| Identification |
|---|
| BMDB Protein ID
| BMDBP01192 |
| Secondary Accession Numbers
| |
| Name
| Phosphatidylinositol 4-kinase alpha |
| Synonyms
|
Not Available
|
| Gene Name
| PI4KA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 1-phosphatidylinositol 4-kinase activity |
| Specific Function
| Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| PI4KA |
| Gene Sequence
|
>6132 bp
ATGTGCCCAGTAGATTTCCATGGGATCTTCCAGCTGGATGAGAGGCGGAGAGACGCAGTG
ATCGCATTGGGCATCTTTCTCATTGAATCTGACCTACAGCACAAAGACTCTGTGGTTCCT
TACCTTCTTCGACTTCTTAAAGGTCTTCCGAAAGTGTATTGGGTAGAAGAGAGCACAGCT
CGGAAGGGCAGAGGTACCCTCCCGGTGGCCGAGAGCTTGAGCTTCTGCTTGGTCACTCTG
CTGTCTGACGTGGCTTACAGGGACCCTTCCCTGAGGGGTGAGATCCTAGAGGCGCTGCTG
CAGGTCTTGCACGTGCTCCTGGGGATGTGCCAGGCCCTGGAGATTCAAGAGAAAGAGTAC
CTCTGCAAGCACGCGGTCCCGTGCCTGCTGGGAATCGTGCGCGCCTTTGGGCGGCACAGC
AGCTCGGAGGACTCGCTCCTGTCCAGGCTGTTCCCCAGAGCTCCTGCGCACTCCCCTCGT
GTCCCCGAGGAGCTGGAAGGTGTGCGCAGACGGTCCTTCAACGACTTCCGCTCCATCCTC
CCCAGCAGCCTGCTCACTGTGTGCCAGGAGGGCAGCCTGAAGAGGAAGGCCAGCAGCGCA
TCCAGCGTCGCACAGGTCAGCCCTGAGCGTGGGGCACCCCCTCCCAGCCCCCCTGGAGGA
TCTGCCTTTCACTGCCTCGAAGCCTCTTACTCACCCAATGGGAGCACCTCGGAATCCGAC
TACTACTTCTCTGCCGTCAGCTCCAGCCTCTCCGTCTCTCCTCTCTTCAACGGCGTCACC
TACAAAGAGTTCAGCATTCCCCTCGAGATGCTCCGGGAACTCTTAAACCTGGTGAAGAAG
ATCGTGGAGGAGCCTGTGCTCAAGTCTCTGGACGCAGTGGTCACGGGTGTTATCGAGGCC
AGCCCCAGTGCCGACCTCTGCCACGGCGCCTTCAGCGACCCCCTGTACGTGGCTGTGCTC
AGGATGCTGCGGGACACCCTGTACTACATGAGAGACCTGCCCACCTCCTTTGTGAAGGAG
GTGCACGACTTCGTGCTGGAGCAGTTCAACAGCAGCCAGGGGGAGCTCCAGAAGATCCTG
CACGATGCCGACCGGGCCCACAGCGAGCTGAGCCCCCTCAAGCTGCGCTGCCAGGCCAGT
GCCGCCTGCGTGGACCTCATGGTCTGGGCAGTGAAGGACGAGCAGGGTGCAGAGAATCTG
TGCGTCAAGCTATCTGAGAAGCTGCAGTCCAAGACGTCCAGCAAGGTCATCATCGCGCAG
GTGCCACTGCTCATCTGCTGTCTGCAGGGCCTGGGCCGCCTGTGCGAGCGGTTCCCGGTG
GTGGTGCACTCGGTGACACCCTCCCTGCGGGACTTCCTGGTGGTCCCATCCCCCGTGCTG
GTGAAGCTGTACAAGTGCCACAGCCAGTACCACACAGTTGCCGGCAATGACATAAAAATC
AGCGTAACCAATGAGCATGCCGAGTCGACCCTAAATGTGGCATCGGGGAAGAAGAGCCAG
CCGTCCATGTATGAGCAGCTTCGGGACATTGCCATCGACAATGTCTGCAGGTGCCTGAAG
GCGGGCCTGACCGAGGACCCAGTGATCGTGGAGGCCTTCCTGGCCAGCCTCTCCAACCGG
CTGTACATCTCCCAGGAGAGCGATAAGGATGCACACCTGATTCCTGACCACACCATCCGA
GCCTTGGGACACATCGCGGTGGCCCTGAGGGACACCCCAAAGGTCATGGAGCCCATTCTG
CAGATCCTGCAGCAGAAATTCTGCCAGCCCCCCTCCCCGCTTGACGTGCTCATCATCGAC
CAGCTGGGCTGCCTGGTCATCACCGGAAACCAATATATTTACCAGGAGGTGTGGAACCTC
TTTCAGCAGATCAGCGTGAAGGCCAGCTCGGTTGTGTACTCGGCCACCAAGGACTACAAG
