| Identification |
|---|
| BMDB Protein ID
| BMDBP01125 |
| Secondary Accession Numbers
| None |
| Name
| Retinal guanylyl cyclase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| GUCY2D |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:8102054). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| GUCY2D |
| Gene Sequence
|
>3333 bp
ATGACCGCCTGCACCTTCCTCGCGGGTGGGCTTCGGGACCCCGGACTCTGCGGACCCACG
CGGTGGGCTCCGTCTCCGCCCGGCCTTCCCCCGATCCCGCCCCGGCCCCGGCTTCGGCTG
AGGCCACCGCTGCTGCTGCTGTTGCTCCTGCCGCGCTCCGTCCTCTCGGCCGTGTTCACT
GTGGGGGTGCTGGGTCCCTGGGCCTGCGACCCCATCTTCGCGCGTGCCCGCCCGGACCTG
GCCGCCCGCCTGGCCGCCTCCCGCCTGAACCACGCGGCTGCCCTGGAGGGCGGCCCCCGC
TTCGAGGTCGCGCTGCTGCCCGAGCCGTGCCGGACGCCGGGCTCGCTGGGGGCCGTGTCC
TCGGCGCTCACCCGCGTCTCGGGTCTAGTTGGGCCGGTGAACCCCGCAGCTTGCCGGCCG
GCGGAATTACTAGCCCAGGAGGCGGGGGTCGCTCTGGTCCCCTGGGGCTGTCCCGGGACG
CGGGCAGCGGGCACCACGGCTCCGGTGGTGACGCCCGCGGCCGATGCCCTCTACGCCCTC
CTGCGCGCTTTCCGCTGGGCGCACGTGGCCTTGGTCACCGCCCCCCAGGACCTGTGGGTG
GAGGCGGGACACGCACTTTCCACGGCGCTCAGGGCCAGGGGCCTGCCCGTGGCCCTGGTG
ACCTCCATGGAGCCCTCCGACCTGTCTGGAGCCCGGGAGGCCTTGAGGAGGGTCCAAGAT
GGGCCCAGAGTCAGAGCAGTGATCATGGTAATGCACTCGGTCTTGCTGGGCGGCGAGGAG
CAGCGCTGCCTGCTGGAGGCTGCAGAGGAACTGGGCCTGGCCGACGGTTCCCTGGTCTTC
CTGCCCTTCGACACTCTCCACTACGCCTTGTCTCCAGGCCCTGACGCCCTGGCGGTGCTC
GCCAACAGCTCACAGCTTCGCAAGGCCCACGATGCAGTGCTCACCCTCACCCGTCACTGT
CCCCTGGGAGGCAGCGTGCGGGACAGCCTGCGCAGGGCCCAAGAGCACCGGGAGCTGCCC
CTGGACCTCAATCTGCAGCAGGTATCCCCTCTCTTCGGCACCATCTATGACTCAGTCTTC
TTGTTGGCTGGGGGCGTGGCGCGAGCACGGGTGGCCGCAGGTGGCGGCTGGGTGTCCGGA
GCAGCGGTGGCCCGCCATATCCGGGATGCCCGGGTCCCTGGCTTCTGTGGGGCCCTGGGA
GGAGCTGAGGAGCCCTCGTTTGTGCTACTGGACACGGATGCCACTGGGGACCAGCTGTTC
GCTACATACGTTCTGGACCCTACGCAGGGCTTCTTCCACTCCGCTGGAACCCCAGTGCAT
TTTCCTAAAGGTGGACGGGGGCCTGGGCCTGACCCCTCGTGTTGGTTCGACCCAGACACC
ATCTGCAACGGAGGAGTGGAACCCAGCGTCGTCTTTATTGGCTTCCTCCTGGTGGTTGGG
ATGGGGCTGGCTGGGGCCTTCCTGGCCCATTATTGTAGGCACCGGCTGCTTCACATCCAA
ATGGTCTCTGGCCCCAACAAGATCATCCTGACTCTGGATGACATCACCTTCCTCCACCCG
CATGGGGGCAACTCTCGAAAGGTGGCCCAGGGGAGTCGAACCAGTCTGGCTGCCCGCAGC
ATATCAGATGTTCGCAGCATCCACAGCCAGCTCCCGGATTACACCAACATTGGCCTCTAT
GAGGGAGACTGGGTTTGGCTGAAGAAATTCCCAGGAGATCGGCATATAGCTATCCGCCCA
GCAACCAAGATGGCCTTCTCCAAGATCCGGGAACTCCGGCATGAAAACGTGGCCCTCTAC
CTGGGCCTCTTCCTGGCGGGAGGAGCTGGCGGCCCCGCGGCCCCCGGGGAAGGCGTGCTG
GCTGTGGTCTCGGAGCACTGCGCCCGCGGCTCCCTCCAAGACCTCCTCGCCCAGAGAGAC
ATAAAGCTGGACTGGATGTTCAAGTCTTCCCTCCTCCTGGACCTCATCAAGGGAATAAGG
TATCTGCACCATCGAGGGGTGGCCCATGGGCGGCTGAAGTCACGGAACTGCGTGGTGGAC
GGGAGGTTCGTGCTTAAAGTCACCGACCACGGTCATGGGCGACTGCTGGAGGCGCAGAGG
GTGTTACCTGAGCCACCGAGCGCGGAGGACCAGCTATGGACAGCCCCGGAGCTGCTTCGA
GACCCGGTCCTGGAGCGCCGGGGAACGCTGGCCGGCGACGTCTTCAGTCTGGGCATCATT
ATGCAGGAGGTCGTGTGCCGCAGCGCCCCCTACGCCATGCTGGAGCTCACTCCCGAGGAA
