| Identification |
|---|
| BMDB Protein ID
| BMDBP01148 |
| Secondary Accession Numbers
| None |
| Name
| Adenylate kinase 4, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| AK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| AK4 |
| Gene Sequence
|
>672 bp
ATGGCTTCCAAACTCCTGCGTGCGGTCATCCTTGGGCCGCCGGGCTCGGGCAAGGGCACC
GTGTGCCAGAGGATAGCCCAGAACTTTGGCCTTCAGCATCTCTCCAGCGGCCACTTCTTG
CGGGAGAACATCAAGGCCAACACGGAAGTTGGTGATATGGCAAAGCAATACATAGAGAAA
GGCCTTTTGGTTCCCGATCATGTGATCACACGCCTCATGCTGTTGGAGTTGGAGAACAGG
CGCGGCGAGCACTGGCTACTTGACGGTTTTCCTCGAACATTAGTTCAGGCTGAAGCCTTG
GACAGACTATGTGACCTGGATCTAGTGATCACTTTGAACATTCCATTCGAAACGCTCAAA
GATCGTCTCAGCCGACGTTGGATTCATCCTCCCAGTGGAAGGGTATATAACCTGGACTTC
AACCCACCTCATGTACATGGCATGGATGACGTCACTGGTGAGCCACTGGTCCAGCAGGAG
GATGACAAACCTGAAGCAGTTGCTGCCAGACTAAGGCAGTACAAGGATGTGGCAAAACCC
GTCATCGAGTTGTACAAGAGCCGAGGAGTGCTCCACCAGTTTTCAGGAACCGAGACTAAC
AAAATCTGGCCCTATGTTTACACGCTTTTCTCGAACAAGATCACACCTGTTCAGTCCAAA
GAAGCCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 25348.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenylate kinase isoenzyme 4, mitochondrial
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKANTEVGDMAKQYIEK
GLLVPDHVITRLMLLELENRRGEHWLLDGFPRTLVQAEALDRLCDLDLVITLNIPFETLK
DRLSRRWIHPPSGRVYNLDFNPPHVHGMDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKP
VIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPVQSKEAY
|
| External Links |
|---|
| GenBank ID Protein
| AAI20078.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCP1 |
| UniProtKB/Swiss-Prot Entry Name
| KAD4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120077 |
| GeneCard ID
| AK4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
