| Identification |
|---|
| BMDB Protein ID
| BMDBP01242 |
| Secondary Accession Numbers
| None |
| Name
| Gamma-glutamylcyclotransferase |
| Synonyms
|
Not Available
|
| Gene Name
| GGCT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. |
| Pathways
|
|
| Reactions
|
| Gamma-Glutamylcysteine → L-Cysteine + Pyroglutamic acid |
details
|
| 5-L-Glutamyl-L-alanine → Pyroglutamic acid + L-Alanine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| GGCT |
| Gene Sequence
|
>567 bp
ATGGCGAACTTCGGCTGCGAGGACCTCCGGAGTCAGGATGGGGAGAGTTTTCTCTACTTT
GCCTATGGCAGCAACCTGCTGACGGAGCGGATCCACCTCCGAAACCCCTCCGCCGTGTTC
TACAGCGTAGCCCGCTTGCAGGATTTTAAACTTGACTTTGGCAATCCCCAAGGCAAAACA
AGTGAAACTTGGCATGGAGGTATAGCCACCATTTTTGAAAGTCCTGGCGATGAAGTATGG
GGAGTAGTATGGAAAATGAACAAAAGCAATTTAAGTTCTCTGGATAAGCAAGAAGGGGTT
AAAAGTGGAATGTATGTCCCAATAGAAGTTACTGTTTCAACTCAAGAAGGAAAAGAAATA
ACCTGTCGAAGTTATCAGATGACAAATTATGAGAGTGTTCCCCCATCACCCCAGTATAAA
AAGGTCATTTGCATGGGCGCAAAAGAGAATGGTTTGCCCCTGGAGTACCAAAAGAAGTTA
AATTCAATAGAACCAAATGACTACAAAGGAAAGGTCTCAGAAGAAATCGAAGACATTATC
AAAAAGGGGGAAGCAAAGACTCATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 188 |
| Molecular Weight
| 21177.0 |
| Theoretical pI
| 5.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Gamma-glutamylcyclotransferase
MANFGCEDLRSQDGESFLYFAYGSNLLTERIHLRNPSAVFYSVARLQDFKLDFGNPQGKT
SETWHGGIATIFESPGDEVWGVVWKMNKSNLSSLDKQEGVKSGMYVPIEVTVSTQEGKEI
TCRSYQMTNYESVPPSPQYKKVICMGAKENGLPLEYQKKLNSIEPNDYKGKVSEEIEDII
KKGEAKTH
|
| External Links |
|---|
| GenBank ID Protein
| AAI09623.1 |
| UniProtKB/Swiss-Prot ID
| Q32LE4 |
| UniProtKB/Swiss-Prot Entry Name
| GGCT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109622 |
| GeneCard ID
| GGCT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
