| Identification |
|---|
| BMDB Protein ID
| BMDBP01176 |
| Secondary Accession Numbers
| None |
| Name
| Mast/stem cell growth factor receptor Kit |
| Synonyms
|
Not Available
|
| Gene Name
| KIT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity). |
| Pathways
|
- Rac 1 cell motility signaling pathway
- Rac 1 Cell Motility Signaling Pathway
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| KIT |
| Gene Sequence
|
>2934 bp
ATGAGAGGCGCTCGCGGCGCCTGGGATTTCCTCTTCGTTCTGCTGCTCCTGCTCCTCGTC
CAGACAGGCTCTTCTCAGCCATCTGTGAGTCCAGGGGAACTGTCTCTACCATCTATCCAC
CCAGCAAAATCAGAGTTAATTGTCAGCGTTGGCGACGAGATTAGGCTGTTATGCACCGAT
CCAGGATTTGTCAAGTGGACTTTTGAGATCCTGGGTCAACTGAGTGAGAAAACAAACCCG
GAATGGATCACCGAGAAAGCAGAGGCCACAAATACAGGCAATTACACGTGCACCAATAAA
GGCGGCTTGAGCAGTTCCATTTATGTGTTTGTTAGAGACCCCGAGAAGCTTTTCCTGATT
GACCTTCCCTTGTACGGGAAAGAAGAAAACGACACGCTGGTTCGCTGTCCCCTGACAGAC
CCCGAGGTGACCAATTACTCTCTTACGGGGTGTGAGGGGAAACCTCTCCCCAAGGATTTG
ACATTTGTGGCCGACCCCAAGGCAGGTATCACAATCAGAAATGTGAAGCGCGAGTACCAT
CGGCTCTGTCTGCACTGCTCAGCGAATCAGAGGGGCAAGTCCATGCTGTCGAAGAAATTC
ACTCTGAAAGTGCGGGCAGCCATCAAAGCTGTGCCAGTTGTGTCTGTGTCCAAAACCAGC
TATCTTCTCAGGGAAGGAGAGGAATTTGCAGTGACATGCTTGATTAAAGACGTGTCTAGT
TCCGTGGACTCTATGTGGATAAAGGAAAACAGCCAGCAGACTAAAGCACAGACGAAGAAG
AATAGCTGGCATCAGGGTGACTTCAGTTATCTCCGTCAGGAAAGGTTGACTATCAGCTCA
GCAAGAGTGAATGATTCCGGTGTGTTCATGTGTTACGCCAATAACACTTTTGGATCAGCA
AATGTCACAACAACCTTAGAAGTAGTAGATAAAGGATTCATTAATATCTTCCCTATGATG
AACACAACAGTATTTGTAAATGATGGAGAGAATGTGGATCTGGTTGTTGAATATGAGGCA
TATCCCAAACCTGTACACCGACAATGGATATATATGAACAGAACCTCCACTGATAAGTGG
GACGATTATCCTAAGTCTGAAAATGAAAGTAATATCAGATACGTAAATGAACTTCATCTA
ACCAGATTAAAAGGGACTGAAGGAGGCACTTACACATTTCACGTGTCCAATTCTGATGTC
AATTCTTCCGTGACATTTAATGTTTACGTGAACACAAAACCAGAAATCCTGACGCATGAC
AGGCTGGTGAATGGCATGCTACAGTGCGTGGCCGCAGGGTTCCCGGAGCCAACCATCGAT
TGGTACTTTTGTCCAGGAACTGAGCAGAGGTGTTCTGTTCCCGTTGGGCCAGTGGATGTA
CAGATCCAAAACTCATCTGTCTCACCATTTGGAAAACTAGTGGTTTATAGCACCATTGAT
GACAGCACATTCAAACACAATGGGACGGTGGAGTGCAGGGCTTATAACGATGTGGGCAAG
AGTTCTGCCTCTTTTAACTTTGCATTTAAAGGTAACAGCAAAGAACAAATCCATGCTCAC
ACCCTGTTCACGCCGTTGCTGATTGGTTTTGTGATCGCAGCTGGTTTAATGTGTATCTTC
GTGATGATTCTTACATACAAATATTTGCAGAAACCCATGTATGAAGTACAGTGGAAAGTT
GTCGAGGAGATAAATGGAAACAATTATGTTTACATAGACCCAACACAACTTCCTTATGAT
CACAAATGGGAGTTTCCCAGGAACAGGCTGAGTTTTGGGAAAACCCTGGGTGCTGGCGCC
TTCGGGAAAGTTGTTGAGGCCACCGCTTATGGCTTAATTAAATCAGATGCAGCCATGACT
GTTGCTGTCAAGATGCTCAAACCAAGCGCCCATTTAACCGAACGAGAAGCCCTAATGTCT
GAACTCAAAGTCTTGAGTTACCTCGGTAATCATATGAATATTGTGAATCTTCTGGGAGCG
