| Identification |
|---|
| BMDB Protein ID
| BMDBP01355 |
| Secondary Accession Numbers
| None |
| Name
| Solute carrier family 22 member 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC22A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| SLC22A1 |
| Gene Sequence
|
>1692 bp
ATGCTCACTGTAGATGATGTACTGGAGCAGGTTGGGGAGTTCGGTTGGTTCCAGAAGCAA
ACCTTCCTGATCCTGTGCCTGCTCTCGGCCGCCTTCGCCCCCATCTACGTGGGCATCGTC
TTCCTGGCCTTCACCCCGGACCACCGCTGCCGGAGCCCCGGGGTGGCGGAGCTGAGCCGG
CGATGCGGCTGGAGCCTGGCGGAGGAGCTCAACTACACGGTGCCAGGCCCGGGACCCGAG
AGCCAGTGCCTCCGCTACGAGGTGGACTGGAACCAGAGCACCCTTGGCTGCCTGGACCCG
CTGGCCAGCCTGGCTACCAACGGCAGCCCCCTGCCCCTGGGCCCCTGCGAGCAGGGCTGG
GTGTACGACACGCCCGGCTCCTCCATCGTGACCGAGTTTAACCTGGTGTGTGATGACTCT
TGGAAGGTGGACCTCTTTCAGTCCTGTGTGAACTTGGGCTTCTTCCTGGGCTCTCTGGGA
GTCGGCTACATCGCAGACAGGTTTGGCCGCAAGGTGTGCCTCTTGGCTACCACCCTCACC
TGCGCCAGCTTGGGCGTCCTGACGGCCGTGGCTCCGGACTACACGTCCCTGCTGATCTTC
CGCCTGCTGCAGGGGCTGGTCAGCAAGGGCAGCTGGACGGCTGGCTACACCCTGATCACG
GAGTTCGTGGGCCTGGGCTACAGACGGACAGTGGCGATCCTCTACCAGATGGCCTTCACC
GTGGGGCTGGTGCTGCTCTCCGGACTGGCCTACATCCTCCCGCACTGGCGCTGGCTGCAG
CTGGCCGTCTCCCTGCCCATCTTCCTGCTCCTCTTCCGCTTCTGGTTTGTGCCCGAGTCC
CCCCGATGGCTGTTATCGCAAAAGAGAAACACTGAGGCGATAAAGATCATGGACCACATT
GCGCAAAAGAACGGGAAGCTGCCTCCTGCTGACCTGAAGATGCTGTCTCTCGAGGAGGAC
GTCACTGAGAAGCTGAGCCCCTCATTCATAGACCTGTTCCGCACGCCCAACCTGAGGAAG
TACACCTTCATCCTGATGTACCTGTGGTTCACCAGCTCCGTGGTCTACCAGGGCCTCATC
ATGCACGTGGGCGCCACCGGCGGGAACCTCTACCTGGACTTCCTCTACTCCGCTCTGGTC
GAGTTCCCCGCAGGCTTCATCATCCTCGTCACCATCGACCGCTTCGGCCGCCGCTACCCG
CTGGCCACGTCCAACTTGGCGGCCGGGCTGGCCTGCTTCCTCATGATCTTTATCCCACAC
GATCTGCCCTGGTTGAATATCATGGTAGCTTGTGTTGGCAGAATGGGGATCACCATCGTG
TTCCAGATGGTGTGCCTGGTCAACGCCGAGCTGTTCCCGACCTTCATCCGGAACCTTGGC
ATGATGGTGTGTTCCTCCCTGTGTGATTTGGGTGGGGTTCTCACCCCGTTCCTGGTCTTC
AGGCTGATGGAGGTTTGGCAAGGCTCGCCGCTCATTTTGTTTGCGGCCTTGGGGCTGGTT
GCCGGGGGAATGACGCTGCTTCTTCCGGAGACCAAGGGGGTCACTTTGCCAGAGACCATC
GAGGATGCCGAGAACCTGCAGAGGAAAGCAAAACCCAAAGAAAACAAGATTTACCTTCAG
GTTCAAACATCAGAACTCAACACACAGGCAGCCGAGAGAGATGCTTCGCAGGGGACCGCG
CAGCAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 563 |
| Molecular Weight
| 62502.0 |
| Theoretical pI
| 5.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 22-42
- 145-165
- 172-192
- 197-219
- 233-253
- 258-278
- 343-363
- 372-392
- 399-418
- 424-446
- 460-480
- 488-508
|
| Protein Sequence
|
>Solute carrier family 22 member 1
MLTVDDVLEQVGEFGWFQKQTFLILCLLSAAFAPIYVGIVFLAFTPDHRCRSPGVAELSR
RCGWSLAEELNYTVPGPGPESQCLRYEVDWNQSTLGCLDPLASLATNGSPLPLGPCEQGW
VYDTPGSSIVTEFNLVCDDSWKVDLFQSCVNLGFFLGSLGVGYIADRFGRKVCLLATTLT
CASLGVLTAVAPDYTSLLIFRLLQGLVSKGSWTAGYTLITEFVGLGYRRTVAILYQMAFT
VGLVLLSGLAYILPHWRWLQLAVSLPIFLLLFRFWFVPESPRWLLSQKRNTEAIKIMDHI
AQKNGKLPPADLKMLSLEEDVTEKLSPSFIDLFRTPNLRKYTFILMYLWFTSSVVYQGLI
MHVGATGGNLYLDFLYSALVEFPAGFIILVTIDRFGRRYPLATSNLAAGLACFLMIFIPH
DLPWLNIMVACVGRMGITIVFQMVCLVNAELFPTFIRNLGMMVCSSLCDLGGVLTPFLVF
RLMEVWQGSPLILFAALGLVAGGMTLLLPETKGVTLPETIEDAENLQRKAKPKENKIYLQ
VQTSELNTQAAERDASQGTAQQK
|
| External Links |
|---|
| GenBank ID Protein
| AAI51506.1 |
| UniProtKB/Swiss-Prot ID
| A7MBE0 |
| UniProtKB/Swiss-Prot Entry Name
| S22A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151505 |
| GeneCard ID
| SLC22A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
