Steroid Biosynthesis
|
| Reactions
|
| 3 beta,7 alpha-Dihydroxy-5-cholestenoate + NAD → 7 alpha-Hydroxy-3-oxo-4-cholestenoate + NADH |
details
|
| 7-a,27-dihydroxycholesterol + NADP → 7 alpha,26-Dihydroxy-4-cholesten-3-one + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q12 |
| SNPs
| HSD3B |
| Gene Sequence
|
>1122 bp
ATGGCAGGGTGGAGCTGCCTCGTGACCGGAGGAGGAGGCTTTCTGGGCCAGAGGATCATC
TGCCTGTTGGTGGAGGAGAAGGATCTGCAGGAAATCCGGGTGCTAGACAAAGTCTTCAGA
CCAGAAGTTCGGGAGGAATTTTCTAAGCTCCAGAGCAAGATCAAGCTGACCCTGCTGGAA
GGAGACATTCTGGATGAGCAGTGCCTGAAGGGGGCCTGCCAGGGCACCTCAGTGGTCATC
CACACCGCCTCTGTCATTGACGTCAGGAATGCTGTCCCGCGAGAGACCATCATGAACGTC
AATGTGAAAGGTACCCAGCTGCTGTTGGAGGCCTGTGTCCAGGCCAGCGTACCGGTCTTT
ATCCACACCAGCACCATAGAAGTGGCTGGGCCCAACTCCTACAGGGAGATCATCCAAGAC
GGCCGTGAAGAAGAGCATCATGAATCGGCATGGTCCTCTCCATACCCATACAGCAAGAAG
CTTGCCGAGAAGGCTGTGCTGGGAGCTAATGGGTGGGCTCTGAAAAATGGTGGCACCTTG
TACACTTGTGCCCTGAGGCCCATGTACATCTACGGGGAGGGGAGCCCATTCCTTTCTGCC
TACATGCACGGAGCCTTGAATAACAACGGCATCCTGACCAATCACTGCAAGTTCTCAAGA
GTCAACCCAGTCTATGTTGGCAATGTGGCCTGGGCCCACATTCTGGCCTTGAGGGCCCTG
AGGGACCCCAAAAAGGTCCCAAACATCCAAGGACAGTTCTACTACATCTCAGACGACACG
CCACACCAAAGCTACGATGACCTCAATTACACTTTGAGCAAAGAATGGGGCTTCTGCCTG
GATTCCCGGATGAGCCTTCCTATTTCTCTGCAGTACTGGCTTGCCTTCCTGCTGGAAATA
GTGAGCTTCCTGCTCAGTCCAATTTACAAATATAACCCTTGCTTCAACCGCCACCTAGTG
ACTCTTTCCAACAGCGTGTTCACCTTCTCCTATAAGAAAGCTCAGCGAGATCTGGGGTAT
GAGCCCCTCTACACTTGGGAGGAAGCCAAGCAGAAAACCAAGGAGTGGATTGGCTCCCTG
GTGAAACAGCACAAAGAGACCCTGAAAACAAAGATTCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 373 |
| Molecular Weight
| 42220.0 |
| Theoretical pI
| 7.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
MAGWSCLVTGGGGFLGQRIICLLVEEKDLQEIRVLDKVFRPEVREEFSKLQSKIKLTLLE
GDILDEQCLKGACQGTSVVIHTASVIDVRNAVPRETIMNVNVKGTQLLLEACVQASVPVF
IHTSTIEVAGPNSYREIIQDGREEEHHESAWSSPYPYSKKLAEKAVLGANGWALKNGGTL
YTCALRPMYIYGEGSPFLSAYMHGALNNNGILTNHCKFSRVNPVYVGNVAWAHILALRAL
RDPKKVPNIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSRMSLPISLQYWLAFLLEI
VSFLLSPIYKYNPCFNRHLVTLSNSVFTFSYKKAQRDLGYEPLYTWEEAKQKTKEWIGSL
VKQHKETLKTKIH
|
| External Links |
|---|
| GenBank ID Protein
| CAA35615.1 |
| UniProtKB/Swiss-Prot ID
| P14893 |
| UniProtKB/Swiss-Prot Entry Name
| 3BHS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X17614 |
| GeneCard ID
| HSD3B |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
