| Identification |
|---|
| BMDB Protein ID
| BMDBP01171 |
| Secondary Accession Numbers
| None |
| Name
| Cyclin-dependent kinase 4 |
| Synonyms
|
Not Available
|
| Gene Name
| CDK4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| CDK4 |
| Gene Sequence
|
>912 bp
ATGGCTACCTCCCGATATGAGCCAGTGGCTGAGATTGGTGTCGGTGCCTATGGGACAGTG
TACAAGGCCCGTGATCCCCACAGTGGCCACTTTGTGGCCCTCAAGAGTGTAAGAGTCCCC
AATGGAGGAGGTGCTGGAGGGGGCCTGCCCATCAGCACCGTTCGGGAGGTGGCCTTACTG
CGGCGTCTGGAGGCTTTTGAGCATCCCAATGTTGTCAGGCTTATGGACGTCTGTGCAACA
GCCCGAACTGACCGGGAGACCAAAGTGACCCTGGTGTTTGAGCATGTGGACCAAGATCTC
AGGACATATCTGGACAAGGCACCCCCACCAGGCTTGCCAGTGGAGACCATAAAAGATCTG
ATGCGCCAATTTCTAAGAGGCCTGGATTTCCTTCATGCCAACTGCATCGTTCACCGAGAC
CTGAAGCCAGAGAACATTCTGGTGACAAGTGGTGGGACAGTCAAGCTGGCTGACTTTGGC
CTGGCCAGAATCTACAGCTACCAGATGGCACTTACACCTGTGGTTGTTACACTCTGGTAT
CGTGCTCCAGAAGTTCTTTTGCAGTCTACGTATGCAACACCCGTGGACATGTGGAGCGTT
GGCTGTATCTTTGCAGAGATGTTTCGTCGAAAGCCTCTCTTCTGTGGAAACTCTGAAGCT
GACCAGTTAGGCAAAATCTTTGACCTGATTGGACTGCCCCCAGAGGATGACTGGCCCCGA
GATGTCTCTCTACCCCGAGGAGCCTTTTCCCCCCGAGGGCCCCGCCCAGTGCAGTCGGTG
GTCCCTGAGCTGGAGGAATCTGGAGCACAGCTGCTGCTGGAGATGCTGACTTTTAACCCA
CACAAGCGAATCTCTGCCTTCCGAGCCCTGCAGCACTCTTATCTACACAAGGCAGAAGGT
GACGCAGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 303 |
| Molecular Weight
| 33647.0 |
| Theoretical pI
| 7.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cell division protein kinase 4
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATARTDRETKVTLVFEHVDQDLRTYLDKAPPPGLPVETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFSPRGPRPVQSVVPELEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKAEG
DAE
|
| External Links |
|---|
| GenBank ID Protein
| AAI09859.1 |
| UniProtKB/Swiss-Prot ID
| Q32KY4 |
| UniProtKB/Swiss-Prot Entry Name
| CDK4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109858 |
| GeneCard ID
| CDK4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
