| Identification |
|---|
| BMDB Protein ID
| BMDBP01135 |
| Secondary Accession Numbers
| None |
| Name
| Histidine--tRNA ligase, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| HARS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. |
| Pathways
|
- Histidine Metabolism
- Protein Synthesis: Histidine
|
| Reactions
|
| Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His) |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| HARS1 |
| Gene Sequence
|
>1530 bp
ATGGCTGATCGTGCGGCGCTGGAGGATCTGGTGCGAGTTCAGGGAGAGCGTGTGCGGGGC
CTTAAGCAGCAGAAGGCCAGCGCGGAGCAGATCGAGGAGGAGGTGGCAAAACTACTGAAA
CTGAAGGCACAGCTGGGCCCTGATGAAGGAAAACCGAAGTTTGTGCTCAAAACCCCCAAG
GGCACAAGAGATTATAGTCCCCGGCAGATGGCAGTTCGAGAGAAGGTGTTTGATGTAATC
ATCAGCTGCTTCAAGCGCCATGGTGCAGAAGTGATTGATACACCTGTATTTGAACTAAAG
GAAACACTGACTGGAAAGTATGGAGAAGACTCTAAGCTTATCTATGACTTGAAGGACCAG
GGTGGGGAGCTGCTCTCTCTTCGATATGACCTCACTGTTCCTTTTGCTCGATACTTGGCA
ATGAATAAACTGACCAACATTAAACGCTACCACATAGCAAAAGTATATCGGCGGGATAAC
CCAGCCATGACCCGAGGCCGATATCGGGAATTCTACCAATGTGATTTTGACATTGCTGGG
CAGTTTGACCCCATGCTTCCTGATGCAGAGTGCCTGAAGATCATGTGTGAGATCCTGAGT
TCACTCCAGATTGGCGACTTCCTGGTCAAGGTGAATGATCGGCGCATCTTAGATGGGATG
TTTGCCATCTGTGGTGTTCCAGATAGCAAGTTCCGCACCATCTGCTCCTCTGTGGACAAG
CTGGACAAGGTGTCCTGGGAGGAAGTAAAGAATGAGATGGTAGGAGAGAAGGGCCTGGCA
CCTGAGGTGGCTGACCGCATTGGGGACTACGTCCAGCAACACGGTGGAGTATCCCTGGTG
GAACAGCTGCTCCAGGATCCTAAACTGTCCCAGAACAAGCAGGCCCTCGAGGGCCTGGGA
GACCTGAAGCTGCTATTTGAGTATCTGACCTTGTTTGGCATTGCTGACAAGATCTCCTTC
GACCTGAGCCTTGCTCGAGGACTGGACTACTATACCGGCGTGATCTATGAGGCAGTGCTG
CTACAGCCTCCAGCCCGAGCAGGGGAAGAACCCCTGGGTGTGGGCAGCGTGGCTGCTGGA
GGGCGCTATGATGGGCTGGTGGGCATGTTTGATCCCAAAGGGCGCAAGGTGCCCTGTGTA
GGGCTCAGCATTGGAGTAGAGCGGATCTTTTCCATCGTGGAGCAGAGGCTGGAGGCCTTG
GAGGAGAAGGTACGGACCACAGAGACACAGGTGCTTGTGGCATCTGCACAGAAGAAGCTG
CTGGAAGAGAGACTGAAGCTCATCTCAGAGTTATGGGATGCTGGGATCAAGGCAGAACTG
CTCTACAAAAAGAACCCCAAGTTACTGAATCAGCTGCAGTACTGTGAGGAGACAGGCATC
CCACTGGTGGCCATCATTGGTGAGCAAGAGCTCAAGGATGGGGTCATCAAGCTGCGCTCA
GTGGCCAGCAGGGAAGAGGTGGACGTCCGAAGAGAAGACCTTGTGGAGGAAATCAAAAGG
AGAACAAGCCAGCCGCTTTGCATCTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 509 |
| Molecular Weight
| 57285.0 |
| Theoretical pI
| 5.75 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histidyl-tRNA synthetase, cytoplasmic
MADRAALEDLVRVQGERVRGLKQQKASAEQIEEEVAKLLKLKAQLGPDEGKPKFVLKTPK
GTRDYSPRQMAVREKVFDVIISCFKRHGAEVIDTPVFELKETLTGKYGEDSKLIYDLKDQ
GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG
QFDPMLPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVPDSKFRTICSSVDK
LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG
DLKLLFEYLTLFGIADKISFDLSLARGLDYYTGVIYEAVLLQPPARAGEEPLGVGSVAAG
GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKVRTTETQVLVASAQKKL
LEERLKLISELWDAGIKAELLYKKNPKLLNQLQYCEETGIPLVAIIGEQELKDGVIKLRS
VASREEVDVRREDLVEEIKRRTSQPLCIC
|
| External Links |
|---|
| GenBank ID Protein
| AAI12732.1 |
| UniProtKB/Swiss-Prot ID
| Q2KI84 |
| UniProtKB/Swiss-Prot Entry Name
| HARS1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112731 |
| GeneCard ID
| HARS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
