| Identification |
|---|
| BMDB Protein ID
| BMDBP01251 |
| Secondary Accession Numbers
| None |
| Name
| Methionine--tRNA ligase, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| MARS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus. |
| Pathways
|
- Methionine Metabolism
- Protein Synthesis: Methionine
- Selenoamino Acid Metabolism
|
| Reactions
|
| Selenomethionine + Adenosine triphosphate + tRNA(Met) → Selenomethionyl-tRNA(Met) + Adenosine monophosphate + Pyrophosphate |
details
|
| L-Methionine + Adenosine triphosphate + tRNA(Met) → L-Methionyl-tRNA(Met) + Adenosine monophosphate + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| MARS1 |
| Gene Sequence
|
>2697 bp
ATGAGGTTGTTCGTGAGTGAGGGCGCTCCGGGGAGTCTGCCTGTGCTGGCCGCGGCCGGG
AGGGCCCAGGGCAGAGCGGAGCTGCTCATCAGCACTGTAGGCCCAGAAGAGTGTGTGGTC
CCATTCCTGACCCGGCCTAAGGTCCCTGTCTTGCAGCTGGATAGTGGCAACTACCTCTTC
TCCACCAGTGCAATCTGTCGATACTTCTTTCTGTTATCTGGCTGGGAGCAAGATGACCTC
ACCAACCAGTGGCTGGAATGGGAAGCAACCGAGCTGCAGCCAGCTTTGTCCGCTGCCCTG
TACTATTTAGTGGTCCAAGGGAAGAAGGGAGAAGATGTTCTTGGCCCAGTTCGGAGAGCC
CTGACGCATATTGACCACAGCTTGAGTCGTCGGAGCTGTCCGTTCCTGGCTGGGGAGACA
GAATCTCTAGCTGATATTGTTTTGTGGGGAGCGCTCTACCCGTTACTCCAAGACCCATCC
TATCTCCCTGAGGAGCTGGGTGCCCTGCACAGCTGGTTCCAGACACTGAGTTCTCAGGAG
CCATGTCAGCGAGCTGCAGAGACTGTGCTGAAGCAGCAGGGTGTCCTGGCCCTCCGGCCC
TACCTCCAGAAGCAGCCCCAGCCCAGCTCCCTTGAGGGCAGGCTTGTCAGCAATGAGCCT
GAGGAGGAGGAACTGGCTACTCTGTCTGAGGAGGAGATTGCCGTGGCTGTAGCTGCTTGG
GAGAAGGGCCTGGAAAGCTTGCCCCCTCTTCGGCCGCAGCAGAATCCAGTGTTGCCCGTG
GCTGGGGAGAGAAATGTGCTCATCACCAGCGCCCTCCCTTACGTCAACAACGTCCCCCAC
CTTGGAAACATCATCGGCTGTGTGCTCAGTGCCGACGTCTTTGCAAGGTACTCCCGGCTC
CGTCAGTGGAACACCCTCTACCTGTGTGGGACAGATGAGTATGGTACAGCGACAGAGACC
AAGGCTATGGAGGAGGGACTAACCCCACAGGAAATCTGTGACAAGTACCACGTAATCCAC
GCTGACATCTACCGCTGGTTTAATATTTCGTTTGACTTTTTTGGTCGGACTACCACTCCA
CAGCAGACCAAAATTACCCAGGACATCTTCCAGCGGCTGTTGGCCCGAGGTTTTGTGCTG
CAAGATACTGTGGAGCAACTTCGGTGTGAGCACTGTGCCCGCTTCCTGGCTGACCGCTTT
GTGGAGGGTGTGTGTCCCTTCTGTGGATACGAGGAAGCCCGGGGTGACCAGTGTGACAAG
TGTGGCAAGCTCATTAATGCCATTGAGCTCAAGAAGCCTCAGTGTAAAGTCTGCCGGTCG
TGCCCTGTGGTGAAATCCTCTCAGCACCTGTTTCTGGACCTGCCTAAGCTGGCAGCGCGG
GTGGAGGAGTGGTTGGAGAAGACATTGCCTGGCAGTGACTGGACTGCCAACGCCCGGTTC
ATCATTCGTTCTTGGCTTCGAGATGGCCTCAAGCCCCGCTGTATAACCCGAGACCTCAAG
TGGGGAACCCCTGTGCCCTTAGAAGGTTTTGAGGACAAGGTGTTCTATGTCTGGTTTGAT
GCCACCATTGGCTATCTGTCCATCACAGCCAACTACACAGACCAATGGGAGAAGTGGTGG
AAGAACCCAGAACAAGTGAACCTGTATCAGTTCATGGCCAAGGACAATGTTCCCTTCCAT
GGCATAGTCTTTCCTTCTTCAGCCCTAGGAGCTGAGGACAACTACACCTTGGTCAGCCAC
