<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:25:46 UTC</creation_date>
  <update_date>2020-05-20 21:10:43 UTC</update_date>
  <accession>BMDBP01173</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>MVK</gene_name>
  <general_function>Lipid transport and metabolism</general_function>
  <specific_function>Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.</specific_function>
  <pathways>
    <pathway>
      <name>Isopentenyl diphosphate biosynthesis via mevalonate pathway</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Isopentenyl diphosphate from (R)-mevalonate: step 1/3</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Isoprenoid biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Steroid Biosynthesis</name>
      <smpdb_id>SMP0087233</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001341</accession>
      <name>ADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000227</accession>
      <name>Mevalonic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000538</accession>
      <name>Adenosine triphosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001343</accession>
      <name>Mevalonic acid-5P</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>17</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1191 bp
ATGTTGTCAGAAGTCCTGCTGGTGTCCGCTCCAGGGAAAGTCATTCTGCATGGAGAGCAT
GCCGTGGTCCATGGCAAGGTAGCACTAGCAGTGGCCTTGAACTTGAGAACATTTCTCCGG
CTTCAGCCCCACAGCAATGGGAGAGTGGGCCTCAACTTACCAAACATTGGCGTCAGGAGG
GCCTGGGACGTGGCCAGCCTTCAGCTGCTGGACACCAGCTTTCTGGGGCACGGTGACAGC
GCAGCGCTCACCGCGAAGCACGTGGAGAAGCTGAAGGAGGTGGCGGGCTTCCCCAAGGAC
TGTGTGGATCCTGAGCACCTGGCCGTGCTGGCCTTCCTCTACTTGTACCTGTCTATCTGC
CAGAGTCAGAGAGCCCTGCCCAGCCTGGACATCACTGTATGGTCGGAGCTGCCCACTGGG
GCCGGGCTGGGCTCCAGTGCCGCCTACTCCGTGTGTTTGGCAGCTGCCCTCCTGACCGCG
TGCGAGGAGATCCCAAACCCGCTGAAGGATGGGGAGGCTGCCGGCAGGTGGACCGAGGAG
AACTTGGAGTTAATTAACAAGTGGGCCTTCCAGGGGGAGAGGGTGATTCACGGGAACCCG
TCCGGAGTGGACAACGCCGTCAGCACCTGGGGAGGAGCACTCCGATACCAGCAAGGGAAG
ATTTCATCTTTAAAGAGGCCACCGGTTCTGAAGATCCTGCTGATCAACACCAAAGTGCCT
CGCAGCACCAAGGTCCTGGTGGCCAATGTCAGGAGCCGGCTACTGAAGTTCCCTGAGATC
GTGGCCCCTCTCCTGACCTCCATAGACGCCATCTCCCTGGAGTGCGAGCGGGTGCTGGGG
GAGATGGCGGCGGCCCCCACTCCAGAGCACTACCTCACGCTGGAGGAGCTCATCGACATG
AACCAGCACCATCTGAATGCCCTCGGTGTGGGCCATGCCTCGCTGGACCAGCTGTGCCAG
GTGACCACAGCCCACGGACTGCACAGCAAGCTCACTGGCGCGGGCGGCGGGGGCTGTGGC
ATCACGCTCCTCAGGCCAGATGTGGAGCGGCCGGCGGTAGAGGCCACGAAGCGGGCGCTG
AGCGGCTGTGGCTTTGACTGCTGGGAAACCAGCGTTGGTGCCCCCGGTGTCTCTGTCCAC
ACGGCCGCCTCCCTGGATGCCTCTGTCCAGCAAGGCCTGGACAGCCTCTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>396</residue_number>
    <molecular_weight>42070.0</molecular_weight>
    <theoretical_pi>6.79</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>468-492</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Mevalonate kinase
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLRLQPHSNGRVGLNLPNIGVRR
AWDVASLQLLDTSFLGHGDSAALTAKHVEKLKEVAGFPKDCVDPEHLAVLAFLYLYLSIC
QSQRALPSLDITVWSELPTGAGLGSSAAYSVCLAAALLTACEEIPNPLKDGEAAGRWTEE
NLELINKWAFQGERVIHGNPSGVDNAVSTWGGALRYQQGKISSLKRPPVLKILLINTKVP
RSTKVLVANVRSRLLKFPEIVAPLLTSIDAISLECERVLGEMAAAPTPEHYLTLEELIDM
NQHHLNALGVGHASLDQLCQVTTAHGLHSKLTGAGGGGCGITLLRPDVERPAVEATKRAL
SGCGFDCWETSVGAPGVSVHTAASLDASVQQGLDSL</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAX08849.1</genbank_protein_id>
  <uniprot_id>Q5E9T8</uniprot_id>
  <uniprot_name>KIME_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BT020832</genbank_gene_id>
  <genecard_id>MVK</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
