| Identification |
|---|
| BMDB Protein ID
| BMDBP02014 |
| Secondary Accession Numbers
| None |
| Name
| Adhesion G protein-coupled receptor L3 |
| Synonyms
|
Not Available
|
| Gene Name
| ADGRL3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor activity |
| Specific Function
| Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| ADGRL3 |
| Gene Sequence
|
>4512 bp
ATGTGGCCATCACAGCTACTAGTCTTCATGATGCTCTTAGCACCGATAATTCATGCTTTC
AGCCGTGCCCCCATTCCGATGGCTGTGGTTCGCAGAGAGCTCTCCTGTGAGAGTTACCCC
ATTGAGCTTCGCTGTCCAGGAACAGATGTCATCATGATTGAAAGTGCCAACTATGGGAGG
ACTGATGACAAAATCTGTGACTCTGACCCTGCTCAGATGGAGAATATACGATGCTATCTG
CCTGATGCCTATAAGATTATGTCTCAAAGGTGCAATAACAGAACCCAATGTGCAGTGGTG
GCAGGTCCTGATGTTTTTCCAGACCCTTGTCCAGGAACCTATAAATACCTTGAAGTGCAG
TATGAATGTGTTCCTTACAAAGTGGAACAAAAAGTTTTTCTTTGTCCTGGACTACTAAAA
GGAGTATACCAGAGTGAACATTTGTTTGAATCTGACCACCAATCTGGGGCATGGTGCAAA
GACCCTCTTCAGGCTTCTGACAAGATTTATTATATGCCCTGGACCCCATACAGAACTGAT
ACCCTGACTGAGTACTCATCCAAGGATGACTTCATTGCTGGAAGGCCAACTACAACCTAC
AAGCTCCCTCACAGGGTGGATGGCACAGGATTTGTAGTGTATGATGGAGCTTTGTTCTTC
AATAAAGAGCGCACCAGAAACATAGTAAAGTTTGATTTGCGGACTAGGATAAAGAGTGGA
GAAGCTATCATAGCAAATGCCAATTACCATGATACCTCCCCTTACCGCTGGGGAGGCAAA
TCTGACATAGACTTGGCAGTGGACGAGAATGGGCTATGGGTCATCTATGCAACAGAACAA
AACAATGGTAAAATTGTCATTAGTCAATTGAACCCTTACACCCTACGGATTGAAGGGACA
TGGGATACTGCATATGATAAAAGATCAGCTTCCAATGCATTCATGATATGTGGAATTCTG
TATGTGGTCAAATCTGTCTATGAGGATGACGACAATGAGGCCACGGGAAATAAGATTGAC
TACATTTACAACACTGACCAAAGTAAGGACAGTTTGGTGGATGTGCCCTTTCCTAATTCA
TACCAGTACATAGCAGCTGTGGATTACAACCCCCGGGACAACCTTCTTTATGTGTGGAAT
AACTATCACGTCGTGAAATATTCTTTGGATTTTGGACCTCTGGATAGTAGATCAGGGCAG
GCACATCATGGACAGGTATCATACATCTCTCCACCAATTCACCTTGACTCTGACCTGGAA
AGACCCCCTGTTAGAGAAATCTCTACCACAGGACCTCTTGGCACGGGAAGTACCACCACC
AGTACCACCCTTCGGACCACAACCTGGAGCCCAGGCAGGAGTACCACCCCCTCAGTGTCA
GGAAGAAGAAACCGGAGTACCAGCACCCCATCTCCAGCTATCGAGGTGCTTAATGACATT
ACCACACACGTTCCATCAGCATCGCCCCAAATCCCAGCTCTGGAAGAGAGCTGTGAGGCT
GTGGAAGCTCGTGAAATCATGTGGTTTAAGACGCGTCAAGGACAGATGGCGAAGCAGCCA
TGCCCTGCAGGAACTATAGGAGTATCAACTTATCTCTGCCTGGCTCCTGATGGAATCTGG
GACCCCCAGGGACCAGACCTTAGCAACTGTTCTTCTCCTTGGGTCAACCATATAACACAG
AAGTTGAAATCTGGAGAGACAGCCGCCAACATTGCTAGAGAACTGGCTGAACAGACACGA
AATCATTTGAATGCTGGAGATATCACTTATTCTGTCCGGGCCATGGATCAGTTGGTAGGC
CTCCTAGATGTACAGCTCCGGAACTTGACTCCAGGTGGAAAAGATAGTGCTGCACGAAGT
TTGAACAAGCTTCAGAAAAGAGAGCGCTCTTGCAGAGCCTATGTCCAGGCAATGGTCGAG
ACAGTTAACAACCTCCTCCAGCCACAAGCCTTGAATGCCTGGAGAGACCTGACTACAAGT
