| Identification |
|---|
| BMDB Protein ID
| BMDBP01320 |
| Secondary Accession Numbers
| None |
| Name
| Calpain-2 catalytic subunit |
| Synonyms
|
Not Available
|
| Gene Name
| CAPN2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| CAPN2 |
| Gene Sequence
|
>2103 bp
ATGGCGGGCATCGCGGCCAAGCTGGCGAAGGACCGGGAGGCGGCCGAGGGGCTGGGCTCG
CACGAGAGGGCGGTCAAGTACCTCAACCAGGACTACGCGGCGCTGCGGGACGAGTGCCTG
GAGGCCGGGGCGCTGTTCCAGGACCCCTCCTTCCCGGCCCTGCCGTCCTCCCTGGGCTTC
AAGGAGTTGGGACCTTACTCCAGCAAGACCCGGGGCATCGAGTGGAAGCGGCCCACGGAG
ATCTGCGATAATCCCCAATTTATTACTGGAGGAGCCACTCGCACAGACATCTGCCAAGGA
GCCCTAGGTGACTGCTGGCTGCTGGCCGCAATTGCCTCCCTCACTTTGAATGAAGAAATC
CTGGCTCGAGTCGTCCCCCTGGACCAGAGCTTCCAGGAGAACTATGCGGGGATCTTCCAC
TTCCAGTTCTGGCAGTACGGCGAGTGGGTGGAGGTGGTGGTGGACGACAGGCTGCCCACC
AAGGACGGGGAGCTGCTCTTCGTGCACTCGGCAGAGGGCAGCGAGTTCTGGAGTGCGCTG
CTGGAGAAGGCCTACGCCAAGATCAATGGGTGTTATGAAGCACTTTCGGGGGGCGCCACC
ACTGAGGGCTTCGAGGACTTCACTGGAGGCATCGCTGAGTGGTATGAGTTGAGGAAGGCC
CCTCCCAACCTGTTCAGGATCATCCAGAAGGCTCTGCAGAAAGGCTCTCTCCTGGGCTGC
TCCATCGATATCACCAGCGCTGCGGACTCGGAGGCCATCACGTTCCAGAAGCTGGTGAAG
GGGCACGCGTACTCGGTGACCGGTGCCGAGGAGGTGGAAAGCAGAGGAAGCCTGCAGAAG
CTGATCCGCATCCGGAATCCCTGGGGAGAGGTGGAGTGGACCGGGCAGTGGAATGACAAC
TGCCCAAACTGGAACACAGTCGACCCCGAGGTGAGGGAAACGCTGACTAGACAGCATGAG
GATGGGGAATTCTGGATGTCTTTCAACGACTTCCTGAGACACTATTCCCGCCTGGAAATC
TGCAACCTGACCCCTGACACACTCACCAGTGACAGCTACAAGAAGTGGAAACTCACCAAG
ATGGATGGGAACTGGAGGCGGGGCTCCACCGCGGGCGGCTGCAGGAACTACCCGAACACG
TTCTGGATGAATCCTCAGTACCTGATCAAGCTGGAGGAAGAGGACGAGGACCAGGAGGAC
GGGGAGAGCGGCTGCACCTTCCTGGTGGGCCTCATCCAGAAGCACCGGCGGCGGCAGAGG
AAGATGGGCGAGGACATGCACACCATTGGCTTCGGCATCTATGAGGTTCCAGAGGAGTTG
ACTGGACAGACCAACATCCACCTCAGCAAAAAATTCTTCCTGACAACCAGAGCGCGGGAG
CGGTCGGACACCTTCATCAACCTGCGGGAGGTGCTCAACCGCTTCAAGCTGCCCCCCGGG
GAGTACATCGTGGTGCCCTCCACCTTCGAGCCCAACAAGGACGGCGACTTCTGCATCCGG
GTCTTTTCCGAGAAGAAAGCCGACTACCAAGTTGTCGACGATGAAATCGAGGCCAACATT
GACGAGATTGACATCAGCGAGGATGACATCGATGATGGATTCAGGAGACTGTTCGCCCAG
CTGGCCGGAGAGGACGCAGAGATTTCTGCCTTTGAGTTGCAGACAATCCTGAGAAGAGTG
CTAGCAAAGCGCCAAGATATCAAGTCCGACGGCTTTAGCATTGAGACCTGCAAAATCATG
GTGGACATGCTCGACTCGGATGGGAGTGGCAAACTGGGTCTGAAGGAGTTCTACATTCTC
TGGACGAAGATTCAGAAATACCAAAAAATTTACCGGGAAATTGATGTGGACCGGTCTGGA
ACCATGAACTCCTATGAGATGCGGAAAGCATTAGAAGAAGCAGGTTTCAAGATGCCCTGT
CAGCTCCACCAAGTGATTGTCGCCCGGTTTGCAGATGACGACCTCATCATCGATTTTGAC
AATTTTGTCCGGTGTTTGATTCGACTGGAGACACTGTTCAGGATATTTAAGCAGCTGGAC
CCCGAGAATACTGGAATGATCCAGCTTGACCTTATCTCTTGGCTGTCTTTTTCAGTACTT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 700 |
| Molecular Weight
| 79935.0 |
| Theoretical pI
| 4.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Calpain-2 catalytic subunit
MAGIAAKLAKDREAAEGLGSHERAVKYLNQDYAALRDECLEAGALFQDPSFPALPSSLGF
KELGPYSSKTRGIEWKRPTEICDNPQFITGGATRTDICQGALGDCWLLAAIASLTLNEEI
LARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL
LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKAPPNLFRIIQKALQKGSLLGC
SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESRGSLQKLIRIRNPWGEVEWTGQWNDN
CPNWNTVDPEVRETLTRQHEDGEFWMSFNDFLRHYSRLEICNLTPDTLTSDSYKKWKLTK
MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDQEDGESGCTFLVGLIQKHRRRQR
KMGEDMHTIGFGIYEVPEELTGQTNIHLSKKFFLTTRARERSDTFINLREVLNRFKLPPG
EYIVVPSTFEPNKDGDFCIRVFSEKKADYQVVDDEIEANIDEIDISEDDIDDGFRRLFAQ
LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL
WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDDLIIDFD
NFVRCLIRLETLFRIFKQLDPENTGMIQLDLISWLSFSVL
|
| External Links |
|---|
| GenBank ID Protein
| AAI34527.1 |
| UniProtKB/Swiss-Prot ID
| Q27971 |
| UniProtKB/Swiss-Prot Entry Name
| CAN2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC134526 |
| GeneCard ID
| CAPN2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
