| Identification |
|---|
| BMDB Protein ID
| BMDBP02038 |
| Secondary Accession Numbers
| None |
| Name
| Adhesion G protein-coupled receptor L2 |
| Synonyms
|
Not Available
|
| Gene Name
| ADGRL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor activity |
| Specific Function
| Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ADGRL2 |
| Gene Sequence
|
>4200 bp
ATGGTGTCTTCTGGTTGCAGAATGCGAAGTCTGTGGTTTATCATTATAATCAGCTTCTTA
CCGAATACAGAAGGTTTCAGCAGAGCAGCTTTGCCATTTGGGTTAGTTCGTCGAGAATTA
TCCTGTGAAGGTTATTCTATAGATCTGCGATGTCCAGGCAGTGATGTCATAATGATTGAG
AGTGCTAATTATGGTCGGACAGACGACAAGATTTGTGATGCTGACCCATTTCAGATGGAG
AATACAGACTGCTACCTCCCAGATGCCTTCAAAATTATGACTCAAAGGTGCAACAATCGA
ACACAGTGTATAGTAGTTACTGGGTCAGATGTATTTCCTGATCCATGTCCCGGAACATAC
AAATATCTTGAGGTCCAATATGAATGTGTCCCTTACATGGAGCAAAAAGTTTTTGTGTGC
CCTGGGACCTTGAAAGCAATTGTGGACTCACCATGTATATATGAAGCTGAACAAAAGGCA
GGTGCTTGGTGCAAGGACCCTCTTCAGGCTGCAGATAAAATTTATTTCATGCCCTGGACT
CCCTATCGTACTGATACTTTAATAGAATATGCATCTTTAGAAGATTTCCAAAACAGTCGC
CAAACAACAACCTATAAACTTCCAAATCGAGTAGATGGTACTGGATTTGTGGTATATGAT
GGTGCTGTCTTCTTTAACAAAGAAAGAACAAGGAATATTGTGAAATATGACTTGAGGACT
AGAATTAAGAGTGGAGAGGCCATAATTAACTATGCTAACTATCATGATACTTCACCATAT
AGATGGGGAGGAAAAACTGATATTGACCTAGCAGTTGATGAAAATGGCTTATGGGTCATT
TATGCCACTGAGCAGAACAATGGAATGATAGTTATTAGCCAACTGAATCCATACACTCTT
CGATTTGAAGCAACGTGGGAGACTGTATATGACAAACGAGCTGCCTCAAATGCTTTTATG
ATCTGTGGAGTCCTTTATGTGGTCAGGTCAGTTTATCAAGACAATGAGAGTGAAACAGGC
AAGAATGCAATTGATTATATTTACAATACCCGATTAAACCGAGGAGAATATGTAGATGTT
CCCTTCCCCAACCAGTACCAGTATATTGCTGCGGTGGATTACAATCCAAGAGATAACCAA
CTCTATGTGTGGAACAATAACTTCATTTTACGATATTCTCTGGAGTTTGGTCCACCTGAT
CCTGCCCAAGAGAGATTCTGCGAAGCATTAGACGCGAGGGGGATAAGGTGGCCTCAGACA
CAAAGGGGAATGATGGTTGAACGACCGTGTCCCAAGGGAACGAGAGGAACTGCCTCGTAT
CTCTGCGTGCTTTCCACTGGAACATGGAACCCTAAGGGCCCTGATCTTAGCAACTGTACC
TCACACTGGGTAAATCAGCTGGCTCAGAAGATTAGAAGCGGAGAAAATGCTGCTAGCCTT
GCCAATGAACTGGCTAAACATACCAAAGGGCCAGTGTTTGCTGGTGATGTGAGTTCTTCA
GTGAGATTGATGGAGCAGTTGGTGGACATTCTTGATGCACAGCTGCAGGAACTGAAACCT
AGTGAAAAGGATTCAGCTGGACGGAGTTATAACAAGGCAATTGTTGATACAGTGGACAAT
CTTCTGAGACCTGAAGCTTTGGAATCATGGAAACACATGAATTCTTCTGAACAAGCACAT
ACTGCAACGATGTTGCTGGATACATTGGAAGAAGGAGCGTTTGTCCTGGCTGATAACCTC
GTAGAACCAACCAGGGTGTCAATGCCCACAGAAAATATTGTTCTGGAAGTTGCAGTACTC
AGTACAGAAGGACAGGTCCAAGACTTTAAATTTCCTCTGGGCATCAAAGGAGCAGGCAGC