TGCACCATTGGAGGGCCCACCCTGGTCATTACAGAATATTGTTGCTATGGTGATCTTCTG
AATTTTTTGAGAAGAAAACGTGATTCATTTATTTGCTCAAAGCAGGAAGATCACGCCGAA
GTGGCGCTTTATAAGAACCTTCTTCATTCAAAGGAGTCTTCCTGCAATGATAGTACTAAT
GAGTACATGGACATGAAACCTGGAGTTTCTTATGTTGTACCAACCAAGGCAGACAAGAGG
AGATCTGCAAGAATAGGTTCATACATAGAAAGAGACGTGACTCCTGCTATCATGGAAGAT
GATGAGCTGGCCCTGGACCTGGAGGACTTGCTGAGCTTTTCTTACCAGGTGGCAAAAGGC
ATGGCGTTCCTTGCCTCAAAGAATTGTATTCATAGAGACTTGGCAGCCAGAAATATCCTC
CTTACTCATGGTCGAATCACAAAGATTTGTGATTTTGGTCTAGCCAGAGACATCAAGAAT
GATTCTAATTATGTGGTCAAAGGAAACGCTCGACTCCCTGTGAAGTGGATGGCACCAGAG
AGTATTTTCAACTGTGTATACACATTTGAAAGTGATGTCTGGTCCTATGGGATTTTTCTG
TGGGAGCTGTTCTCTTTAGGAAGCAGCCCCTACCCTGGAATGCCAGTCGATTCTAAGTTC
TACAAGATGATCAAGGAAGGTTTCCGAATGCTCAGCCCCGAGCATGCACCTGCGGAAATG
TATGACATCATGAAGACCTGCTGGGATGCTGATCCCTTGAAAAGGCCAACATTTAAGCAG
ATTGTGCAGCTGATTGAGAAGCAGATCTCAGAGAGCACCAATCATATTTATTCCAACTTA
GCAAACTGCAGCCCCCACCGGGAGAACCCCGCCGTGGACCATTCTGTGCGCATCAACTCT
GTGGGCAGCAGCGCCTCCTCCACGCAGCCTCTGCTTGTCCACGAAGATGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 977 |
| Molecular Weight
| 109685.0 |
| Theoretical pI
| 6.83 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Mast/stem cell growth factor receptor
MRGARGAWDFLFVLLLLLLVQTGSSQPSVSPGELSLPSIHPAKSELIVSVGDEIRLLCTD
PGFVKWTFEILGQLSEKTNPEWITEKAEATNTGNYTCTNKGGLSSSIYVFVRDPEKLFLI
DLPLYGKEENDTLVRCPLTDPEVTNYSLTGCEGKPLPKDLTFVADPKAGITIRNVKREYH
RLCLHCSANQRGKSMLSKKFTLKVRAAIKAVPVVSVSKTSYLLREGEEFAVTCLIKDVSS
SVDSMWIKENSQQTKAQTKKNSWHQGDFSYLRQERLTISSARVNDSGVFMCYANNTFGSA
NVTTTLEVVDKGFINIFPMMNTTVFVNDGENVDLVVEYEAYPKPVHRQWIYMNRTSTDKW
DDYPKSENESNIRYVNELHLTRLKGTEGGTYTFHVSNSDVNSSVTFNVYVNTKPEILTHD
RLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSVPVGPVDVQIQNSSVSPFGKLVVYSTID
DSTFKHNGTVECRAYNDVGKSSASFNFAFKGNSKEQIHAHTLFTPLLIGFVIAAGLMCIF
VMILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGA
FGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA
CTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEVALYKNLLHSKESSCNDSTN
EYMDMKPGVSYVVPTKADKRRSARIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKG
MAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPE
SIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM
YDIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPHRENPAVDHSVRINS
VGSSASSTQPLLVHEDV
|
| External Links |
|---|
| GenBank ID Protein
| BAA04084.1 |
| UniProtKB/Swiss-Prot ID
| P43481 |
| UniProtKB/Swiss-Prot Entry Name
| KIT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D16680 |
| GeneCard ID
| KIT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
