<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:27:49 UTC</creation_date>
  <update_date>2020-05-20 21:09:00 UTC</update_date>
  <accession>BMDBP01622</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>SELENOK</gene_name>
  <general_function>Involved in selenium binding</general_function>
  <specific_function>Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001349</accession>
      <name>Selenium</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0003288</accession>
      <name>Selenocysteine</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>22</chromosome_location>
    <locus/>
    <gene_sequence>&gt;279 bp
ATGGTTTACATCTCGAATGGACAAGTGTTGGACAGCAGGAGTCAGTCCCCATGGAGATTA
TCTTTTATAACAGATTTCTTCTGGGGAATAGCTGAGTTTGTGGTTTTGTTTTTCAGAACT
CTGCTTCAACAAGATGTGAAAAAGAGAAGAGGCTACGGAAGCTCATCTGATTCCAGATAT
GATGACGGAAGAGGGCCACCAGGAAACCCCCCCAGAAGAAGAATGGGTCGAATTAATCAT
CTGCAGGGCCCTAATCCTCCTCCAATGGCCGGTGGATGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>95</residue_number>
    <molecular_weight>10805.0</molecular_weight>
    <theoretical_pi>11.61</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>20-42</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Selenoprotein K
MVYISNGQVLDSRSQSPWRLSFITDFFWGIAEFVVLFFRTLLQQDVKKRRGYGSSSDSRY
DDGRGPPGNPPRRRMGRINHLQGPNPPPMAGGUGR</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI08151.1</genbank_protein_id>
  <uniprot_id>Q32PE3</uniprot_id>
  <uniprot_name>SELK_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC108150</genbank_gene_id>
  <genecard_id>SELENOK</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
