| Identification |
|---|
| BMDB Protein ID
| BMDBP01764 |
| Secondary Accession Numbers
| None |
| Name
| Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| CMTR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in methyltransferase activity |
| Specific Function
| S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| CMTR1 |
| Gene Sequence
|
>2508 bp
ATGAAGAGGAGAAATGATTCAGAATGCACTGCCCCTCTCAAGAAACAGAAGAAAAGAGTT
GCTGAGCTTGCCCTGAGCCTCAGCTCCACATCTGATGATGAGCCTCCTTCCTCTGTCAAT
CATGCAGCAAAAGCATCTGCTACCAGCCTTAGTGGGTCTGACAGCGAGACTGAGGGGAAG
CAACGCAGCTCGGACTCTTTCGACGATGCATTCAAAGCAGACTCTCTTGTGGAGGGAACT
TCCTCCCGCTACTCCATGTATAACAGTGTGTCCCAGAAGCTCATGGCCAAGATGGGCTTC
AAGGAAGGTGAAGGATTGGGTAAATACAGCCAGGGTCGGAAGGACATCGTTGAGGCCTCT
AATCAGAAAGGTCGACGAGGCTTGGGTCTGACACTGCAAGGCTTTGACCAAGAGCTGAAT
GTGAACTGGCGAGATGAGCCAGAGCCCAGTGCCTGTGAGCAGGTGTCATGGTTCCCAGAA
TGTACCACTGAAATTCCTGACACTCAGGAAATGAGCGATTGGATGGTTGTGGGGAAGAGA
AAGATGATTATTGAAGATGAAACAGAGTTTTGTGGGGAAGGCCTGCTTCGCAGTGTGTTG
AAGTGTAAGAGTGTGTTTGATGTTCTGGATGGGGAGGAGATGCGGCGAGCTCGGACCCGG
GCCAATCCCTACGAGATGATCCGAGGAGTCTTCTTCCTCAACAGGGCAGCAATGAAGATG
GCTAACATGGATTTTGTGTTCGATCGCATGTTTACAAATCCAAGGGACTCTTATGGGAAG
CCGCTGGTGAAGGACCGGGAAGCGGAGCTTCTGTACTTTGCCGACGTCTGTGCGGGCCCG
GGCGGCTTCTCGGAGTACGTGCTGTGGAGGAAGAGGTGGCACGCCAAGGGCTTCGGGCTG
ACTCTGAAGGGCCCTCACGACTTCAAGCTGGAGGACTTCTACTCCGCTTCCAGCGAGCTC
TTCGAGCCCTACTACGGTGAGGGTGGGATCGATGGAGACGGAGACATCACCCGCCCGGAG
AACATCAATGCTTTTAGGAATTTCGTCCTGGATAACACCGATCACAAGGGCGTCCACTTT
CTGATGGCTGATGGGGGTTTCTCAGTGGAGGGACAGGAGAACCTGCAGGAGATCCTCAGC
AAACAGCTGCTGCTCTGTCAGTTCCTCATGGCGCTGTCTGTTGTCCGGACAGGAGGCCAC
TTTATCTGTAAAACCTTTGACCTCTTCACACCGTTCAGCGTGGGGCTCATCTACCTGCTG
TACTGCTGCTTTGAACGAGTCTGTCTCTTTAAGCCGATTACCAGCCGTCCTGCCAACTCA
GAGAGGTATGTGGTGTGCAAGGGCCTGAAGGTGGGCATAGACGAAGTGCGGGATTACCTC
TTCTCAGTCAACATTAAACTCAACCAGCTGCGGAACACTGATTCTGACGTCAACCTTGTG
GTCCCCTTGGAGGTGATCAAGGGAGACCATGAATTTACTGACTACATGATACGGTCCAAC
GAGGGCCACTGTAGTCTGCAGATCAAAGCTCTGGCCAAAATCCGTGCCTTTGTCCAAGAC
ACGACCCTGATCGAGCCTCGGCAGGCAGAGATCCGGAAAGAGTGCCTCCGGCTCTGGGGG
ATCCCGGACCAGGCTCGAGTTGCTCCTTCTTCCACAGACCCAAAATCTAAGTTCTTCGAG
CTCATCCAGGGCACTGAGATTGACATCTTCAGCTACAAGCCCACGCCGCTTACTGCCAAG