GTGGTGAAGAGGGTACAGAGCCCCCCTCCACTGTGTCGGCCCTCCGTGTCCATAGACCAG
GCGCCCATGGAGTGCATCCAGCTGATGAAACAGTGCTGGGCAGAGCAGCCAGAACTTCGG
CCCTCCATGGATCGCACCTTTGAACTGTTCAAGAGCATCAACAAGGGCCGGAAGATGAAC
ATCATCGACTCTATGCTGCGGATGCTGGAACAGTACTCCAGTAACCTGGAGGACCTGATC
CGGGAGCGCACAGAGGAGCTGGAGCTGGAAAAGCAGAAGACAGACCGGCTGCTCACACAG
ATGCTGCCTCCGTCTGTGGCAGAGGCGCTGAAGATGGGGACACCTGTGGAGCCCGAGTAT
TTCGAAGAGGTGACACTGTACTTCAGTGACATTGTGGGTTTCACCACCATCTCAGCCATG
AGTGAGCCCATCGAAGTGGTAGACCTGCTCAACGACCTCTACACACTCTTTGATGCCATC
ATCGGTTCCCATGATGTCTACAAGGTGGAGACAATTGGGGATGCCTACATGGTGGCCTCC
GGGCTGCCCCAGAGGAACGGGCACCGGCACGCGGCAGAGATCGCCAATATGGCTCTGGAC
ATCCTCAGCGCCGTGGGCACCTTCCGCATGCGCCACATGCCGGAAGTGCCCGTGCGCATC
CGCATTGGCCTGCACTCGGGCCCGTGCGTGGCGGGCGTGGTGGGCCTCACCATGCCCCGG
TACTGCCTGTTTGGGGACACAGTCAACACCGCTTCGGCCATGGAGTCCACCGGGCTGCCT
TACCGCATCCACGTGAACAGGAGCACCGTGCAGATCCTTTCCGCCCTAAACGAGGGCTTC
CTGACTGAGGTGCGGGGCCGCACGGAGCTGAAGGGCAAGGGCGCAGAGGAAACCTACTGG
CTGGTGGGCAGACGCGGCTTCAACAAACCCATCCCCAAACCACCGGACCTGCAACCCGGG
GCCAGCAACCACGGCATCAGCCTGCACGAGATCCCCCCTGATCGGCGCCAGAAGCTAGAG
AAGGCGAGGCCAGGCCAGTTTTCTGGGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1110 |
| Molecular Weight
| 120369.0 |
| Theoretical pI
| 7.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Retinal guanylyl cyclase 1
MTACTFLAGGLRDPGLCGPTRWAPSPPGLPPIPPRPRLRLRPPLLLLLLLPRSVLSAVFT
VGVLGPWACDPIFARARPDLAARLAASRLNHAAALEGGPRFEVALLPEPCRTPGSLGAVS
SALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPVVTPAADALYAL
LRAFRWAHVALVTAPQDLWVEAGHALSTALRARGLPVALVTSMEPSDLSGAREALRRVQD
GPRVRAVIMVMHSVLLGGEEQRCLLEAAEELGLADGSLVFLPFDTLHYALSPGPDALAVL
ANSSQLRKAHDAVLTLTRHCPLGGSVRDSLRRAQEHRELPLDLNLQQVSPLFGTIYDSVF
LLAGGVARARVAAGGGWVSGAAVARHIRDARVPGFCGALGGAEEPSFVLLDTDATGDQLF
ATYVLDPTQGFFHSAGTPVHFPKGGRGPGPDPSCWFDPDTICNGGVEPSVVFIGFLLVVG
MGLAGAFLAHYCRHRLLHIQMVSGPNKIILTLDDITFLHPHGGNSRKVAQGSRTSLAARS
ISDVRSIHSQLPDYTNIGLYEGDWVWLKKFPGDRHIAIRPATKMAFSKIRELRHENVALY
LGLFLAGGAGGPAAPGEGVLAVVSEHCARGSLQDLLAQRDIKLDWMFKSSLLLDLIKGIR
YLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLR
DPVLERRGTLAGDVFSLGIIMQEVVCRSAPYAMLELTPEEVVKRVQSPPPLCRPSVSIDQ
APMECIQLMKQCWAEQPELRPSMDRTFELFKSINKGRKMNIIDSMLRMLEQYSSNLEDLI
RERTEELELEKQKTDRLLTQMLPPSVAEALKMGTPVEPEYFEEVTLYFSDIVGFTTISAM
SEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGHRHAAEIANMALD
ILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASAMESTGLP
YRIHVNRSTVQILSALNEGFLTEVRGRTELKGKGAEETYWLVGRRGFNKPIPKPPDLQPG
ASNHGISLHEIPPDRRQKLEKARPGQFSGK
|
| External Links |
|---|
| GenBank ID Protein
| AAA50790.1 |
| UniProtKB/Swiss-Prot ID
| P55203 |
| UniProtKB/Swiss-Prot Entry Name
| GUC2D_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L37089 |
| GeneCard ID
| GUCY2D |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
