| Identification |
|---|
| BMDB Protein ID
| BMDBP01319 |
| Secondary Accession Numbers
| None |
| Name
| Hepatocyte growth factor-regulated tyrosine kinase substrate |
| Synonyms
|
Not Available
|
| Gene Name
| HGS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| HGS |
| Gene Sequence
|
>2334 bp
ATGGGGCGTGGCAGTGGCACCTTCGAGCGTCTCCTAGACAAAGCGACCAGCCAGCTTCTT
CTGGAGACTGACTGGGAGTCCATCCTCCAGATCTGTGACCTGATCCGCCAGGGGGACACG
CAGGCAAAATATGCAGTGAGTTCCATCAAGAAGAAAGTTAATGATAAGAATCCCCACGTG
GCCTTGTACGCCCTAGAGGTCATGGAGTCTGTGGTGAAGAATTGCGGCCAGACAGTCCAT
GATGAGGTGGCAAACAAGCAGACCATGGAGGAGCTGAAGGATCTGCTGAAGAGGCAGGTG
GAAGTAAACGTCCGGAACAAGATCCTGTATCTGATTCAGGCCTGGGCACACGCCTTCCGG
AACGAGCCCAAGTACAAGGTGGTCCAGGACACGTACCAGATCATGAAGGTGGAAGGACAC
GTCTTCCCAGAGTTCAAGGAAAGCGATGCCATGTTTGCTGCGGAGAGAGCCCCTGACTGG
GTGGATGCTGAGGAGTGCCACCGGTGCCGGGTGCAGTTTGGGGTCATGACCCGCAAGCAC
CACTGCCGGGCGTGTGGCCAGATCTTCTGCGGCAAGTGCTCTTCCAAGTACTCCACCATC
CCCAAGTTCGGCATTGAGAAGGAGGTGCGGGTGTGTGAGCCCTGCTTTGAGCAGCTCAAC
AAGAAAGCGGAGGGAAAAGCGGCCTCGACGACGGAGCTGCCCCCGGAGTACCTGACCAGC
CCGCTGTCTCAGCAGTCGCAGCTGCCCCCTAAAAGGGATGAGACAGCCCTGCAGGAAGAG
GAGGAGCTGCAGCTGGCCCTGGCCCTGTCTCAGTCGGAGGCCGAGGAGAAGGAACGGATG
AGGCAGAAGTCGGCCTATACCGCGTACCCCAAGGCGGAACCCACGCCCGTGGCCTCCTCA
GCACCCCCCGCCAGCAGCCTGTATTCTTCGCCTGTGAACTCGTCGGCGCCTCTGGCTGAG
GACATCGATCCTGAGCTTGCGCGGTACCTGAACCGGAACTACTGGGAGAAGAAGCAGGAG
GAGGCTCGGAAGAGCCCCACGCCGTCCGCGCCGGTGCCTCTGACAGAGCCCACGGCCCAG
CCTGGGGAGGGACACGCAATCCCTGCCAACGTGGAGACTTCCCTCCCAGAGACAGACCCT
CAGGCCGTAACTGCAGCCGGAGCTGCCTTTAGTGAGCAGTACCAGAATGGGGAGTCCGAG
GAGAGCCACGCACAGTTCCTGAAGGCCCTCCAGAATGCCGTCACCACCTTCGTCAACCGC
ATGAAGAGCAACCACGTGCGGGGCCGCAGCATCACCAACGACTCGGCCGTGCTGTCCCTC
TTCCAGTCCATCAACACCATGCACCCCCAGCTGCTGGAGCTGCTCAACCAGCTGGATGAG
CGCAGGTTATACTACGAGGGACTGCAGGACAAGCTGGCACAGATCCGTGATGCCCGGGGG
GCACTCAGCGCCCTGCGGGAGGAGCACCGGGAGAAGCTTCGCCGCGCAGCTGAGGAGGCT
GAGCGCCAGCGCCAGATCCAGCTGGCCCAGAAGCTGGAGATCATGCGGCAGAAGAAGCAG
GAGTACTTAGAGGTGCAGCGGCAGCTGGCCATCCAGCGCCTGCAGGAGCAGGAGAAGGAG
CGGCAAATGCGCCTGGAGCAGCAGAAGCAGACCATCCAGATGCGGGCCCAGATGCCCGCT
TTCTCCCTGCCCTACGCCCAGCTCCAGGCCATGCCTGCAGCAGGGGGCGTGCTGTACCAG
CCTTCCGGCCCGGCGAGCTTCGCGGGCACCTTCAGCCCGGCCGGCTCGGTGGAGGGCTCG
CCCATGCACACCATGTACATGAGTCAGCCGGCCCCGGCTGCCAGCGGCCCCTACCCCAGC
ATGCCAGCAGCCGCAGCAGACCCCAGCATGGTGAGCGCTTACATGTACCCAGCAGGGGCG
GCTGGTGCACAGGCAGCCGCACAGGGCCCCGCAGGGCCCACCACCAGCCCAGCCTACTCA
TCATACCAGCCTACTCCCACGCAGGGCTATCAGACCGTGGCCTCCCAGGCCCCACAGAGC
CTCCCAGCCATCTCCCAGCCCCCGCAGTCTGGTACGATGGGCTACATGGGGAGCCAGTCA
GTGTCCATGGGCTACCAGCCTTATAGCATGCAGAATCTCATGCCGACCCTCCCCGGCCAA
GACGCGCCTCTGCCGCCCCCACAGCAACCCTATATCTCAGGGCAGCAGCCCGTGTACCAG
CAGATGGCGCCCTCCAGCGGCCCTCCTCAGCAGCAGCCCCCAGTGGCCCAGCAGCCCCCA
GCACAGGGCCCGCCAGCACAGGGCAGTGAAGCCCAGCTCATCTCGTTTGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 777 |
| Molecular Weight
| 85786.0 |
| Theoretical pI
| 6.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hepatocyte growth factor-regulated tyrosine kinase substrate
MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVSSIKKKVNDKNPHV
ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCFEQLNKKAEGKAASTTELPPEYLTS
PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERMRQKSAYTAYPKAEPTPVASS
APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPTAQ
PGEGHAIPANVETSLPETDPQAVTAAGAAFSEQYQNGESEESHAQFLKALQNAVTTFVNR
MKSNHVRGRSITNDSAVLSLFQSINTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARG
ALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKE
RQMRLEQQKQTIQMRAQMPAFSLPYAQLQAMPAAGGVLYQPSGPASFAGTFSPAGSVEGS
PMHTMYMSQPAPAASGPYPSMPAAAADPSMVSAYMYPAGAAGAQAAAQGPAGPTTSPAYS
SYQPTPTQGYQTVASQAPQSLPAISQPPQSGTMGYMGSQSVSMGYQPYSMQNLMPTLPGQ
DAPLPPPQQPYISGQQPVYQQMAPSSGPPQQQPPVAQQPPAQGPPAQGSEAQLISFD
|
| External Links |
|---|
| GenBank ID Protein
| ABG66987.1 |
| UniProtKB/Swiss-Prot ID
| Q0V8S0 |
| UniProtKB/Swiss-Prot Entry Name
| HGS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT026148 |
| GeneCard ID
| HGS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
