| Identification |
|---|
| BMDB Protein ID
| BMDBP01292 |
| Secondary Accession Numbers
| None |
| Name
| Plasma kallikrein |
| Synonyms
|
Not Available
|
| Gene Name
| KLKB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase activity |
| Specific Function
| The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin (By similarity). |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| KLKB1 |
| Gene Sequence
|
>1911 bp
ATGATTGCACTCAGGCAAGCAGCTTACTTCATTTGCCTGTTTGCTACAGTTTCCTGTGGA
TGCTTGACTCAACTATATCACAACATCTTCTTCAGAGGTGGGGATGTATCAGCCATGTAC
ACCCCAGATGCCCAATACTGTCAGCTGATGTGCACCTTCCACCCTAGGTGCTTGCTCTTT
AGTTTTCTTCCTGAAAATTCAACCAGTGATGCAGACAAAAGGTTTGGTTGCTTCTTGAAG
GACAGTGTTACAGGAACCCTGCCGAGAGTGTCACGGACAGGTGCAATTTCGGGACATTCT
TTAAAGCGATGTGGTCATCAAATTAGTGCTTGCCACCGAAGCATTTATAAAGGAATCGAT
ATGAGAGGAGTCAATTTCAATGCATCTAAGGTGAGAAGTGCCAAAGAATGCCAAGAAAGG
TGCACCAACAACATTCACTGCCAGTTCTTCACATATGCCACGAAAACCTTCTTCAGTGCA
GAGTACCGGAACACCTGCCTATTAAAACGGAGCCCACAGGGGACACCCACGCGTATAAAG
GTGCTGAGTGATGTGGAGTCTGGATTCTCACTGAAGGCCTGTGGAAACTCGAAAATTGGC
TGCCGCGTGGACATTTTCCAACACAGTGCGTTTTCAGATGTGGATGTTGCCGGAATTATC
GCACCAGATGCTTTTGTGTGTCGAACCATCTGCACCTATCACCCCAGCTGTCTTTTCTTC
ACATTCTATACAAATGCATGGAAGACAGACTCACAGAGAAATGTTTGTTTCCTTAAGACT
TCCCAAAGTGGGAGCCCGAGTTCCCCTACTCCTCAGGAAAATGCCATCTCTGGATACAGC
CTTCTAACCTGCAAACAAACTCTGCCTGGCACAGAGCCCTGCCACTCCAAAATTTACCCG
CAAGTTGCTTTCGAAGGAGAAGAGCTGCATGTGACCTTCGTGAAAGGAGTGGATGGTTGC
CAAGAGACCTGTACAAAGATGATTCGCTGTCAGTTTTTTACTTATTCTTTATTCCCAGAA
GACTGTAGAGGAGAGAAGTGTAAATGTTCCTTACGCTTGTCTTTGGATGGCTCCCCAACT
AACATTACTTATGGGACGCAAGCAAGCTCTGGTTATTCCTTGAGGTTGTGTAAACGTGGG
GACAGCCGTGTCTGTACAACAAAAAGGACACGCATTGTTGGAGGAACAAATGCTTCTTGG
GGAGAGTGGCCCTGGCAGGTTAGCCTGCAAGTGAAGCAGAGAGCTCAGAGCCACCTGTGC
GGAGGGTCAATTATTGGACGCCAGTGGGTCTTAACTGCTGCCCATTGCTTCGATGGGCTT
CTCTTGTCAAATATTTGGCGCATTTATGGTGGCATTTTAAATCTGTCAGAGATAACGACA
GAGACGTCTTTCTCACAAATCAAAGAGATTATTGTCCACCCAAATTATAAAATCTCAGAA
GGCAGTCATGACATTGCCTTAATAAAACTTGAGGCTCCTTTGAATTTTACTGATTTGCAA
AAAGCAATATGCCTACCTTCCAAAGATGATACAAAACCAGTTTACACTGACTGTTGGATA
ACTGGATGGGGCTTCACAGAGGAAAAAGGTAAAATCCAAAATACCCTACAAAAGGCAAAT
ATTCCTTTGATATCAAATGAAGAATGCCAAAAAAGTTACAGAGATTATAAAATAACCAAA
CAGATGATCTGTGCTGGCTATAAAGAAGGAGGAAAAGATGCCTGCAAGGGTGATTCAGGC
GGTCCCTTGGTTTGTCAACATGAAGAAACATGGCATTTGGTGGGCATCACTAGTTGGGGT
GAAGGCTGTGCCCGCAGGGAACAACCAGGAGTCTACACCAAAGTTGCTGAGTACGTGGAC
TGGATTTTAGAGAAAACCCAGGACAGCCATGGTCAGCCTTTGAGGAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 636 |
| Molecular Weight
| 70994.0 |
| Theoretical pI
| 8.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Plasma kallikrein
MIALRQAAYFICLFATVSCGCLTQLYHNIFFRGGDVSAMYTPDAQYCQLMCTFHPRCLLF
SFLPENSTSDADKRFGCFLKDSVTGTLPRVSRTGAISGHSLKRCGHQISACHRSIYKGID
MRGVNFNASKVRSAKECQERCTNNIHCQFFTYATKTFFSAEYRNTCLLKRSPQGTPTRIK
VLSDVESGFSLKACGNSKIGCRVDIFQHSAFSDVDVAGIIAPDAFVCRTICTYHPSCLFF
TFYTNAWKTDSQRNVCFLKTSQSGSPSSPTPQENAISGYSLLTCKQTLPGTEPCHSKIYP
QVAFEGEELHVTFVKGVDGCQETCTKMIRCQFFTYSLFPEDCRGEKCKCSLRLSLDGSPT
NITYGTQASSGYSLRLCKRGDSRVCTTKRTRIVGGTNASWGEWPWQVSLQVKQRAQSHLC
GGSIIGRQWVLTAAHCFDGLLLSNIWRIYGGILNLSEITTETSFSQIKEIIVHPNYKISE
GSHDIALIKLEAPLNFTDLQKAICLPSKDDTKPVYTDCWITGWGFTEEKGKIQNTLQKAN
IPLISNEECQKSYRDYKITKQMICAGYKEGGKDACKGDSGGPLVCQHEETWHLVGITSWG
EGCARREQPGVYTKVAEYVDWILEKTQDSHGQPLRK
|
| External Links |
|---|
| GenBank ID Protein
| AAI05499.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ63 |
| UniProtKB/Swiss-Prot Entry Name
| KLKB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105498 |
| GeneCard ID
| KLKB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
