| Identification |
|---|
| BMDB Protein ID
| BMDBP01954 |
| Secondary Accession Numbers
| None |
| Name
| Natural resistance-associated macrophage protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC11A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q43-q44 |
| SNPs
| SLC11A1 |
| Gene Sequence
|
>1647 bp
ATGTCAGGTGACACGGGCCCCCCAAAGCAGGGAGGGACCAGATATGGCTCCATCTCCAGC
CCACCCAGTCCAGAGCCACAGCAAGCACCTCCCGGAGGGACCTACCTAAGTGAGAAGATC
CCCATTCCGGATACAGAATCGGGTACATTCAGCCTGAGGAAGCTGTGGGCCTTCACGGGG
CCTGGATTCCTCATGAGCATCGCATTCCTGGACCCAGGAAACATTGAGTCGGATCTTCAG
GCTGGGGCTGTGGCTGGATTCAAACTGCTCTGGGTGCTGCTGTGGGCCACAGTGTTGGGC
TTGCTTTGCCAGCGACTGGCTGCCCGGCTGGGCGTGGTGACAGGCAAGGACTTGGGCGAG
GTCTGCCATCTCTACTACCCTAAGGTGCCCCGCATTCTCCTCTGGCTGACCATCGAGCTA
GCCATCGTGGGCTCAGACATGCAGGAAGTCATTGGCACAGCTATTGCATTCAGTCTGCTC
TCCGCCGGACGAATCCCACTCTGGGGTGGTGTCCTCATCACCGTCGTGGACACTTTCTTC
TTCCTCTTCCTCGATAACTACGGGTTGCGGAAGCTGGAAGCCTTTTTTGGATTTCTTATT
ACCATAATGGCCTTGACCTTCGGCTATGAGTACGTGGTGGCTCAGCCTGCTCAGGGAGCA
TTGCTTCAGGGCCTGTTCCTGCCCTCGTGCCCAGGCTGTGGCCAGCCCGAGCTGCTGCAA
GCCGTGGGCATCATTGGCGCCATCATCATGCCCCACAACATCTACCTGCATTCCTCCCTG
GTCAAGTCTCGAGAGGTAGACCGGTCCCGGCGGGCGGACATCCGAGAGGCCAACATGTAC
TTCCTGATTGAAGCCACCATCGCCCTGTCTGTCTCCTTCCTCATCAACCTGTTTGTCATG
GCTGTCTTTGGGCAAGCCTTCTACAAGCAAACCAACCAGGCTGCGTTCAACATCTGTGCC
GACAGCAGCCTCCACGACTACGCGCCGATCTTTCCCAGGAACAACCTGACCGTGGCAGTG
GACATTTACCAAGGAGGCGTGATCCTGGGCTGCCTCTTTGGTCCTCCAGCCCTGTACATC
TGGGCCGTGGGTCTCCTGGCTGCTGGGCAGAGCTCCACCATGACCGGCACCTACGCGGGA
CAGTTTGTGATGGAGGGCTTCCTGAAGCTGCGGTGGTCACGCTTCGCCCGAGTCCTGCTC
ACTCGCTCCTGCGCCATCCTGCCCACTGTGCTCCTGGCTGTCTTCAGGGACTTGCGGGAC
CTGTCAGGCCTCAACGACCTGCTCAATGTGCTGCAGAGCCTGCTGCTTCCCTTCGCTGTG
CTGCCCATCCTCACCTTCACCAGCATGCCCGCCCTGATGCAGGAGTTTGCCAATGGCCTG
GTGAGCAAAGTTATCACTTCCTCCATCATGGTGCTGGTCTGCGCCGTCAACCTTTACTTC
GTGATCAGCTACTTGCCCAGCCTCCCCCACCCTGCCTACTTCAGCCTTGTAGCACTGCTG
GCCGCAGCCTACCTGGGCCTCACCACTTACCTGGTCTGGACCTGTCTCATCACCCAGGGA
GCCACTCTTCTGGCCCACAGTTCCCACCAACGCTTCCTGTATGGGCTTCCTGAAGAGGAT
CAGGAGAAGGGGAGGACCTCGGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 548 |
| Molecular Weight
| 59568.0 |
| Theoretical pI
| 6.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 56-73
- 83-102
- 140-160
- 165-184
- 194-214
- 238-256
- 285-304
- 347-366
- 398-415
- 427-447
- 464-485
- 494-513
|
| Protein Sequence
|
>Natural resistance-associated macrophage protein 1
MSGDTGPPKQGGTRYGSISSPPSPEPQQAPPGGTYLSEKIPIPDTESGTFSLRKLWAFTG
PGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGE
VCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAIAFSLLSAGRIPLWGGVLITVVDTFF
FLFLDNYGLRKLEAFFGFLITIMALTFGYEYVVAQPAQGALLQGLFLPSCPGCGQPELLQ
AVGIIGAIIMPHNIYLHSSLVKSREVDRSRRADIREANMYFLIEATIALSVSFLINLFVM
AVFGQAFYKQTNQAAFNICADSSLHDYAPIFPRNNLTVAVDIYQGGVILGCLFGPPALYI
WAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLLAVFRDLRD
LSGLNDLLNVLQSLLLPFAVLPILTFTSMPALMQEFANGLVSKVITSSIMVLVCAVNLYF
VISYLPSLPHPAYFSLVALLAAAYLGLTTYLVWTCLITQGATLLAHSSHQRFLYGLPEED
QEKGRTSG
|
| External Links |
|---|
| GenBank ID Protein
| AAA82582.1 |
| UniProtKB/Swiss-Prot ID
| Q27981 |
| UniProtKB/Swiss-Prot Entry Name
| NRAM1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U12862 |
| GeneCard ID
| SLC11A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
