1.0 2018-05-07 22:30:14 UTC 2020-05-20 21:52:42 UTC BMDBP02145 Enzyme ANGPTL4 Involved in receptor binding Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro) (By similarity). Depending on context, may modulate tumor-related angiogenesis (By similarity). BMDB0000122 D-Glucose 7 >1233 bp ATGCGCTGTGCGCCGACAGCCGGAGCAGCCCTGATGCTGTGCGCCGCCACCGCCGGGCTG CTGAGCGCTCAGGGCCGCCCGGAGCCTCCCGAGACGCCGCGCTTTGCTTCCTGGGACGAG GTGAACGTGCTGGCACACGGCCTCTTGCAGCTCGGCCACGGGCTGCGCGAACACGTGGAG CGCACCCGTGGGCAGCTGGGCGAGCTGGAACGGCGTCTGGGCGCGTGTGGGGCCGCCTGC AAGGATCCTGAGGGGTCCGCCGCGCCTCCGCGTGCCCAGGCCAATTTGGTCAATCCCGGC GGCGGCGACGCCTCCCCAGAAACCCTCCGCAGCTTGAAGACTCAGCTGGAGGCTCAGAAC AGCAGGATCCAGCAACTCTTCCAGAAGGTGGCCCAGCAGCAGCGGCACTTGGAGAAGCAG CAGCTGCGAATCCAGAATCTACAGAGCCAGATGGATCACCTGGCCCCCAGGCACCTGGGC CACGAGATGGCCAAGCCCGCCAGGAGGAAGAGGCTGCCCAAGATGGCCCAGCTTGCTGGC CCAGCTCACAATATCAGCCGCCTGCACAGACTGCCCAGGGACTGCCAGGAGCTGTTTGAA GAGGGAGAGAGGGAAAGTGGATTGTTCCAGATCCAGCCCCAGGGATCCCCGCCTTTCCTG GTTAACTGCAAAATGACCTCAGATGGAGGCTGGACCGTAATTCAGAGGCGTCAGGATGGC TCCGTGGACTTTAACCAGCCCTGGGAAGCCTACAAAGATGGCTTCGGAGACCCCCAAGGC GAGTTCTGGCTGGGCCTGGAGAAGGTGCATCACATCCTTGGGGACCGTGGCAGCCGCCTG GCTGTGCAGCTGCAGGACTGGGAGGGCAATGCCGAGTCCTTGCAGTTCCCCATCCACCTG GGGGGTGAAGACACCGCCTACAGCCTGCAGCTCACGCCACCGGTGGCCAGCAAACTGGGC GCCACCACCTTCTCGCCCAGTGGCCTCTCCCTGCCCTTCTCCACTTGGGACCAGGACCAC GACCTCCGCGGAGACAAGAACTGCGCCAGGAGCCTCTCTGGTGGCTGGTGGTTTGGCACC TGCAGTCACTCCAACCTGAACGGCCAGTATTTCCACTCCATTCCAAGGCAGCGGCAGCAG CGTAAGAAGGGCATCTTCTGGAAGACCTGGCGGGGCCGCTACTACCCACTGCAGGCCACC ACCATCCTGGTACAGCCCACAGCGGCCTCCTAG 410 45553.0 8.93 35-56 62-85 167-186 198-218 230-250 262-287 294-315 321-338 1-23 >Angiopoietin-related protein 4 MRCAPTAGAALMLCAATAGLLSAQGRPEPPETPRFASWDEVNVLAHGLLQLGHGLREHVE RTRGQLGELERRLGACGAACKDPEGSAAPPRAQANLVNPGGGDASPETLRSLKTQLEAQN SRIQQLFQKVAQQQRHLEKQQLRIQNLQSQMDHLAPRHLGHEMAKPARRKRLPKMAQLAG PAHNISRLHRLPRDCQELFEEGERESGLFQIQPQGSPPFLVNCKMTSDGGWTVIQRRQDG SVDFNQPWEAYKDGFGDPQGEFWLGLEKVHHILGDRGSRLAVQLQDWEGNAESLQFPIHL GGEDTAYSLQLTPPVASKLGATTFSPSGLSLPFSTWDQDHDLRGDKNCARSLSGGWWFGT CSHSNLNGQYFHSIPRQRQQRKKGIFWKTWRGRYYPLQATTILVQPTAAS ABC84490.1 Q2KJ51 ANGL4_BOVIN DQ355521 ANGPTL4