ACCCTGGAGAAGATCCGCCCAGTGCTCGACTACCGCTGCATGGTGTCTGGCAGCGAGCAG
AAGTTCCTCATCGGCCTGGGGAAGTCTCAGATCTACACGTGGGATGGCCGCCAGTCAGAC
CGCTGGGTCAAGCTGGACCTGAAGACGGAGCTGCCGCGGGATACTCTGCTCTCTGTGGAG
ATTGTCCACGAGCTGAAAGGGGAGGGGAAGGCCCAGCGGAAGATAAGTGCGATCCACATC
CTCGATGTCCTCGTGCTGAACGGCAGCGACGTGCGGGAGCAGCACTTCAACCAACGGATT
CAGCTTGCTGAGAAATTTGTGAAAGCTGTTTCCAAGCCCAGTCGGCCTGACATGAATCCC
ATCAGGGTGAAGGAGGTGTACCGGCTGGAGGAGATGGAGAAGATTTTTGTTAGGCTAGAA
ATGAAGATCATTAAGGGCTCCAGTGGCACACCGAAGCTCAGCTACACAGGGCGGGACGAC
CGGCACTTCGTGCCCACCGGCCTCTACATCGTCAGGACGGTGAATGAGCCATGGACGATG
GGATTCAGCAAAAGCTTCAAGAGGAAGTTCTTCTATAACAAGAAAACCAAGAACTCTACC
TTTGACCTCCCTGCAGATGCCATTGCTCCATTTCACATCTGCTACTATGGCCGGCTCTTC
TGGGAGTGGGGGGATGGCATCCGTGTGCACGAATCCCAGAAGCCCCAGGACCCAGACAAG
CTGTCCAAGGAGGACGTCCTCTCCTTCATCCAGACGCACAGCGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 835 |
| Molecular Weight
| 95142.0 |
| Theoretical pI
| 7.62 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>FTSJD2 protein
MKRRNDSECTAPLKKQKKRVAELALSLSSTSDDEPPSSVNHAAKASATSLSGSDSETEGK
QRSSDSFDDAFKADSLVEGTSSRYSMYNSVSQKLMAKMGFKEGEGLGKYSQGRKDIVEAS
NQKGRRGLGLTLQGFDQELNVNWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR
KMIIEDETEFCGEGLLRSVLKCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKRWHAKGFGL
TLKGPHDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENINAFRNFVLDNTDHKGVHF
LMADGGFSVEGQENLQEILSKQLLLCQFLMALSVVRTGGHFICKTFDLFTPFSVGLIYLL
YCCFERVCLFKPITSRPANSERYVVCKGLKVGIDEVRDYLFSVNIKLNQLRNTDSDVNLV
VPLEVIKGDHEFTDYMIRSNEGHCSLQIKALAKIRAFVQDTTLIEPRQAEIRKECLRLWG
IPDQARVAPSSTDPKSKFFELIQGTEIDIFSYKPTPLTAKTLEKIRPVLDYRCMVSGSEQ
KFLIGLGKSQIYTWDGRQSDRWVKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHI
LDVLVLNGSDVREQHFNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLE
MKIIKGSSGTPKLSYTGRDDRHFVPTGLYIVRTVNEPWTMGFSKSFKRKFFYNKKTKNST
FDLPADAIAPFHICYYGRLFWEWGDGIRVHESQKPQDPDKLSKEDVLSFIQTHSA
|
| External Links |
|---|
| GenBank ID Protein
| AAI33560.1 |
| UniProtKB/Swiss-Prot ID
| A2VE39 |
| UniProtKB/Swiss-Prot Entry Name
| CMTR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133559 |
| GeneCard ID
| CMTR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
