<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:28:42 UTC</creation_date>
  <update_date>2020-05-20 21:05:18 UTC</update_date>
  <accession>BMDBP01813</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>HRH1</gene_name>
  <general_function>Involved in histamine receptor activity</general_function>
  <specific_function>In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.</specific_function>
  <pathways>
    <pathway>
      <name>Histamine H1 Receptor Activation</name>
      <smpdb_id>SMP0108002</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000870</accession>
      <name>Histamine</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>22</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1476 bp
ATGACCTGTCCCAACTCCTCCTGCGTCTTCGAAGACAAGATGTGTCAGGGGAATAAGACT
GCCCCTGCCAACGATGCCCAGCTGACGCCCCTGGTGGTGGTCCTGAGCACCATCTCCTTG
GTCACAGTGGGACTCAACCTGCTGGTCCTGTATGCTGTGCGCAGCGAGCGGAAACTACAC
ACCGTGGGGAACCTCTACATCGTCAGCCTCTCAGTGGCCGACCTGATCGTGGGGGTGGTC
GTCATGCCCATGAACATCCTCTACCTCCTCATGTCTAGGTGGTCCCTGGGGCGTCCTCTC
TGCCTCTTCTGGCTTTCCATGGACTATGTGGCCAGCACGGCATCCATTTTCAGCGTCTTC
ATCTTGTGCATTGACCGCTACCGTTCTGTGCAGCAGCCCCTCAAGTACCTGCGGTATCGT
ACCAAGACCCGAGCATCCATCACCATCCTAGCCGCCTGGTTTCTCTCCTTCCTGTGGATT
ATCCCCATTCTGGGCTGGCGTCACTTCCAGCCAAAGACCCCAGAGCCCCGGGAGGACAAG
TGTGAGACGGACTTCTACAACGTCACGTGGTTCAAAGTCATGACCGCCATCATCAACTTC
TACTTGCCCACCTTGCTCATGCTCTGGTTCTATGCCAAGATCTACAAGGCTGTGCGGCAG
CACTGCCAGCACCGGGAGCTCATCAACGGGTCCTTCCCCTCCTTCTCTGACATGAAGATG
AAGCCGGAGAACCTCCAGGTGGGCGCTAAGAAACCGGGGAAGGAGTCCCCCTGGGAGGTT
CTGAAAAGGAAGCCAAAAGACACCGGGGGTGGACCTGTCTTGAAGCCACCATCTCAAGAG
CCAAAAGAGGTGACATCTCCAGGTGTCTTCAGCCAAGAGAAGGAAGAGAAGGATGGAGAA
CTGGGCAAATTCTACTGCTTCCCGCTTGACACTGTGCAGGCGCAGCCGGAGGCAGAGGGG
AGTGGCAGGGGCTACGCAACCATCAACCAGAGCCAGAACCAGCTTGAGATGGGTGAGCAG
GGCCTGAGCATGCCTGGGGCTAAGGAGGCCTTAGAGGATCAGATCCTAGGTGACAGCCAG
TCCTTCTCCCGGACAGACTCGGACACCCCCGCAGAGCCGGCACCAGCGAAAGGCAAGTCG
CGAAGCGAGTCTAGCACAGGCCTGGAGTACATCAAGTTCACTTGGAAGAGGCTCCGCTCG
CATTCGAGACAGTACGTGTCTGGCTTGCACATGAACCGAGAGCGGAAGGCCGCCAAGCAG
TTGGGTTTTATCATGGCGGCCTTCATCATCTGCTGGATTCCTTACTTCATCTTCTTCATG
GTCATTGCCTTCTGTGAGAGCTGCTGCAACCAGCATGTGCACATGTTCACCATCTGGCTG
GGCTACATCAACTCCACGCTGAACCCCCTCATCTACCCCTTGTGCAATGAGAACTTCAAG
AAGACCTTCAAGAAAATTCTGCACATTCGTTCCTAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>491</residue_number>
    <molecular_weight>55957.0</molecular_weight>
    <theoretical_pi>9.25</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>31-53</region>
      <region>64-84</region>
      <region>103-124</region>
      <region>145-165</region>
      <region>191-211</region>
      <region>421-442</region>
      <region>455-474</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Histamine H1 receptor
MTCPNSSCVFEDKMCQGNKTAPANDAQLTPLVVVLSTISLVTVGLNLLVLYAVRSERKLH
TVGNLYIVSLSVADLIVGVVVMPMNILYLLMSRWSLGRPLCLFWLSMDYVASTASIFSVF
ILCIDRYRSVQQPLKYLRYRTKTRASITILAAWFLSFLWIIPILGWRHFQPKTPEPREDK
CETDFYNVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINGSFPSFSDMKM
KPENLQVGAKKPGKESPWEVLKRKPKDTGGGPVLKPPSQEPKEVTSPGVFSQEKEEKDGE
LGKFYCFPLDTVQAQPEAEGSGRGYATINQSQNQLEMGEQGLSMPGAKEALEDQILGDSQ
SFSRTDSDTPAEPAPAKGKSRSESSTGLEYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQ
LGFIMAAFIICWIPYFIFFMVIAFCESCCNQHVHMFTIWLGYINSTLNPLIYPLCNENFK
KTFKKILHIRS</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>BAA01045.1</genbank_protein_id>
  <uniprot_id>P30546</uniprot_id>
  <uniprot_name>HRH1_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>D10197</genbank_gene_id>
  <genecard_id>HRH1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
