| Identification |
|---|
| BMDB Protein ID
| BMDBP01256 |
| Secondary Accession Numbers
| None |
| Name
| cGMP-dependent 3',5'-cyclic phosphodiesterase |
| Synonyms
|
Not Available
|
| Gene Name
| PDE2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 3',5'-cyclic-nucleotide phosphodiesterase a |
| Specific Function
| Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| PDE2A |
| Gene Sequence
|
>2766 bp
ATGCGCCGACAGCCTGCAGCCAGCCGGGACCTCTTTGCACAGGAGCCAGTGCCCCCAGGG
AGTGGAGACGGCGCATTGCAGGATGCTTTGCTGAGCCTGGGCTCCGTCATCGACGTTGCA
GGCTTGCAACAGGCTGTCAAGGAGGCCCTGTCGGCTGTGCTTCCCAAAGTGGAGACGGTC
TACACCTACCTGCTGGATGGGGAATCCCGGCTGGTGTGTGAGGAGCCCCCCCACGAGCTG
CCCCAGGAGGGGAAAGTGCGAGAGGCTGTGATCTCCCGGAAGCGGCTGGGCTGCAATGGA
CTGGGCCCCTCAGACCTGCCTGGGAAGCCCTTGGCAAGGCTGGTGGCTCCACTGGCTCCT
GACACCCAAGTGCTGGTCATACCGCTGGTGGACAAGGAGGCCGGGGCTGTGGCAGCTGTC
ATCTTGGTGCACTGTGGTCAGCTGAGTGACAATGAGGAGTGGAGCCTGCAAGCTGTGGAG
AAGCATACCCTGGTGGCCCTGAAAAGGGTGCAGGCCTTGCAGCAGCGCGAGTCCAGCGTG
GCCCCGGAAGCGACCCAGAATCCTCCGGAGGAGGCAGCGGGAGACCAGAAGGGTGGGGTC
GCATACACAAACCAAGACCGAAAGATCCTGCAGCTTTGCGGGGAGCTCTACGACCTGGAT
GCATCTTCCCTGCAGCTCAAAGTCCTCCAATATCTGCAACAGGAGACCCAGGCATCCCGC
TGCTGCCTGCTGCTGGTATCCGAGGACAATCTTCAGCTCTCCTGCAAGGTCATTGGAGAT
AAAGTACTGGAGGAAGAGATCAGCTTTCCGTTGACCACAGGACGCCTGGGCCAAGTGGTG
GAAGACAAGAAGTCTATCCAGCTGAAAGATCTCACCTCCGAGGATATGCAACAGCTGCAA
AGCATGTTGGGCTGTGAGGTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACT
GACCAGGTCGTGGCCCTGGCCTGTGCCTTCAACAAGCTCGGAGGAGACTTGTTCACAGAC
CAGGACGAGCACGTGATCCAGCACTGCTTCCACTACACCAGCACAGTGCTCACCAGCACC
CTGGCCTTCCAGAAGGAGCAGAAGCTCAAGTGTGAGTGCCAGGCTCTTCTCCAAGTGGCG
AAGAACCTCTTCACTCATCTGGATGACGTCTCCGTGCTGCTCCAGGAGATCATCACAGAG
GCCAGGAACCTCAGCAATGCTGAGATCTGCTCTGTGTTCCTGCTGGATCAGAACGAGCTG
GTGGCCAAGGTGTTCGATGGGGGTGTGGTGGAAGATGAGAGCTATGAGATCCGCATTCCC
GCTGACCAGGGCATCGCGGGTCATGTGGCGACCACCGGCCAGATCCTAAACATCCCAGAT
GCTTACGCACATCCGCTTTTCTACCGAGGCGTGGACGACAGCACCGGCTTCCGGACGCGC
AACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGAGGTCATCGGTGTGGCCGAGCTG
GTGAACAAGATCAATGGACCATGGTTCAGCAAGTTTGATGAAGACCTGGCTACAGCCTTC
TCCATCTACTGTGGCATCAGCATTGCCCATTCCCTCCTATACAAGAAAGTGAATGAGGCG
CAGTATCGCAGCCACCTTGCCAATGAGATGATGATGTACCACATGAAGGTCTCTGATGAC
GAGTACACCAAACTTCTCCATGACGGGATCCAGCCTGTGGCTGCCATCGACTCCAACTTT
GCCAGTTTCACATACACTCCTCGCTCTCTGCCCGAGGATGACACTTCCATGGCCATCCTG
AGCATGCTGCAGGACATGAATTTCATCAATAACTACAAAATTGACTGCCCGACACTGGCC
CGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCAC
GCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTAC
CTCGAGGACATGGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCACGACCTGGACCAC
AGAGGCACAAACAACTCCTTCCAGGTGGCCTCGAAATCTGTGCTGGCCGCGCTCTACAGC
TCGGAAGGCTCTGTCATGGAGAGGCACCACTTCGCTCAGGCCATTGCCATCCTCAACACC
CACGGCTGCAACATCTTTGACCACTTCTCCCGGAAGGATTATCAGCGCATGTTGGACCTG
ATGCGGGACATCATCTTGGCCACAGATCTGGCCCACCACCTCCGCATCTTCAAGGACCTC
CAAAAGATGGCCGAAGTGGGCTATGATCGAACCAACAAGCAGCACCACAGCCTCCTTCTC
TGCCTCCTTATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACCACGAGG
AAGATCGCGGAGCTGATCTACAAAGAGTTCTTCTCCCAGGGAGACTTGGAGAAGGCCATG
GGCAACAGGCCGATGGAGATGATGGACCGTGAGAAGGCCTACATCCCCGAGCTGCAGATC
AGCTTCATGGAGCACATCGCAATGCCCATCTACAAGCTGCTGCAAGACCTGTTCCCCAAG
GCGGCCGAGTTGTACGAACGCGTGGCCTCTAATCGTGAGCACTGGACCAAGGTGTCACAC
AAGTTCACCATCCGAGGCCTCCCGAGCAACAACTCGTTGGACTTCCTGGACGAGGAGTAT
GAGGTGCCTGACCTGGATGGCGCTAGGGCTCCCATCAATGGCTGTTGCAGCCTTGATGCT
GAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 921 |
| Molecular Weight
| 103228.0 |
| Theoretical pI
| 4.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>cGMP-dependent 3',5'-cyclic phosphodiesterase
MRRQPAASRDLFAQEPVPPGSGDGALQDALLSLGSVIDVAGLQQAVKEALSAVLPKVETV
YTYLLDGESRLVCEEPPHELPQEGKVREAVISRKRLGCNGLGPSDLPGKPLARLVAPLAP
DTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALKRVQALQQRESSV
APEATQNPPEEAAGDQKGGVAYTNQDRKILQLCGELYDLDASSLQLKVLQYLQQETQASR
CCLLLVSEDNLQLSCKVIGDKVLEEEISFPLTTGRLGQVVEDKKSIQLKDLTSEDMQQLQ
SMLGCEVQAMLCVPVISRATDQVVALACAFNKLGGDLFTDQDEHVIQHCFHYTSTVLTST
LAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNEL
VAKVFDGGVVEDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTR
NILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEA
QYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAIL
SMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNY
LEDMEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNT
HGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRTNKQHHSLLL
CLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQI
SFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEY
EVPDLDGARAPINGCCSLDAE
|
| External Links |
|---|
| GenBank ID Protein
| AAA74559.1 |
| UniProtKB/Swiss-Prot ID
| P14099 |
| UniProtKB/Swiss-Prot Entry Name
| PDE2A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M73512 |
| GeneCard ID
| PDE2A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