GACCATGGCTACAGGCACTGCTCGCTGGCGGTGATCAACGCCCTGGCCAACATCGCGGCC
AACATCCAGGATGAGCACCTCGTGGACGAGCTGCTCATGAACCTGCTGGAGCTGTTTGTG
CAGCTGGGGCTGGAGGGGAAGCGGGCCAGTGAGCGGGCCAGCGAGAAGGGGCCCGCCCTC
AAGGCCTCCAGCAGTGCGGGGAACCTGGGCGTGCTCATCCCTGTGATCGCAGTGCTCACC
CGGCGGCTGCCGCCCATCGAGGAGCCGAAGCCGAGGCTGCAGAAGCTCTTCCGGGACTTC
TGGCTGTACTCGGTGCTGATGGGGTTCGCCGTGGAGGGCTCAGGACTCTGGCCCGAGGAG
TGGTACGAGGGGGTCTGTGAGATCGCCACCAAGTCCCCGCTGCTCACCTTTCCCAGCAAA
GAGCCTCTGCGGTCCGTCCTCCAGTACAACTCGGCCATGAAGAACGACACGGTTACGCCT
GCCGAGCTGAGTGAGCTGCGCAGCACCATCGTCAACCTTCTGGACCCGGCCCCCGAGGTG
TCCGCCCTCATCGGCAAGCTGGACTTCGCCATGTCCACCTACCTGCTGTCCGTCTACCGG
CTGGAGTACATGAGGGTCCTGCGCTCCAGCGACCCCGCCCGCTTCCAGGTGATGTTGTGC
TACTTCGAGGACAAGGCCATCCAGAAGGACAAGTCCGGGATGATGCAGTGTGTGATCGCC
GTCGCCGACAAGGTGTTCGACGCCTTCCTGAACATGATGGCGGAGAAAGCCAAGACCAAG
GAGAACGAGGAGGAGCTGGAGCGCACGCAGTTCCTGCTGGTCAGCTTCAACCACGTCCAC
AAGCGCATCCGCAGGGTCGCCGACAAGTACCTGTCTGGGCTGGTGGACAAGTTCCCCCAC
TTGCTCTGGAGCGGGACGGTGCTGAAGACCATGCTGGACATCCTGCAGACCCTGTCCCTG
TCGCTGAGTGCTGACATCCACAAGGACCAGCCATACTACGACATTCCCGACGTGCCCTAC
CGCATCACCGTCCCGGACACCTACGAGGCCCGAGAGAGCATCGTCAAAGACTTCGCCGCG
CGCTGCGGGATGATCCTTCAGGAGGCCATGAAGTGGGCGCCCACGGTCACCAAGTCCCAC
CTGCAGGAGTACCTGAGCAAGCACCAGAACTGGGTATCGGGGCTGTCGCAGCACACGGGG
CTGGCCATGGCCACCGAGAGCGTCCTGCACTACTCCGGCTACAACAAGCAGAGCACGAGC
CTCGGGGCGACACAGCTCACAGAACGGCCAGCCTGTGTCAAGAAGGACTACTCCAACTTC
ATGGCTTCCCTGAACCTGCGCAACCGCTATGCGGCCGAGGTGTACGGGATGATCCGGTTC
TCGGACGCCACAGGCCACACATCGGACCTGAACAAGATGATGGTCCAGGAGCTGAAGGCT
GCGCTGGGCGCCGGCGACGCTCAGCAGTACACGCAGGCCATGTTCAAGCTGACGGCCATG
CTCATCAGCAGCAGAGACTGTGACCCGCAGCTCCTCCACCACCTGTGCTGGGGCCCCCTG
CAGATGTTCAACGAGCACGGCATGGAGACCGCCCTGGCCTGCTGGGAGTGGCTGCTGGCC
GGCAAGAACGGGGTGGAAGTGCCGTTCATGCGGGAGATGGCGGGGGCCTGGCAGATGACC
GTGGAGCAGAAGTTCGGCCTGTTTTCTGCGGAGATGAAGGAAGCAGACCCCTTGGCCGCA
TCAGAAGCCAGTCAGCCCAAACCGTGTGCCCCCGAGGTGACCCCTCACTACATCTGGATC
GACTTCCTGGTACAGCGGTTTGAGATTGCCAAGTACTGCAGTTCCGACCAGGTGGAGATC
TTCTGCAGCCTCCTGCAGCGCTCCCTGTCCCTGAGCATCGGGGGCACCGCGGGCAGCATG
AACCGGCATGTGGCGGCCATCGGGCCCCGCTTCAAGCTGCTGACCCTCGGCCTGTCCCTG
CTGCACGCGGACGTGCTGCCCAACGCCACCATCCGCAACGTGCTCCGCGAGAAGATCTAC
TCCACCGCCTTTGACTACTTCAGCTGCCCGCCGAGGTTCCCGACCCAGGGGGAGAAGAGG
CTGCGTGAGGACATCAGCGTGATGATCAAGTTCTGGACCGCAATGTTCTCAGACAAGAAG
TACCTGACCGCCAGCCAGCTCGTTCCCCCAGACAACCAGGACACCCGGAGCAACCTGGAC
ATCGCGGTCGGCTCTCGCCAGCAGGCCACGCAGGGCTGGATCAACACGTACCCGCTGTCC
