1.0 2018-05-07 22:25:49 UTC 2020-05-20 21:00:38 UTC BMDBP01184 Enzyme PLK4 Involved in ATP binding Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (By similarity). BMDB0001341 ADP 17 >2682 bp ATGGCGACCTGCATCGGAGAAAAGATCGAGGATTTTAGAGTTGGAAATCTGCTTGGTAAA GGATCATTTGCTGGTGTTTATAGAGCTGAGTCCATTCACACTGGTTTGGAAGTTGCAATC AAAATGATAGATAAGAAAGCCATGTACAAAGCTGGAATGGTACAGAGAGTCCAAAATGAG GTGAAAATACATTGCCAATTGAAACATCCTTCTATCTTGGAGCTGTATAACTATTTTGAA GATAACAATTATGTGTACCTAGTATTAGAAATGTGCCATAACGGAGAAATGAACAGGTAT TTAAAAAACAGAAGAAAACCATTCTCAGAAAATGAAGCTCGACACTTCATGCACCAAATC ATCACAGGAATGTTATATCTCCATTCACATGGTATATTACACCGGGACCTCACACTTTCT AACCTCTTACTTACACGTAATATGAACATCAAGATTGCTGATTTTGGGCTGGCAGCTCAG TTGAAAATGCCACATGAAAAGCACTATACATTATGTGGAACTCCTAATTACATTTCTCCA GAAATTGCAACTCGAAGTGCACATGGACTTGAATCTGATATTTGGTCCTTGGGCTGTATG TTTTATACGTTACTTATTGGGAGACCGCCTTTTGACACTGACACAGTCAAGAACACATTA AATAAAGTAGTATTGGCAGATTATGAAATGCCAACTTTTTTGTCAAGAGAAGCCAAGGAC CTTATTCACCAGTTACTTCGTAGAAATCCAGCAGATCGTTTAAGTCTGTCTTCAGTATTA GATCATCCTTTTATGTCCCGAAATTCTTCAAAAAAAAGCAAGGATTTAGGAACTGTAGAA GACTCGATTGATAGTGGACATGCCACAATTTCTACAGCAATTACAGCTTCTTCCAGTACC AGTATAAGTGGTAGTTTATTTGACAGAAGACGACTTTTGATTGAACAGCCACTCCCAAAT AAAATGACTATATTTCCAAAGAATAAAAATCCAAGTGATTTTTCTTCTTCAGGAGATGGA ATCAGCTTTTATACTTCATGGGGCAATCAAGAACAAGAAACCAGTAATAGTGGAAGGGGA AGAGTAATCCAAGAGGCAGAAGAAAGACCACATTCTCGATACCTTCGTAGAGCCCATTCG TCTGATAGATCTGAGACTTCTCATGGTCAGTCTAGAGTGAAAACATACACAATGGAACGA TGTTACTCAGCAGAAATGCTTTCAAAATCCAAACGATCAGGAGTGGAGGAAAATGAAAGA TACTCACCCACAAACAACGATGCTAATATTTTTCACTTCTTTAAGGAAAAAACATCCAAT AGTTCTGGATCTTTTGAAGGACCTGATAACAATCAAGCACTCTCCAATCATCTTTGTCCA GGAAAAACTCCCTTTCCATTTCCTGAACAGACACCTCAGACTGAAATGGTGCAACAATGG TTTGGGAATCTGCAAATAAATGATCCTTCTTGTGAACAAAGCAAGACTAGGGGTGTGGAG CCACCGTTGGTCTATCAGAAGCGTACATTACGAAGCATTACATCTCCTTTGACTGCTTAT AGGTTAAAACCAATCCGACAGAAAACCAAAAAGGCCGTGGTGAGCATACTTGATTCAGAG GAGGTATGTGTGGAGCTTCTGAAGGATTATGCATCTCAAGAATATGTGAAAGAAGTTCTT CAGATATCTAGTGACGGGAGTATGATCACTATTTATTATCCAAATGATGGAAGAGGTTTT CTTCTTGCTGATAGACCACCCTCACCTACTGATAACATCAGTAGGTACAGTTTTGATAAT