TCAATCCAACTCTCTGCAAATACTGTTAAACAGAACAGCAGGAATGGTCTTGCAAAGTTG
GTGTTCATCATTTACCGGAGTTTGGGACAGTTCCTTAGTACCGAAAATGCAACCATAAAA
CTGGGTGCTGACTTTATTGGTCGAAATAGCACCATTGCAGTGAATTCTCACGTCATTTCG
GTTTCAATCAATAAAGAATCCAGCCGAGTATACTTGACAGATCCTGTGCTTTTTACCCTA
CCACACATTGATCCTGACAATTATTTCAATGCAAACTGCTCCTTCTGGAACTACTCAGAG
AGAACTATGATGGGATATTGGTCTACCCAGGGCTGCAAGCTGGTTGACACTAATAAAACT
CGTACGACGTGTGCATGCAGCCACCTAACCAATTTTGCAATTCTCATGGCCCACAGGGAA
ATTGCATACAAAGATGGAGTTCACGAATTACTCCTTACAGTCATCACCTGGGTGGGAATT
GTCATTTCCCTTGTTTGTCTGGCTATCTGCATCTTCACTTTCTGCTTTTTCCGTGGTCTA
CAGAGTGACCGTAATACCATTCACAAGAACCTTTGTATCAACCTTTTTATTGCTGAATTT
ATTTTCCTAATAGGCATTGATAAGACAAAATACATGATTGCATGCCCAATATTTGCAGGA
CTGTTACACTTTTTCTTTTTGGCTGCTTTTGCTTGGATGTGTCTAGAAGGTGTACAGCTC
TACCTAATGTTAGTTGAAGTCTTTGAAAGTGAATATTCAAGAAAGAAATACTACTATGTT
GCCGGTTACTTGTTTCCTGCCACAGTGGTTGGAGTTTCAGCTGCTATTGACTATAAGAGC
TATGGAACAGAAAAAGCTTGCTGGCTTCATGTTGATAACTATTTTATATGGAGTTTCATT
GGACCTGTTACCTTCATTATTCTGCTAAATATTATCTTTCTGGTGATCACATTATGCAAA
ATGGTGAAGCACTCGAACACATTAAAACCAGATTCTAGCAGGTTGGAAAACATTAATAAT
TACCGTGTTTGTGATGGCTACTATAATACGGACTTACCTGGGTCTTGGGTGCTTGGCGCA
TTTGCTCTTCTATGTCTTCTTGGCCTAACCTGGTCATTCGGGTTGCTTTTTATTAATGAG
GAGACTATTGTGATGGCATATCTCTTCACCATCTTTAATGCTTTCCAGGGAGTGTTCATT
TTCATCTTTCACTGTGCTCTCCAAAAGAAAGTACGAAAAGAATATGGCAAGTGCTTCAGA
CATTCATACTGCTGCGGCGGCCTCCCGACTGAGAGTCCCCACAGCTCAGTGAAGGCATCC
ACTACCAGAACCAGTGCTCGCTATTCCTCTGGCACACAGAGTCGTATAAGAAGGATGTGG
AATGACACTGTGAGAAAACAATCTGAATCTTCTTTTATCTCAGGTGACATCAATAGCACT
TCAACACTTAATCAAGGAATGACTGGCAATTACCTACTAACAAACCCTCTTCTTCGACCC
CACGGCACTAACAACCCCTATAACACATTGCTCGCTGAAACAGTTGTATGTAATGCCCCT
TCAGCTCCTGTGTTTAACTCACCAGGACATTCACTGAACAATGCCAGGGATACAAGTGCC
ATGGATACTCTACCGCTAAATGGTAATTTTAACAACAGCTACTCACTGCGCAAGGGGGAC
TATAATGACAGTGTGCAGGTTGTGGACTGTGGACTAAGTCTGAATGATACTGCTTTTGAG
AAGATGATCATTTCAGAATTAGTGCACAACAACCTACGGGGCAGCAGCAAGGCTCACAAC
CTCGAGCTCACACTACCAGTCAAGCCTGTGATTGGAGGGAGCAGCAGCGAAGATGATGCT
ATTGTGGCAGATGCTTCATCTCTCATGCATGGTGACAATCCTGGACTGGAGCTCCATCAC
AAAGAACTCGAGGCCCCGCTCATCCCTCAGAGGACTCACTCCCTTCTGTACCAACCCCAG
AAGAAAGCAAAGCCCGAGGGGACTGACAGCTACGTATCCCAGCTGACAGCCGAGGCCGAG
GACCATCTCCAGTCCCCCAACAGAGACTCTCTGTACACAAGTATGCCTAACCTTAGGGAC
TCTCCCTATCAGGAGAGCAGCCCCGACATGGAAGAAGACCTGTCTCCGTCCCGGAGGAGT
GAGAATGAGGACATCTACTATAAGAGCATGCCAAACCTTGGAGCTGGCCACCAGCTTCAG
ATGTGCTACCAGATCAGCAGGGGCAATAGCGATGGTTACATAATCCCCATTAACAAAGAA
