| Identification |
|---|
| BMDB Protein ID
| BMDBP01615 |
| Secondary Accession Numbers
| None |
| Name
| TIR domain-containing adapter molecule 1 |
| Synonyms
|
Not Available
|
| Gene Name
| TICAM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens (By similarity). Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| TICAM1 |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 759 |
| Molecular Weight
| 82359.0 |
| Theoretical pI
| 6.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 30-56
- 77-98
- 113-133
- 140-158
- 178-200
- 229-246
- 288-307
- 319-338
- 350-372
|
| Protein Sequence
|
>TIR domain-containing adapter molecule 1
MACTGPSLSGAFDILGAAGQDKLLYLKHKLKTLRPGCRGAYLLHAMVLLKLGQETEARIS
LEALKADAVAQLVARQWAGVDSTETPEEPPDLSWAVARVYHLLTEEKLCPATMREEAYRA
ALRAFRSRDDLQLGELQEEARDRCGWDVLGDLGGVQTLRSDLGCLPPSSASLSRTRSDPR
PIEHLSGWSTACSLRSTGSPASLGSNLEISQSPTMALLSVHHSHHGPSKLCDHPQASVVP
EPAPMGCQEPEEMSWPPSVEAADSPVRPSSPGPGLPEVTTDACPASPHDPPEVPEISAHY
PVECTDVPAAPKSLPSPSKNTCLVTDQTPVQLSEEDTAYLSAQPRPPTPSVPQTSPSFPS
ASTSPFPSPSTPPEAHPTPSKAHPTPPKAHSTPPKAHPTSPKAHPTSPKAHPTVWNPEPP
PPELESSEQKFYNFVVLHASADEHIALRVRERLEALGVHDGATFCEDFQVPGRGELHCLQ
DALDHSAFIILLLTSNFDCRLSQHQTNQSLMSSLTRHGWQDCVIPFLPLESSLAQLSPST
SSLLTGLVLLDEHSKIFARKVTNTFKPQMLRARKAKWRKEQDARALREQSQQLESERQHA
AAWGAAYSAYVHSYLAYQTQVEKLQVALANYMPFGTQLPFGGQGSLGTPPSSFPTLPGHQ
PPPLPPWLGGTPPPIFPQPPQTFPQPPPTFPQPPPTFQQPPPACPQPLDFSQAPPARPQS
PGLQPLIIHHAQMVQLGVNNHMWNQRGTQAPEDNTRETE
|
| External Links |
|---|
| GenBank ID Protein
| CAI53671.1 |
| UniProtKB/Swiss-Prot ID
| Q4JF29 |
| UniProtKB/Swiss-Prot Entry Name
| TCAM1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ879588 |
| GeneCard ID
| TICAM1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