AGCGGCATGTCCACCATCTCCAAGAAATCGGGCATGTCCAAGAAGACCAACCGGGGCTCC
CAGCTGCACAAGTATTACATGAAGCGCCGGACGCTGCTGCTGTCACTGCTGGCCACCGAG
ATCGAGCGCCTCATCACCTGGTACAACCCGCTGTCCGCCCCGGAGCTGGAGCTGGACCAG
GCGGGGGAGAGCAGCGTGGCCAACTGGAGGTCCAAGTACATCAGCCTGAGCGAGAAGCAG
TGGAAGGACAACGTGAACCTCGCCTGGAGCATCTCGCCCCACCTGGCCGTGCAGCTGCCA
GCCAGGTTCAAGAACACGGAGGCTATCGGCAACGAGGTGACACGTCTGGTGCGCTTGGAC
CCAGGAGCCGTTAGTGACGTCCCGGAAGCCATCAAGTTCCTGGTCACCTGGCACACCATC
GACGCCGACGCCCCCGAGCTCAGCCACGTGCTGTGCTGGGCGCCCGCGGACCCACCCACA
GGCCTGTCCTACTTCTCCAGCATGTCCCCGCCGCACCCCCTCACGGCGCAGTACGGGGTC
AAGGTCCTGAGGTCCTTTCCGCCGGACGCCATCCTGTTCTACATTCCCCAGATTGTGCAG
GCGCTCAGGTATGACAAGATGGGCTACGTGCGGGAGTACATCCTGTGGGCCGCCTCCCAG
TCCCAGCTACTGGCACACCAGTTCATCTGGAACATGAAGACCAACATCTACGTGGACGAA
GAAGGCCACCAGAAGGACCCCGACATCGGTGACCTCCTGGAGCAGCTGGTGGAGGAGATC
ACAGGCTCCCTCTCCGGCCCGGCCAAGGACTTCTACCAGCGGGAGTTCGACTTTTTCAAC
AAGATCACCAACGTGTCGGCCATCATCAAGCCCTACCCCAAAGGCGACGAGAGGAAGAAG
GCCTGCCTGTCGGCCTTGTCTGAAGTGAAGGTGCAGCCTGGCTGCTACCTGCCCAGCAAC
CCCGAGGCCATCGTGCTGGACATCGACTACAAGTCTGGGACGCCCATGCAGAGTGCCGCC
AAGGCCCCGTATCTGGCGAAGTTCAAGGTGAAACGTTGCGGGGTTAGTGAGCTTGAGAAG
GAAGGCCTGCGGTGCCGCTCAGACCCCGAGGAGGAGGGCAGCATGCAGGAGGCCGACGGC
CAGAAGATCTCCTGGCAGGCGGCCATCTTCAAAGTGGGGGACGACTGCCGGCAGGACATG
CTGGCCCTGCAGATCATCGACCTCTTCAAAAACATCTTCCAGCTGGTCGGCCTGGACCTC
TTCGTCTTCCCGTACCGGGTGGTGGCCACCGCCCCCGGGTGCGGCGTCATCGAGTGCATC
CCCGACTGCACCTCCCGGGACCAGCTGGGCCGCCAGACCGACTTTGGCATGTACGACTAC
TTCACGCGCCAGTACGGGGACGAGTCCACACTGGCCTTCCAGCAGGCGCGCTACAACTTC
ATCCGCAGCATGGCCGCCTACAGCCTCCTCCTGTTCCTGCTGCAGATCAAGGACCGGCAC
AACGGCAACATCATGCTGGATAAGAAGGGCCACCTCATCCACATCGATTTCGGCTTCATG
TTCGAAAGCTCCCCGGGCGGCAACCTCGGCTGGGAGCCGGACATCAAGCTGACGGACGAG
ATGGTGATGATCATGGGGGGCAAGATGGAGGCCACGCCCTTCAAGTGGTTCATGGAGATG
TGTGTCCGTGGCTACCTGGCTGTGCGGCCCTACATGGACGCTGTGGTCTCTCTGGTCACT
CTCATGCTGGACACGGGCCTGCCCTGCTTCCGTGGCCAGACAATCAAGCTCCTCAAGCAC
AGGTTCAGCCCCAACATGACGGAGCGAGAGGCCGCGAACTTCATCCTGAAGGTCATTCAG
AACTGCTTCCTCAGCAACAGGAGCCGGACCTACGACATGATCCAGTACTATCAGAACGAC
ATCCCCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2102 |
| Molecular Weight
| 235149.0 |
| Theoretical pI
| 6.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol 4-kinase alpha
MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDSVVPYLLRLLKGLPKVYWVEESTA
RKGRGTLPVAESLSFCLVTLLSDVAYRDPSLRGEILEALLQVLHVLLGMCQALEIQEKEY
LCKHAVPCLLGIVRAFGRHSSSEDSLLSRLFPRAPAHSPRVPEELEGVRRRSFNDFRSIL