GGGTGTATTCCAGAAGGAGATGTCAGAGAAGGACAAATGCAGCTGGTGACAAGTCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1478 |
| Molecular Weight
| 165547.0 |
| Theoretical pI
| 6.3 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 856-876
- 885-905
- 912-932
- 956-976
- 995-1015
- 1057-1077
- 1082-1102
|
| Protein Sequence
|
>Latrophilin-2
MVSSGCRMRSLWFIIIISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE
SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY
KYLEVQYECVPYMEQKVFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWT
PYRTDTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKYDLRT
RIKSGEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTL
RFEATWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNAIDYIYNTRLNRGEYVDV
PFPNQYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAEMFKT
TVSTTSTTSQKGPMSTTVAGSQEGSKGTKAPPAVSTTKIPPVTNIFPLPERFCEALDARG
IRWPQTQRGMMVERPCPKGTRGTASYLCVLSTGTWNPKGPDLSNCTSHWVNQLAQKIRSG
ENAASLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQ
KREKTCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLV
EPTRVSMPTENIVLEVAVLSTEGQVQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLV
FIIYRSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLP
HIDPDNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREI
AYKDGVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFI
FLIGIDKTKYMIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVA
GYLFPATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKM
VKHSNTLKPDSSRLENINNYRVCDGYYNTDLPGSWVLGAFALLCLLGLTWSFGLLFINEE
TIVMAYLFTIFNAFQGVFIFIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKAST
TRTSARYSSGTQSRIRRMWNDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPH
GTNNPYNTLLAETVVCNAPSAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLRKGDY
NDSVQVVDCGLSLNDTAFEKMIISELVHNNLRGSSKAHNLELTLPVKPVIGGSSSEDDAI
VADASSLMHGDNPGLELHHKELEAPLIPQRTHSLLYQPQKKAKPEGTDSYVSQLTAEAED
HLQSPNRDSLYTSMPNLRDSPYQESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQM
CYQISRGNSDGYIIPINKEGCIPEGDVREGQMQLVTSL
|
| External Links |
|---|
| GenBank ID Protein
| AAD05308.1 |
| UniProtKB/Swiss-Prot ID
| O97817 |
| UniProtKB/Swiss-Prot Entry Name
| AGRL2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF111072 |
| GeneCard ID
| ADGRL2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
