| Identification |
|---|
| BMDB Protein ID
| BMDBP01049 |
| Secondary Accession Numbers
| None |
| Name
| A disintegrin and metalloproteinase with thrombospondin motifs 2 |
| Synonyms
|
Not Available
|
| Gene Name
| ADAMTS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Cleaves the propeptides of type I and II collagen prior to fibril assembly (PubMed:7622483). Does not act on type III collagen (PubMed:7622483). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| ADAMTS2 |
| Gene Sequence
|
>3618 bp
ATGGATCCGCCGGCGGGAGCCGCCGGCCGCCTGCTCTGCCCCGCGCTGTTGCTGCTCCTG
CTGCTGCCGCTGCCCGCGGACGCCCGGCTCGCCGCCGCTGCCGCCGACCCCCCAGGCGGG
CCCCAGGGGCACGGAGCCGAGCGCATCCTGGCGGTGCCGGTGCGCACTGACGCCCAGGGC
CGCTTGGTGTCCCACGTGGTGTCGGCGGCGACGGCCCCAGCTGGGGTGCGGACCCGCAGG
GCCGCCCCTGCCCAGATCCCGGGGCTCTCTGGAGGCAGCGAGGAGGACCCCGGTGGCCGC
CTCTTCTACAATGTTACGGTGTTTGGCCGAGACCTGCACCTGCGGCTGCGGCCCAACGCC
CGCCTCGTGGCGCCTGGGGCCACGGTGGAGTGGCAGGGAGAATCGGGTGCCACCCGCGTG
GAGCCCCTGCTTGGGACCTGCCTCTACGTCGGAGACGTCGCGGGCCTGGCTGAATCCTCT
TCCGTGGCGCTCAGCAACTGCGATGGGCTGGCTGGCCTGATCCGTATGGAAGAGGAGGAA
TTCTTTATTGAGCCCCTGGAGAAAGGTCTGGCGGCGAAGGAGGCCGAACAGGGCCGTGTA
CACGTGGTGTATCATCGACCGACCACCTCCAGACCCCCTCCTCTGGGGGGGCCACAGGCC
CTGGACACAGGGATCTCCGCAGACAGCCTGGACAGCCTCAGCCGTGCTCTGGGTGTTCTG
GAGGAGCGAGTCAACAGCTCCAGGCGGAGGATGCGCAGGCATGCTGCCGACGACGACTAC
AACATCGAGGTCCTGCTTGGGGTGGACGACTCTGTGGTCCAGTTCCACGGGACGGAGCAC
GTGCAGAAGTACCTGCTCACCCTCATGAACATTGTCAACGAAATCTATCACGATGAGTCC
TTGGGGGCCCACATCAATGTCGTCCTGGTGCGGATAATCCTGCTGAGCTACGGGAAGTCC
ATGAGTCTCATTGAGATTGGGAACCCCTCTCAAAGTCTGGAGAATGTTTGCCGCTGGGCC
TACCTCCAGCAGAAGCCAGACACTGATCACGACGAGTACCACGATCACGCCATATTCCTC
ACACGGCAGGACTTCGGGCCCTCGGGCATGCAAGGCTATGCTCCTGTCACTGGGATGTGC
CACCCCGTCCGCAGCTGCACGCTGAACCACGAGGACGGCTTCTCCTCTGCGTTCGTGGTG
GCCCACGAGACTGGCCATGTGCTGGGCATGGAGCATGATGGGCAGGGCAACCGCTGCGGT
GACGAGGTGCGGCTGGGCAGCATCATGGCGCCCCTGGTGCAGGCAGCCTTCCATCGCTTC
CACTGGTCCCGCTGCAGCCAGCAGGAGCTGAGCCGCTACCTGCACTCCTATGACTGCCTG
CGGGATGACCCCTTCACCCACGACTGGCCGGCGCTGCCCCAGCTCCCCGGGCTGCACTAC
TCCATGAACGAGCAGTGCCGTTTCGACTTTGGCCTTGGTTACATGATGTGTACCGCGTTC
CGGACCTTCGACCCGTGCAAACAGCTGTGGTGCAGCCACCCTGACAACCCCTACTTTTGC
AAGACAAAGAAGGGGCCACCCCTGGATGGGACCATGTGTGCGCCTGGCAAGCACTGCTTT
AAAGGACACTGCATCTGGCTGACACCTGACATTCTCAAACGAGATGGCAACTGGGGTGCC
TGGAGTCCCTTCGGCTCCTGCTCGCGTACCTGCGGCACAGGTGTGAAGTTCAGGACCCGT
CAGTGCGACAACCCACACCCAGCCAATGGGGGCCGCACATGCTCGGGCCTCGCCTACGAT
TTCCAGCTCTGCAACTCGCAGGACTGCCCTGACGCGCTGGCCGACTTCCGCGAGGAGCAG
TGCCGGCAGTGGGACCTGTACTTCGAGCATGGTGACGCTCAACACCACTGGCTGCCCCAC
GAGCACCGGGACGCCAAGGAGCGGTGTCATCTCTACTGTGAGTCCAAGGAGACCGGGGAG
GTGGTGTCCATGAAGCGTATGGTGCATGACGGGACACGCTGTTCCTACAAGGACGCCTTC
AGCCTCTGCGTGCGTGGGGACTGCAGGAAGGTGGGCTGTGACGGGGTGATCGGCTCCAGC
AAGCAGGAGGACAAGTGTGGTGTGTGCGGAGGGGACAACTCCCACTGCAAGGTGGTCAAG
GGCACGTTCTCGCGCTCGCCCAAGAAGCTTGGTTACATCAAGATGTTTGAGATCCCGGCA
GGAGCCAGACACCTGCTAATCCAGGAAGCAGACACCACCAGCCATCACCTGGCCGTCAAA
AACCTGGAGACAGGCAAGTTCATTTTAAATGAGGAGAATGACGTGGATCCCAACTCCAAG
ACCTTCATCGCCATGGGCGTGGAGTGGGAGTACCGGGATGAGGACGGCCGGGAGACGCTG
CAGACCATGGGCCCCCTCCACGGCACCATCACTGTGCTGGTCATCCCAGAGGGGGACGCC