PSSLLTVCQEGSLKRKASSASSVAQVSPERGAPPPSPPGGSAFHCLEASYSPNGSTSESD
YYFSAVSSSLSVSPLFNGVTYKEFSIPLEMLRELLNLVKKIVEEPVLKSLDAVVTGVIEA
SPSADLCHGAFSDPLYVAVLRMLRDTLYYMRDLPTSFVKEVHDFVLEQFNSSQGELQKIL
HDADRAHSELSPLKLRCQASAACVDLMVWAVKDEQGAENLCVKLSEKLQSKTSSKVIIAQ
VPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVVPSPVLVKLYKCHSQYHTVAGNDIKI
SVTNEHAESTLNVASGKKSQPSMYEQLRDIAIDNVCRCLKAGLTEDPVIVEAFLASLSNR
LYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIID
QLGCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAA
NIQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLT
RRLPPIEEPKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSK
EPLRSVLQYNSAMKNDTVTPAELSELRSTIVNLLDPAPEVSALIGKLDFAMSTYLLSVYR
LEYMRVLRSSDPARFQVMLCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTK
ENEEELERTQFLLVSFNHVHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSL
SLSADIHKDQPYYDIPDVPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSH
LQEYLSKHQNWVSGLSQHTGLAMATESVLHYSGYNKQSTSLGATQLTERPACVKKDYSNF
MASLNLRNRYAAEVYGMIRFSDATGHTSDLNKMMVQELKAALGAGDAQQYTQAMFKLTAM
LISSRDCDPQLLHHLCWGPLQMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWQMT
VEQKFGLFSAEMKEADPLAASEASQPKPCAPEVTPHYIWIDFLVQRFEIAKYCSSDQVEI
FCSLLQRSLSLSIGGTAGSMNRHVAAIGPRFKLLTLGLSLLHADVLPNATIRNVLREKIY
STAFDYFSCPPRFPTQGEKRLREDISVMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLD
IAVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATE
IERLITWYNPLSAPELELDQAGESSVANWRSKYISLSEKQWKDNVNLAWSISPHLAVQLP
ARFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPADPPT
GLSYFSSMSPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASQ
SQLLAHQFIWNMKTNIYVDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFN
KITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAA
KAPYLAKFKVKRCGVSELEKEGLRCRSDPEEEGSMQEADGQKISWQAAIFKVGDDCRQDM
LALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDY
FTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHLIHIDFGFM
FESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVT
LMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFILKVIQNCFLSNRSRTYDMIQYYQND
IPY
|
| External Links |
|---|
| GenBank ID Protein
| AAC48730.1 |
| UniProtKB/Swiss-Prot ID
| O02811 |
| UniProtKB/Swiss-Prot Entry Name
| PI4KA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U88532 |
| GeneCard ID
| PI4KA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
