| Identification |
|---|
| BMDB Protein ID
| BMDBP01059 |
| Secondary Accession Numbers
| None |
| Name
| Aprataxin |
| Synonyms
|
Not Available
|
| Gene Name
| APTX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| APTX |
| Gene Sequence
|
>1071 bp
ATGAGTAACGTGAGCTTGTCGGCCTCAGCCGTCTCGAGAGTAATGATGCGGGTGTGCTGG
TTGGTGAGACAGGACAACCGGCACCAGCGAATCAAACTTCCACATTTGGAAACAGTCATG
GTTGGGCGCAGCCCAGAGACCAAGATCGCCGACAAGAAGTGTTCTCGACAGCAAGTACAG
TTGAAAGCAGAGTGTAACAAAGGATATGTCAAGGTAAAGCAGGTAGGGGTCAATCCCACC
AGCATTGACTCAGTCATAATTGGGAAGGACCAGGAGGTGAAGCTGCAGCCTGGCCAGGTC
CTCTACCTGGTGAATGAACTTTATCCGTATATTATAGAGTTTGAGGAAGAGACAAAGAGC
CCTGGCCTGGAGTCACACAGGAAGAGAAAGAGGTCAGGCAGTAGCGATCCTACAGAAAGG
GGTGCTGACCCGGAAGCTGAGCCCAGCACAGGACTGGAACCTGGGAGCAACCCTCACCAG
TGCTCTGTGCCTCCAAAGAAGGAGAAGGATGCATCCATCAAAAAGGAATCCTTGGGCCAC
TGGAGTCAAGGCTTGAAGATTTCTATGGAGGACCCCAAAATGCAGGTTTACAAAGATGAG
CAGGTGGTGGTGATAAAGGATAAATACCCCAAGGCTCGTTTCCACTGGCTGGTCTTACCT
TGGGCCTCCATTTCCAGTCTGAAGGCTGTGACCAGAGAACATCTTGAGCTCCTCAGACAC
ATGCACGCTGTTGGAGAGAAAGTGATTGCTGACTTCGCTGGGTCCAGCAAATTCCGCTTC
CGATTGGGCTACCATGCCATTCCCAGCATGAGCCATGTACACCTCCATGTGATCAGCCAG
GATTTTGATTCTCCTTGCCTTAAAAACAAAAAACACTGGAATTCTTTCAATACTGAGTAC
TTCCTTGAATCACAAGCTGTGATTGAGATGGTGCAAGAGGCTGGCAGGGTGACCGTCCGA
GACGGGATGCCCGAGCTCCTGAAGCTGCCCCTCCGTTGTCACGAGTGCCAGCAGCTGCTG
CCTTCCATCCCTCAGCTGAAGGAGCACCTCAGGAAGCACTGGTCCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 356 |
| Molecular Weight
| 40659.0 |
| Theoretical pI
| 9.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aprataxin
MSNVSLSASAVSRVMMRVCWLVRQDNRHQRIKLPHLETVMVGRSPETKIADKKCSRQQVQ
LKAECNKGYVKVKQVGVNPTSIDSVIIGKDQEVKLQPGQVLYLVNELYPYIIEFEEETKS
PGLESHRKRKRSGSSDPTERGADPEAEPSTGLEPGSNPHQCSVPPKKEKDASIKKESLGH
WSQGLKISMEDPKMQVYKDEQVVVIKDKYPKARFHWLVLPWASISSLKAVTREHLELLRH
MHAVGEKVIADFAGSSKFRFRLGYHAIPSMSHVHLHVISQDFDSPCLKNKKHWNSFNTEY
FLESQAVIEMVQEAGRVTVRDGMPELLKLPLRCHECQQLLPSIPQLKEHLRKHWSK
|
| External Links |
|---|
| GenBank ID Protein
| AAK91769.1 |
| UniProtKB/Swiss-Prot ID
| Q7YRZ2 |
| UniProtKB/Swiss-Prot Entry Name
| APTX_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY040778 |
| GeneCard ID
| APTX |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