TTACCAGAAAAGTACTGGCGAAAATATCAATATGCTTCCAGATTTGTACAGCTTGTAAGA TCTAAATCTCCTAAAATTACTTATTTTACAAGATATGCTAAATGTGTTTTGATGGAGAAT TCCCCTGGTGCTGATTTTGAGGTTTGGTTTTATGATGGAGCAAAGATACACAAAACAGAA GATTTAATTCAGGTGATCGAAAAGACTGGCAGATCTTACACCTTAAAAGGTGAAAGTGAA GTTAATAGCTTAAAAGAGGAGGTAAAAATGTATATGAACCATGCTAATGAGGGCCACCGT ATTTGTTTAGCACTGGAATCCATAATTTCAGAAGAGGAAAAGAAAAGTGGAAGTGCTCCC TTTTTCCCCATAATCGTAGGAAGAAGACCTAGTAGTACTAGTTCACCTAAGGCCTTAACA CCTCCTCCTCCTGTGGATCCAAACTACCCAATGAGAGAGACACCATCTCTGAATAGAATG ATCATAAATAGTGCTGCTTCTCCAAAACAGGCACCAGTACTTAATCCTCCTGTGGTTACA AATGAAGGACTTGGCCTTATGGGTGCAGCTTCTGAAACAAACAGCTCTCCTAGAAGTCTT AAAGATTGTCTCCCTAAATCAGCACAACTTTTGAAGTCTGTTTTTGTGAAAAATGTTGGT TGGGCTACACAGTTAACTAGTGGAGCTGTGTGGGTTCAGTTTAATGATGGGTCCCAGTTG GTCGTGCAGGCAGGAGTGTCTTCTATTAGTTATACATCACCAGATGGTCAAACAACTAGG TATGGAGAAAATGAAAAATTACCAGAATACATCAAACAGAAATTACAGTGTCTTTCTTCC ATCCTTTTGATGTTTTCTAATCCAACTCCTAGTTTTCATTGA 893 100707.0 8.84 None >Serine/threonine-protein kinase PLK4 MATCIGEKIEDFRVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNE VKIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRRKPFSENEARHFMHQI ITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAAQLKMPHEKHYTLCGTPNYISP EIATRSAHGLESDIWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPTFLSREAKD LIHQLLRRNPADRLSLSSVLDHPFMSRNSSKKSKDLGTVEDSIDSGHATISTAITASSST SISGSLFDRRRLLIEQPLPNKMTIFPKNKNPSDFSSSGDGISFYTSWGNQEQETSNSGRG RVIQEAEERPHSRYLRRAHSSDRSETSHGQSRVKTYTMERCYSAEMLSKSKRSGVEENER YSPTNNDANIFHFFKEKTSNSSGSFEGPDNNQALSNHLCPGKTPFPFPEQTPQTEMVQQW FGNLQINDPSCEQSKTRGVEPPLVYQKRTLRSITSPLTAYRLKPIRQKTKKAVVSILDSE EVCVELLKDYASQEYVKEVLQISSDGSMITIYYPNDGRGFLLADRPPSPTDNISRYSFDN LPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCVLMENSPGADFEVWFYDGAKIHKTE DLIQVIEKTGRSYTLKGESEVNSLKEEVKMYMNHANEGHRICLALESIISEEEKKSGSAP FFPIIVGRRPSSTSSPKALTPPPPVDPNYPMRETPSLNRMIINSAASPKQAPVLNPPVVT NEGLGLMGAASETNSSPRSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQL VVQAGVSSISYTSPDGQTTRYGENEKLPEYIKQKLQCLSSILLMFSNPTPSFH AAI33489.1 A2VDZ4 PLK4_BOVIN BC133488 PLK4