CTCATTGCTACAGAGTATCTGAATTACGAGGATGGGAAATTCTCTAAGAGCCGGGGTGTG
GGAGTGTTTGGGGACATGGCCCAGGACACAGGGATCCCTGCTGACATCTGGCGCTTCTAT
CTGCTGTACAATCGGCCTGAGGGGCAGGACAGTGCCTTCTCCTGGACAGACATGTTGTTC
AAGAATAATTCCGAGCTGCTTAACAACCTGGGCAACTTCATCAACAGAGCTGGGATGTTT
GTGTCCAAGTTTTTTGGGGGTTTTGTGCCTGAGATGGTGCTCACCTCTGATGATCAGCGC
CTGCTGACCCATATCACCCTGGAGCTCCAGCACTACCACCAGCTGCTAGAGAAGGTTCGG
ATCCGGGATGCCTTACGTAGCATCCTCACCATCTCTCGCCATGGCAACCAGTACATTCAG
GTGAACGAGCCCTGGAAGCGGATTAAAGGTGGCGAAGCTGACAGGCAGCGGGCAGGGACA
GTGACAGGCTTGGCCGTGAATATAGCTGCCTTGCTGTCCGTCATGCTCCAGCCTTACATG
CCTACAGTTAGTGCCACCATCCAAGCCCAGCTGCAGCTCCCACCTCCAGCCTGCAGTATC
CTGCCCACAAACTTCCTATGCACCTTACCAGCAGGACACCAGATTGGCACGGTCAGTCCC
TTGTTCCAAAAATTGGAAAATGACCAGATTGAAAGTCTGAAGCAGCGCTTCAGTGGGGGC
CAGGCAAAAGCATCCCCCAAGACAGCAGCTGGACTGACAACAGCTGGACCGCAGCAGATC
CAAGCACTGACAGAGGAAGTGACCAAGCAGGGCAATATTGTCCGAGAATTGAAGGCACAG
AAGGCAGACAAGAACCAGATTGCTGCAGAGGTGGCTAAACTCTTGGATCTGAAGAAACAG
TTGGCTCTAGCTGAGGGGAAACCCCTGGAAACCTCTAAAGGCAAGAAGAAAAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 898 |
| Molecular Weight
| 100634.0 |
| Theoretical pI
| 6.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Methionyl-tRNA synthetase, cytoplasmic
MRLFVSEGAPGSLPVLAAAGRAQGRAELLISTVGPEECVVPFLTRPKVPVLQLDSGNYLF
STSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGPVRRA
LTHIDHSLSRRSCPFLAGETESLADIVLWGALYPLLQDPSYLPEELGALHSWFQTLSSQE
PCQRAAETVLKQQGVLALRPYLQKQPQPSSLEGRLVSNEPEEEELATLSEEEIAVAVAAW
EKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRL
RQWNTLYLCGTDEYGTATETKAMEEGLTPQEICDKYHVIHADIYRWFNISFDFFGRTTTP
QQTKITQDIFQRLLARGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDK
CGKLINAIELKKPQCKVCRSCPVVKSSQHLFLDLPKLAARVEEWLEKTLPGSDWTANARF
IIRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWEKWW
KNPEQVNLYQFMAKDNVPFHGIVFPSSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGV
GVFGDMAQDTGIPADIWRFYLLYNRPEGQDSAFSWTDMLFKNNSELLNNLGNFINRAGMF
VSKFFGGFVPEMVLTSDDQRLLTHITLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQ
VNEPWKRIKGGEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSI
LPTNFLCTLPAGHQIGTVSPLFQKLENDQIESLKQRFSGGQAKASPKTAAGLTTAGPQQI
QALTEEVTKQGNIVRELKAQKADKNQIAAEVAKLLDLKKQLALAEGKPLETSKGKKKK
|
| External Links |
|---|
| GenBank ID Protein
| AAI11363.1 |
| UniProtKB/Swiss-Prot ID
| Q2T9L8 |
| UniProtKB/Swiss-Prot Entry Name
| SYMC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111362 |
| GeneCard ID
| MARS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
