<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:26:22 UTC</creation_date>
  <update_date>2020-05-20 21:05:02 UTC</update_date>
  <accession>BMDBP01306</accession>
  <secondary_accessions>
    <accession>BMDBP03175</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>F7</gene_name>
  <general_function>Involved in calcium ion binding</general_function>
  <specific_function>Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000464</accession>
      <name>Calcium</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>12</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1344 bp
ATGCTGTCCCAGGCCTGGGCTCTGGCCCTCCTCTGCTTTCTGCTCAGCCTGTGGGGGTCC
CTGCCGGCAGTCTTCCTGCCCCAGGAGCAGGCCCTCAGCATCCTGCATCGGCCTCGGCGT
GCCAACGGGTTCCTGGAGGAGCTGCTGCCGGGCTCGCTGGAGCGGGAGTGCAGGGAGGAG
CTCTGCTCCTTCGAGGAAGCCCACGAGATCTTCCGCAACGAGGAGAGGACGAGGCAGTTC
TGGGTTTCCTACAATGACGGGGACCAGTGCGCCTCCAGCCCCTGCCAGAACGGGGGCTCC
TGTGAGGACCAGCTCCGGTCCTACATCTGCTTCTGCCCCGACGGCTTCGAGGGCCGGAAC
TGTGAGACCGACAAGCAGAGCCAGCTGATCTGCGCCAACGACAATGGCGGCTGTGAGCAG
TACTGTGGGGCTGACCCGGGGGCCGGGCGCTTCTGCTGGTGCCATGAGGGCTACGCGCTC
CAGGCAGACGGGGTGTCCTGCGCACCCACAGTGGAATATCCGTGCGGGAAAATACCTGTT
CTGGAAAAAAGAAATGGCAGCAAGCCCCAAGGGCGAATTGTGGGGGGCCACGTCTGCCCC
AAAGGGGAATGCCCCTGGCAGGCCATGCTGAAGCTGAACGGGGCGCTGCTGTGCGGGGGC
ACCCTGGTCGGCCCGGCCTGGGTGGTCTCCGCCGCCCACTGCTTCGAAAGGCTCCGGAGC
AGGGGGAACCTGACGGCTGTGCTGGGCGAGCACGACCTCAGCCGCGTGGAGGGCCCAGAG
CAGGAGCGGCGGGTGGCGCAGATCATTGTCCCCAAGCAGTACGTGCCGGGCCAGACGGAC
CACGACGTGGCCCTGCTGCAGCTGGCCCAGCCCGTGGCCCTGGGCGACCACGTGGCACCC
CTCTGTCTGCCCGACCCGGACTTCGCGGACCAGACGCTGGCCTTCGTGCGCTTCTCGGCC
GTCAGCGGCTGGGGCCAGCTCCTGGAGCGCGGGGTCACCGCCCGCAAGCTCATGGTGGTG
CTGGTGCCCCGGCTGCTAACCCAGGACTGCCTGCAGCAGTCGCGCCAGAGGCCCGGCGGG
CCTGTGGTCACGGACAACATGTTCTGCGCTGGCTATAGCGACGGCAGCAAGGATGCCTGC
AAGGGGGACAGTGGGGGCCCGCACGCCACACGCTTCCGGGGCACCTGGTTCCTGACCGGC
GTCGTCAGCTGGGGCGAGGGCTGCGCGGCAGCCGGCCACTTTGGGATCTACACGCGGGTC
TCCCGCTACACGGCCTGGCTGCGGCAGCTGATGGGCCACCCGCCGTCCAGGCAGGGCTTC
TTCCAGGTCCCGCTGCTGCCCTAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>447</residue_number>
    <molecular_weight>48961.0</molecular_weight>
    <theoretical_pi>6.42</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>1-23</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Coagulation factor VII
MLSQAWALALLCFLLSLWGSLPAVFLPQEQALSILHRPRRANGFLEELLPGSLERECREE
LCSFEEAHEIFRNEERTRQFWVSYNDGDQCASSPCQNGGSCEDQLRSYICFCPDGFEGRN
CETDKQSQLICANDNGGCEQYCGADPGAGRFCWCHEGYALQADGVSCAPTVEYPCGKIPV
LEKRNGSKPQGRIVGGHVCPKGECPWQAMLKLNGALLCGGTLVGPAWVVSAAHCFERLRS
RGNLTAVLGEHDLSRVEGPEQERRVAQIIVPKQYVPGQTDHDVALLQLAQPVALGDHVAP
LCLPDPDFADQTLAFVRFSAVSGWGQLLERGVTARKLMVVLVPRLLTQDCLQQSRQRPGG
PVVTDNMFCAGYSDGSKDACKGDSGGPHATRFRGTWFLTGVVSWGEGCAAAGHFGIYTRV
SRYTAWLRQLMGHPPSRQGFFQVPLLP</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAX46431.1</genbank_protein_id>
  <uniprot_id>P22457</uniprot_id>
  <uniprot_name>FA7_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BT021584</genbank_gene_id>
  <genecard_id>F7</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
