| Identification |
|---|
| BMDB Protein ID
| BMDBP01298 |
| Secondary Accession Numbers
| None |
| Name
| Beta-1,4-glucuronyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| B4GAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acetyllactosaminide beta-1,3-N-acetylgluc |
| Specific Function
| Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose-beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O-mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Required for axon guidance; via its function in O-mannosylation of alpha-dystroglycan (DAG1). |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| B4GAT1 |
| Gene Sequence
|
>1248 bp
ATGCAGATGTCCTACGCCATCCGATGTGCCTTCTACCAGCTGCTGCTGGCCGCGCTCATG
CTGGTGGCTATGCTGCAGCTGCTCTACCTGTCGCTGCTGTCCGGGCTGCATGGGCAAGAA
GAGCAAGACCAATATTTCGAGTTCTTTCCCCCATCCCCGCGGTCGGTGGACCAAGTCAAG
GCGCAGCTCCGCACCGCGCTGGCCTCCGGAGGCGTCCTGGACGCCAGCGGCGACTACCGC
GTCTACAGGGGCCTACTGAAGACCACCATGGACCCCAACGATGTGATCCTGGCCACTCAC
GCCAGTGTGGACAACCTGCTGCACCTGTCGGGCCTGTTGGAGCGCTGGGAGGGCCCTCTG
TCGGTGTCGGTGTTCGCCGCCACCAAGGAGGAGGCGCAGCTGGCCACGGTGCTGACCTAC
GCGCTGAGCAGCCACTGCCCCGATATGCGTGCCAGGGTCGCCATGCACCTTGTGTGCCCC
TCACGCTACGAGGCCGCCGTTCCCGACCCCCGGGAGCCAGGGGAGTTTGCCCCGTTGCGT
TCCTGCCAGGAGGTCTTTGACAAGCTGGCTAGGGTGGCCCAGCCCGGGGTCAATTACGCG
CTGGGCACCAACGTCTCCTACCCCAATAACCTGCTGAGGAATCTGGCTCGTGAGGGGGCC
AACTATGCCCTGGTAATCGACGTGGACATGGTGCCCAGCGAGGGGCTGTGGAGAAGCCTG
CGGGAAATGCTGGATCAGAGCAAGCAGTGGGCGGGCACAGCGCTGGTGGTGCCTGCCTTT
GAGATCCGTCGAGCTCGCCGCATGCCCATGAACAAAAACGAGCTGCTGCAGCTCTACCAG
GTGGGCGAGGTGCGGCCCTTCTATTATGGGCTCTGCACCCCCTGCCAGGCGCCCACCAAC
TACTCCCGCTGGGTCAACCTGCCAGAAGAGACCTTGCTGAGGCCTGCCTACGTGGTGCCC
TGGCAAGACCCCTGGGAGCCATTCTACGTGGCTGGAGGCAAGGTGCCCACCTTCGACGAG
CGCTTTCGGCAGTATGGCTTCAATCGTATCAGCCAGGCCTGTGAGCTGCACGTGGCAGGA
TTCGATTTCGAGGTGCTGAATGAAGGTTTCCTGGTTCATAAAGGCTTCAAAGAAGTTTTG
AAATTCCATCCCCAAAAGGAGGCTGAAAATCAGCACAATAAGATCCTTTACCGTCAGTTC
AAACAGGAGTTGAAGGCCAAGTACCCTGACTCCCCGCGTCACTGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 415 |
| Molecular Weight
| 47231.0 |
| Theoretical pI
| 7.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
MQMSYAIRCAFYQLLLAALMLVAMLQLLYLSLLSGLHGQEEQDQYFEFFPPSPRSVDQVK
AQLRTALASGGVLDASGDYRVYRGLLKTTMDPNDVILATHASVDNLLHLSGLLERWEGPL
SVSVFAATKEEAQLATVLTYALSSHCPDMRARVAMHLVCPSRYEAAVPDPREPGEFALLR
SCQEVFDKLARVAQPGVNYALGTNVSYPNNLLRNLAREGANYALVIDVDMVPSEGLWRSL
REMLDQSKQWAGTALVVPAFEIRRARRMPMNKNELLQLYQVGEVRPFYYGLCTPCQAPTN
YSRWVNLPEETLLRPAYVVPWQDPWEPFYVAGGKVPTFDERFRQYGFNRISQACELHVAG
FDFEVLNEGFLVHKGFKEVLKFHPQKEAENQHNKILYRQFKQELKAKYPDSPRHC
|
| External Links |
|---|
| GenBank ID Protein
| AAX08785.1 |
| UniProtKB/Swiss-Prot ID
| Q5EA01 |
| UniProtKB/Swiss-Prot Entry Name
| B4GA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020768 |
| GeneCard ID
| B4GAT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
