1.0 2018-05-07 22:28:52 UTC 2020-05-20 21:06:03 UTC BMDBP01848 Enzyme GLRA1 Involved in chloride ion binding Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization (By similarity). Plays an important role in the down-regulation of neuronal excitability (PubMed:11178872). Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity). BMDB0000123 Glycine BMDB0000251 Taurine BMDB0000492 Chlorine 7 >1374 bp ATGTACAGCTTCAATACTCTTCGACTCTACCTTTGGGAGACCATTGTATTCTTCAGTCTT GCTGCTTCCAAGGAGGCTGAAGCTGCTCGGTCTGCTTCCAAGCCCATGTCACCGTCCGAT TTCCTGGATAAACTCATGGGGAGGACTTCTGGATACGACGCCAGGATCAGGCCCAATTTC AAAGGTCCCCCAGTGAATGTCAGCTGCAACATTTTCATCAACAGCTTCGGTTCCATTGCT GAGACAACTATGGACTACAGGGTCAACATCTTCCTGCGGCAGCAGTGGAATGACCCCCGG CTGGCCTACAATGAATACCCCGATGACTCGCTGGACTTGGACCCATCCATGTTGGACTCC ATCTGGAAACCTGACCTGTTCTTTGCCAATGAGAAGGGGGCCCACTTCCATGAGATCACC ACAGACAACAAACTGCTGAGGATCTCCCGGAACGGGAATGTCCTCTACAGCATTAGGATC ACCCTGACATTGGCCTGCCCCATGGACTTGAAGAATTTCCCCATGGATGTCCAGACGTGC ATTATGCAACTGGAAAGCTTTGGATACACCATGAACGACCTCATCTTTGAGTGGCAGGAG CAGGGGGCTGTGCAGGTGGCAGATGGACTAACTCTACCCCAGTTTATCCTGAAAGAGGAG AAGGACTTGAGATACTGCACCAAGCATTACAACACAGGCAAATTCACCTGCATCGAGGCC CGGTTCCACCTGGAGCGACAGATGGGCTACTACCTGATCCAGATGTACATCCCCAGCCTG CTCATTGTCATCCTCTCGTGGATCTCCTTCTGGATCAACATGGATGCTGCTCCCGCCCGT GTGGGCCTGGGCATCACCACTGTGCTCACCATGACCACCCAGAGCTCCGGCTCTCGAGCA TCCCTGCCCAAGGTATCGTATGTGAAGGCCATCGACATTTGGATGGCCGTGTGCCTGCTC TTTGTGTTCTCAGCCCTGCTTGAGTACGCCGCCGTCAACTTTGTGTCTCGGCAGCACAAA GAGCTGCTCCGATTCAGGAGGAAGCGAAGACATCACAAGAGCCCCATGTTGAATCTGTTC CAGGAGGATGAGGCTGGAGAGGGCCGCTTCAACTTCTCGGCCTACGGCATGGGCCCAGCC TGCCTTCAGGCCAAGGATGGCATCTCTGTCAAGGGCGCCAACAACAGCAACACGACCAAC CCTCCTCCGGCACCATCCAAGTCCCCGGAGGAGATGCGAAAACTCTTCATCCAGCGGGCC AAGAAGATCGACAAGATCTCCCGCATCGGCTTCCCCATGGCCTTCCTCATCTTCAACATG TTCTACTGGATCATCTACAAAATCGTCCGCAGGGAGGACGTCCACAACCAGTGA 457 52614.0 9.04 251-272 278-298 310-330 426-446 1-28 >Glycine receptor subunit alpha-1 MYSFNTLRLYLWETIVFFSLAASKEAEAARSASKPMSPSDFLDKLMGRTSGYDARIRPNF KGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDS IWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTC IMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEA RFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRA SLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLF QEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ AAG14346.1 P57695 GLRA1_BOVIN AF268375 GLRA1