CGCATCTCACTGACCTACAAGTACATGATCCATGAGGACTCGCTCAATGTGGATGACAAC
AACGTCCTGGAAGACGACTCTGTGGGCTATGAGTGGGCCCTGAAGAAGTGGTCGCCCTGC
TCCAAGCCCTGCGGTGGAGGGTCCCAATTCACCAAGTATGGCTGCCGCCGGAGGCTGGAC
CACAAGATGGTGCACCGAGGCTTCTGCGACTCCGTCTCAAAGCCCAAAGCCATCCGCCGG
ACCTGCAACCCACAGGAGTGCTCCCAGCCCGTGTGGGTCACGGGTGAGTGGGAGCCGTGC
AGCCGGAGCTGTGGGCGGACAGGCATGCAGGTTCGCTCTGTGCGCTGTGTTCAGCCTCTG
CACAACAACACCACCCGCTCCGTGCACACCAAGCACTGCAATGACGCTCGACCCGAGGGC
CGCCGGGCCTGCAACCGCGAGCTGTGCCCTGGCCGGTGGCGGGCTGGATCCTGGTCCCAG
TGCTCAGTAACCTGTGGAAACGGCACCCAGGAACGGCCAGTGCTCTGCCGAACTGCGGAC
GACAGTTTCGGGGTGTGCCGGGAGGAGCGGCCTGAGACGGCAAGGATCTGCAGGCTTGGC
CCCTGTCCCCGAAACACCTCTGACCCCTCCAAGAAGAGCTACGTGGTCCAGTGGCTATCC
CGACCGGACCCCAACTCGCCAGTCCAGGAGACCTCGTCAAAGGGCCGCTGCCAAGGTGAC
AAGTCAGTGTTCTGTAGGATGGAAGTCTTGTCTCGTTATTGCTCCATCCCAGGCTACAAT
AAGCTGTGCTGCAAGTCCTGTAACCCGCACGACAACCTCACTGATGTGGACGACAGGGCA
GAGCCACCCTCTGGGAAGCACAATGACATTGAAGAGCTCATGCCCACCCTTTCAGTGCCC
ACTCTAGTCATGGAGGTGCAGCCTCCGCCAGGCATACCCCTGGAGGTGCCTCTCAATACT
TCCAGCACCAATGCCACCGAGGACCATCCAGAAACCAATGCTGTGGATGTGCCCTACAAA
ATCCCTGGCCTGGAAGATGAAGTCCAGCCACCCAACCTGATCCCTCGACGACCGAGCCCA
TATGAAAAGACCAGAAACCAAAGAATCCAAGAGCTCATTGATGAGATGAGGAAGAAAGAG
ATGCTCGGAAAGTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1205 |
| Molecular Weight
| 133888.0 |
| Theoretical pI
| 6.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>A disintegrin and metalloproteinase with thrombospondin motifs 2
MDPPAGAAGRLLCPALLLLLLLPLPADARLAAAAADPPGGPQGHGAERILAVPVRTDAQG
RLVSHVVSAATAPAGVRTRRAAPAQIPGLSGGSEEDPGGRLFYNVTVFGRDLHLRLRPNA
RLVAPGATVEWQGESGATRVEPLLGTCLYVGDVAGLAESSSVALSNCDGLAGLIRMEEEE
FFIEPLEKGLAAKEAEQGRVHVVYHRPTTSRPPPLGGPQALDTGISADSLDSLSRALGVL
EERVNSSRRRMRRHAADDDYNIEVLLGVDDSVVQFHGTEHVQKYLLTLMNIVNEIYHDES
LGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTDHDEYHDHAIFL
TRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCG
DEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLRDDPFTHDWPALPQLPGLHY
SMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCF
KGHCIWLTPDILKRDGNWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYD
FQLCNSQDCPDALADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESKETGE
VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVK
GTFSRSPKKLGYIKMFEIPAGARHLLIQEADTTSHHLAVKNLETGKFILNEENDVDPNSK
TFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPEGDARISLTYKYMIHEDSLNVDDN
NVLEDDSVGYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCDSVSKPKAIRR
TCNPQECSQPVWVTGEWEPCSRSCGRTGMQVRSVRCVQPLHNNTTRSVHTKHCNDARPEG
RRACNRELCPGRWRAGSWSQCSVTCGNGTQERPVLCRTADDSFGVCREERPETARICRLG
PCPRNTSDPSKKSYVVQWLSRPDPNSPVQETSSKGRCQGDKSVFCRMEVLSRYCSIPGYN
KLCCKSCNPHDNLTDVDDRAEPPSGKHNDIEELMPTLSVPTLVMEVQPPPGIPLEVPLNT
SSTNATEDHPETNAVDVPYKIPGLEDEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKE
MLGKF
|
| External Links |
|---|
| GenBank ID Protein
| CAA65253.1 |
| UniProtKB/Swiss-Prot ID
| P79331 |
| UniProtKB/Swiss-Prot Entry Name
| ATS2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X96389 |
| GeneCard ID
| ADAMTS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
