| Identification |
|---|
| BMDB Protein ID
| BMDBP01057 |
| Secondary Accession Numbers
| |
| Name
| Betaine--homocysteine S-methyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| BHMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). |
| Pathways
|
- Amine and polyamine degradation
- Amino-acid biosynthesis
- Betaine degradation
- L-methionine biosynthesis via de novo pathway
- L-methionine from L-homocysteine (BhmT route): step 1/1
- Sarcosine from betaine: step 1/2.
|
| Reactions
|
| Betaine + Homocysteine → Dimethylglycine + L-Methionine |
details
|
| L-Cystathionine → Homocysteine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| BHMT |
| Gene Sequence
|
>1224 bp
ATGGCACCGGCTGGGGGCAAAAATGTCAAGAAGGGCATCCTAGAACGGCTAAACTCTGGA
GAGGTCATCATCGGAGACGGAGGGTTTGTCTTTGCGCTGGAGAAGAGGGGCTACGTGAAG
GCAGGGCCCTGGACCCCAGAAGCTGCTGTGGAACACCCAGAAGCAGTTCGCCAACTTCAT
CGAGAGTTCCTCAGAGCTGGCTCGAATGTCATGCAGACCTTCACCTTCTATGCCAGTGAA
GACAAGCTGGAGAACAGGGGGAACTATGTTGCAGAGAAAATATCCGGGCAGAAAGTCAAT
GAAGCCGCTTGTGACATTGCCCGGCAAGTGGCTGATGAAGGAGATGCTTTGGTAGCAGGG
GGTGTGAGCCAGACACCTTCGTACCTTAGCTGCAAGAGCGAAACTGAAGTCAAAAAAGTC
TTTCAGCAACAGTTAGAGGTCTTCGTAAAGAAGAACGTGGACTTCTTGATCGCAGAGTAT
TTTGAACATGTTGAAGAGGCTGTATGGGCAGTTGAAGCCTTGAAAGCATCAGGGAAACCA
GTGGCGGCAACTATGTGCATCGGCCCAGAGGGAGACTTGCACAGCGTGACCCCTGGCGAG
TGTGCAGTGCGCCTGGTTAAAGCAGGAGCTTCCATCGTGGGGGTAAACTGCCATTTTGAC
CCCACAATTAGCTTACAGACAGTGAAGCTCATGAAAGAAGGCTTGGAGGCTGCCGGACTG
AAAGCCCACCTCATGAGCCAGCCCTTGGCCTACCACACTCCTGACTGCGGCAAGCAGGGG
TTTATTGACCTGCCAGAATTCCCCTTTGGACTGGAACCCAGAGTTGCAACCAGATGGGAT
ATTCAAAAGTATGCCAGAGAGGCCTACAACCTGGGGGTCAGGTACATAGGTGGGTGCTGT
GGATTTGAACCCTACCACATCAGGGCAATTGCAGAGGAGCTGGCTCCGGAGAGGGGATTT
TTGCCACTGGCTTCAGAAAAACATGGCAGCTGGGGAAGTGGTTTGGATATGCACACCAAA
CCCTGGATTAGAGCCAGGGCCAGGAAGGAATACTGGGAGAATCTTCAGATAGCCTCGGGC
AGGCCGTACAACCCTTCCATGTCAAAGCCGGACGCCTGGGGAGTGACCAAAGGAACAGCC
GAGCTTATGCAGCAGAAGGAAGCCACAACGGAGCAGCAGCTGAGAGAGCTCTTCGAAAAA
CAGAAGTTCAAGTCTGCACAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 407 |
| Molecular Weight
| 44878.0 |
| Theoretical pI
| 6.84 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Betaine--homocysteine S-methyltransferase 1
MAPAGGKNVKKGILERLNSGEVIIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLH
REFLRAGSNVMQTFTFYASEDKLENRGNYVAEKISGQKVNEAACDIARQVADEGDALVAG
GVSQTPSYLSCKSETEVKKVFQQQLEVFVKKNVDFLIAEYFEHVEEAVWAVEALKASGKP
VAATMCIGPEGDLHSVTPGECAVRLVKAGASIVGVNCHFDPTISLQTVKLMKEGLEAAGL
KAHLMSQPLAYHTPDCGKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCC
GFEPYHIRAIAEELAPERGFLPLASEKHGSWGSGLDMHTKPWIRARARKEYWENLQIASG
RPYNPSMSKPDAWGVTKGTAELMQQKEATTEQQLRELFEKQKFKSAQ
|
| External Links |
|---|
| GenBank ID Protein
| AAW39034.1 |
| UniProtKB/Swiss-Prot ID
| Q5I597 |
| UniProtKB/Swiss-Prot Entry Name
| BHMT1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AY854632 |
| GeneCard ID
| BHMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
