| Identification |
|---|
| BMDB Protein ID
| BMDBP01296 |
| Secondary Accession Numbers
| None |
| Name
| Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| GCNT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in beta-1,3-galactosyl-O-glycosyl-glycoprotein |
| Specific Function
| Glycosyltransferase that catalyzes the transfer of an N-acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| GCNT1 |
| Gene Sequence
|
>1284 bp
ATGCTGAGGAAGTTGTGGAGGAGGAAACTTTTTTCTTTTCCCACTAAATACTACTTCTTA
TTTCTTGCTTTTTCGGTGGTCACATTCACTGTTTTAAGAATTCATCAAAAGACTGAATTT
GTAAATTTTGGACATTTGGAGCTGTTTGAAGAGAATCCTAGTAGTAATATTAATTGCACC
AAAATTCTACAGGGTGATGTAGATGAAATCCAAAAGGTAAAGCTTGAGAGTCTAACAGTG
AAATTTAAAAAGCGCGCTCGATGGACAAACTATGACTACATAAACATGACTGGTGATTGT
GCTTCTTTCATTAAGAAGCGCAAATATATTACAGAACCACTTAGTAAAGAAGAGGCGGGA
TTTCCAATAGCATATTCTATAGTGGTTCATCACAAAATTGAAATGCTTGACAGGCTCCTG
AGGGCCATCTATATGCCTCAGAATTTCTATTGTATTCACGTGGATGCAAAATCAGAGAAA
TCCTTTTTGGCTGCAGCTGTTGGCATCGCATCCTGCTTCAGTAATGTCTTTGTCGCCAGT
CAGCTGGAGAGCGTGGTGTATGCGTCCTGGAGCCGGGTTCAGGCTGACCTTAACTGCATG
CAGGACCTCTACCAGATGAATGCAGGCTGGAAGTACCTGATAAACCTCTGCGGTATGGAT
TTTCCTATTAAAACCAACCTGGAAATTGTCAGGAAGCTCAAGCTATTGATGGGCGAGAAC
AACCTAGAAACAGAGAAAATGCCATCCCATAAGAAAGAAAGGTGGAAAAAGCATTATGAA
GTCGTGAATGGAAAGCTGACAAACATGGGGACTGACAAAATACATCCACCTCTTGAAACA
CCTCTGTTTTCAGGCAGTGCTCATTTTGTGGTCAGTAGGGAATATGTGGAGTACGTGCTC
CAGAACCAAAATATACAAAAGTTTATGGAGTGGGCAAAAGACACATACAGCCCAGACGAG
TATCTCTGGGCCACTATTCAGAGGATCCCCGAAGTCCCAGGGTCATTGTCCTTAAGCTAT
AAGTATGACACGTCCGACATGCAAGCGATTGCCAGGTTTGTTAAATGGCAGTACTTTGAA
GGAGACGTTTCCAAGGGCGCCCCCTACCCGCCGTGCAGCGTCCACGTTCGCTCTGTGTGC
GTTTTCGGAGCTGGTGACTTGAACTGGCTGTTGCACGTGCACCACTTGTTTGCCAACAAA
TTCGACACGGACATTGACCTCTTTGCCATCCAGTGTTTGGACGAGCATCTAAGGCATAAA
GCCCTGGAGACGTTAAAACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 427 |
| Molecular Weight
| 49734.0 |
| Theoretical pI
| 8.57 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
MLRKLWRRKLFSFPTKYYFLFLAFSVVTFTVLRIHQKTEFVNFGHLELFEENPSSNINCT
KILQGDVDEIQKVKLESLTVKFKKRARWTNYDYINMTGDCASFIKKRKYITEPLSKEEAG
FPIAYSIVVHHKIEMLDRLLRAIYMPQNFYCIHVDAKSEKSFLAAAVGIASCFSNVFVAS
QLESVVYASWSRVQADLNCMQDLYQMNAGWKYLINLCGMDFPIKTNLEIVRKLKLLMGEN
NLETEKMPSHKKERWKKHYEVVNGKLTNMGTDKIHPPLETPLFSGSAHFVVSREYVEYVL
QNQNIQKFMEWAKDTYSPDEYLWATIQRIPEVPGSLSLSYKYDTSDMQAIARFVKWQYFE
GDVSKGAPYPPCSVHVRSVCVFGAGDLNWLLHVHHLFANKFDTDIDLFAIQCLDEHLRHK
ALETLKP
|
| External Links |
|---|
| GenBank ID Protein
| AAA83244.1 |
| UniProtKB/Swiss-Prot ID
| Q92180 |
| UniProtKB/Swiss-Prot Entry Name
| GCNT1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U41320 |
| GeneCard ID
| GCNT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