GATCAACTGCGTGCAGCCACCATGTTGCTTGACACTGTGGAGGAAAGTGCCTTTGTGCTG
GCCGATAACCTTTTGAAGACTGACATTGTCAGGGAGAACACAGACAATATTCAATTGGAA
GTTGCAAGGCTGAGCACAGAAGGAAACTTAGAGGACCTGAAATTTCCAGAAAACACCGGT
CATGGAAGCACTATCCAGCTTTCTGCAAATACTCTAAAACAAAATGGCCGAAATGGAGAG
ATCAGAGTGGCCTTTGTCCTTTATAACAACTTGGGTCCTTATTTGTCCACGGAGAATGCC
AGCATGAAGTTAGGAACAGAGGCCATGTCCACCAATCATTCTGTTATCGTCAATTCTCCA
GTTATTACAGCAGCCATAAACAAAGAGTTCAGTAATAAGGTTTATTTGGCTGATCCTGTG
GTGTTCACTGTTAAACACATCAAGCAGTCTGAGGAAAACTTCAATCCTAACTGTTCATTT
TGGAGCTATTCCAAGCGCACAATGACAGGTTACTGGTCAACCCAAGGCTGTCGGCTCCTG
ACAACAAATAAGACACATACTACATGCTCTTGTAACCACCTAACCAATTTTGCAGTACTG
ATGGCACATGTGGAAGTTAAGCATAGTGATGCTGTCCATGACCTCCTTCTGGATGTGATC
ACCTGGGTTGGAATTTTGCTGTCCCTTGTGTGCCTCCTGATTTGCATCTTCACATTTTGC
TTTTTCCGTGGGCTCCAGAGTGACCGTAACACCATCCATAAGAACCTCTGCATCAGCCTT
TTTGTAGCAGAACTGCTCTTCTTGATTGGGATCAACAGAACAGATCAACCAATTGCCTGT
GCAGTTTTTGCTGCCCTATTGCATTTCTTCTTCTTGGCTGCCTTCACCTGGATGTTCCTG
GAGGGAGTGCAGCTCTATATCATGCTGGTAGAGGTTTTTGAGAGTGAACATTCACGAAGG
AAATACTTCTACCTGGTTGGCTATGGGATGCCTGCCCTCATTGTGGCTGTGTCAGCTGCT
GTAGACTATAGGAGTTATGGAACTGATAAAGTATGTTGGCTCCGTCTTGACACCTACTTC
ATTTGGAGTTTTATAGGACCAGCGACCTTGATAATTATGCTTAATGTAATCTTCCTTGGG
ATTGCTTTATATAAAATGTTTCATCACACTGCCATTCTGAAACCTGAATCTGGCTGTCTT
GATAATATCAAGTCATGGGTTATAGGTGCAATAGCTCTTCTCTGCCTATTAGGATTGACC
TGGGCCTTTGGACTCATGTATATTAATGAAAGCACAGTCATCATGGCGTATCTCTTCACC
ATTTTCAATTCTCTACAGGGAATGTTTATATTCATTTTCCATTGTGTCCTACAAAAGAAG
GTACGAAAAGAGTATGGGAAATGCCTGCGAACACACTGCTGTAGTGGCAGAAGTACAGAG
AGCTCCATTGGCTCAGGGAAAACATCTGGTTCTCGGACTCCTGGGCGCTACTCCACAGGC
TCACAGAGCCGAATTCGTAGAATGTGGAATGATACGGTCCGAAAGCAGTCAGAGTCTTCC
TTCATTACTGGAGATATAAACAGTTCAGCGTCACTCAACAGAGGAGCCATGGCTAATCAT
CTTATAAGCAATGCTCTGCTTCGTCCGCATGGTACTAACAATCCCTATAATACATTGCTT
GGGGAACCGGCGGTCTGTAACAACCCTTCTGTCAGCATGTACAACGCACAAGAGGGGCTT
CTGAACAATGCCAGGGATACAAGTGTCATGGATACTCTACCACTGAATGGTAACCATGGC
AATAGTTACAGCATTGCCAGTGGTGAATACCTGAGCAACTGTGTGCAAATCATAGACCGT
GGCTATAACCATAACGAGACCGCCCTAGAGAAAAAGATTCTGAAGGAACTCACTTCCAAC
TATATCCCGTCTTACCTGAATAACCATGAGCGCTCCAGCGAACAGAACAGGAATCTGATG
AACAAGCTGGTGAACAACCTGGGCAGTGGGAGTGAAGATGATGCCATTGTCCTGGATGAT
GCCACCTCCTTTAACCATGAGGAAAGTCTGGGCCTGGAATTGATTCATGAGGAATCAGAT
GCTCCTTTGCTGCCCCCAAGAGTCTACTCCACAGAGAACCATCAGCTACACCATTATACC
AGAAGGCGGATCCCCCAAGACCACAGTGAGAGCTTTTTCCCTTTGCTAACCAACGAGCAC
ACAGAAGATCTCCAGTCACCCCACAGGGACTCTCTCTACACCAGCATGCCAGCGCTGGCT
GGTGTGCCCACTGCAGAGAGTGTTACCACCAGCACCCAGACGGAACCCCCACCGGCCAAA
