| Identification |
|---|
| BMDB Protein ID
| BMDBP01075 |
| Secondary Accession Numbers
| |
| Name
| Thiamin pyrophosphokinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| TPK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity). |
| Pathways
|
- Cofactor biosynthesis
- Thiamine diphosphate biosynthesis
- Thiamine diphosphate from thiamine: step 1/1
|
| Reactions
|
| Adenosine triphosphate + Thiamine → Adenosine monophosphate + Thiamine pyrophosphate |
details
|
| Adenosine triphosphate + Thiamine pyrophosphate → ADP + Thiamin triphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| TPK1 |
| Gene Sequence
|
>732 bp
ATGGAGCATGCCATTACCCCGCTGGACCCCCTGCTTCCCTCTGGGAGTTTGAAATACTGC
CTTGTGATTCTGAACCAGCCTTTGGACAAATGTTTTCGTCATCTTTGGCACAAAGCTCTT
TTAAGAGCCTGTGCTGATGGAGGTGCCAACCACTTATATGACGTCACAGAAGGAGAGAGG
GAGAGCTTTCTGCCTGAATTCATCAGTGGAGACTTTGATTCTATTAGGCCTGAAGTTAGA
GAACACTACGCTATTAAGGGCTGTGAAATTATTTCAACTCCTGATCAAGACCATACTGAT
TTTACCAAGTGCCTTGAAGTGCTCCAAAAGAAGATAGAAGAAAAAGACCTACAGGTAGAT
ATGATCGTGACCTTGGGAGGACTTGCTGGACGCTTTGACCAGATCATGGCATCTGTGAGC
ACTTTGTTCCAAGCGCCTCAAATAACTTCTTTGCCAGTTATAATAATCCAAGAGGAATCT
CTCATCTACCTGCTCCAACCGGGAAAGCACAAATTGCATGTAGATACCGGGATGGAAGGT
GATTGGTGTGGCCTCATTCCTGTTGGACAGCCTTGCAATCAGGTGACCACAACAGGCCTA
AAGTGGAACCTTACACATCAGATGCTTGGCTTTGGAACACTAGTCAGCACGTCCAACACC
TACGACGGATCTGGTGTTGTGACTGTAGAGACGGACCATCCCCTGCTCTGGACCATGGCC
ATAAAAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 243 |
| Molecular Weight
| 27028.0 |
| Theoretical pI
| 4.94 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Thiamin pyrophosphokinase 1
MEHAITPLDPLLPSGSLKYCLVILNQPLDKCFRHLWHKALLRACADGGANHLYDVTEGER
ESFLPEFISGDFDSIRPEVREHYAIKGCEIISTPDQDHTDFTKCLEVLQKKIEEKDLQVD
MIVTLGGLAGRFDQIMASVSTLFQAPQITSLPVIIIQEESLIYLLQPGKHKLHVDTGMEG
DWCGLIPVGQPCNQVTTTGLKWNLTHQMLGFGTLVSTSNTYDGSGVVTVETDHPLLWTMA
IKN
|
| External Links |
|---|
| GenBank ID Protein
| AAX08853.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9T4 |
| UniProtKB/Swiss-Prot Entry Name
| TPK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT020836 |
| GeneCard ID
| TPK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
