1.0 2018-05-07 22:26:22 UTC 2020-05-20 21:04:18 UTC BMDBP01305 Enzyme DNASE1 Involved in actin binding Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:4976790, PubMed:5166750, PubMed:3352748, PubMed:2395459). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (PubMed:2395459). Binds specifically to G-actin and blocks actin polymerization (PubMed:2395459). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). BMDB0000464 Calcium BMDB0000547 Magnesium 25 >849 bp ATGAGGGGCACCAGGCTGATGGGGCTGCTGCTCGCCCTCGCTGGTCTGCTGCAGCTGGGC TTGTCCCTGAAGATAGCAGCCTTCAACATCCGCACCTTTGGGGAGACCAAGATGTCCAAT GCTACGCTCGCCAGCTACATTGTTCGGATCGTGCGTCGTTACGACATCGTCCTCATCCAG GAGGTCAGAGACAGCCACCTGGTGGCTGTGGGGAAGCTCCTGGACTATCTCAACCAGGAT GACCCAAACACCTACCACTATGTGGTCAGTGAGCCGCTGGGCCGCAACAGCTACAAGGAG CGCTACCTCTTTCTGTTCAGACCCAACAAGGTGTCCGTGCTGGACACCTACCAGTACGAC GACGGCTGCGAGTCCTGCGGGAACGACAGCTTCAGCCGGGAGCCCGCTGTGGTCAAGTTC TCATCCCACTCCACCAAGGTCAAGGAATTTGCCATTGTTGCCCTGCACTCGGCCCCATCG GACGCAGTGGCTGAGATTAATTCTCTCTACGATGTCTACCTGGATGTCCAGCAGAAGTGG CACTTGAACGATGTCATGTTGATGGGCGATTTCAATGCTGACTGCAGCTACGTGACCTCC TCGCAGTGGTCATCCATCCGCCTGCGTACGAGCTCCACCTTCCAGTGGCTGATTCCTGAC AGTGCCGACACCACGGCTACGTCCACGAACTGCGCCTATGACAGGATCGTGGTCGCAGGG TCTCTGCTCCAGAGTTCTGTGGTTCCTGGCTCGGCCGCTCCCTTTGACTTCCAAGCTGCA TACGGACTGAGCAATGAGATGGCCCTGGCCATCAGTGACCATTACCCGGTGGAGGTGACG CTGACATAA 282 31346.0 5.31 1-22 >Deoxyribonuclease-1 MRGTRLMGLLLALAGLLQLGLSLKIAAFNIRTFGETKMSNATLASYIVRIVRRYDIVLIQ EVRDSHLVAVGKLLDYLNQDDPNTYHYVVSEPLGRNSYKERYLFLFRPNKVSVLDTYQYD DGCESCGNDSFSREPAVVKFSSHSTKVKEFAIVALHSAPSDAVAEINSLYDVYLDVQQKW HLNDVMLMGDFNADCSYVTSSQWSSIRLRTSSTFQWLIPDSADTTATSTNCAYDRIVVAG SLLQSSVVPGSAAPFDFQAAYGLSNEMALAISDHYPVEVTLT CAA04819.1 P00639 DNAS1_BOVIN 1ATN 1DNK 2A3Z 2A40 2A41 2A42 2D1K 2DNJ 3CJC 3DNI 3W3D 1ATN 2A40 2A41 AJ001538 DNASE1