TGTGGCGATGCTGAAGATGTTTACTACAAAAGCATGCCAAACCTAGGCTCCAGAAACCAC
GTCCATCAGCTACACACCTACTACCAGCTAGGTCGCGGTAGCAGTGATGGGTTTATAGTT
CCTCCAAACAAAGATGGGACCCCTCCAGAGGGAAGTTCAAAAGGACCAGCTCATTTGGTC
ACTAGCCTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1580 |
| Molecular Weight
| 176051.0 |
| Theoretical pI
| 6.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 950-970
- 979-999
- 1008-1028
- 1051-1071
- 1089-1109
- 1143-1163
- 1170-1190
|
| Protein Sequence
|
>Latrophilin-3
MWPSQLLVFMMLLAPIIHGGKHSERHPALASPLRHAERGPGGALPPRHLLQQPAAERATA
HRGPGPRGATRGVRGPGAHGAQISAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIM
IESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPG
TYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYM
PWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFD
LRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNP
YTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSL
VDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPP
IHLDSDLERPPVREISTTGPLGTGSTTTSTTLRTTTWSPGRSTTPSVSGRRNRSTSTPSP
AIEVLNDITTHVPSASPQIPALEESCEAVEAREIMWFKTRQGQMAKQPCPAGTIGVSTYL
CLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSV
RAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALN
AWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLED
LKFPENTGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTN
HSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYW
STQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCL
LICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFL
AAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVC
WLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFI
KSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRK
EYGKCLRTHCCSGRSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFIT
GDINSSASLNRGAMANHLISNALLRPHGTNNPYNTLLGEPAVCNNPSVSMYNAQEGLLNN
ARDTSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIP
SYLNNHERSSEQNRNLMNKLVNNLGSGSEDDAIVLDDATSFNHEESLGLELIHEESDAPL
LPPRVYSTENHQLHHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPALAGVP
TAESVTTSTQTEPPPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPN
KDGTPPEGSSKGPAHLVTSL
|
| External Links |
|---|
| GenBank ID Protein
| AAD05321.1 |
| UniProtKB/Swiss-Prot ID
| O97827 |
| UniProtKB/Swiss-Prot Entry Name
| AGRL3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF111085 |
| GeneCard ID
| ADGRL3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
