| Identification |
|---|
| BMDB Protein ID
| BMDBP02169 |
| Secondary Accession Numbers
| None |
| Name
| Estrogen receptor |
| Synonyms
|
Not Available
|
| Gene Name
| ESR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 9 |
| Locus
| Not Available |
| SNPs
| ESR1 |
| Gene Sequence
|
>1791 bp
ATGACCATGACCCTGCACACCAAAGCGTCCGGCATGGCCCTGCTGCACCAGATCCAAGCC
AACGAGCTGGAGCCCCTGAACCGCCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGC
GAGGTGTACATGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCGTAC
GACTTCAACGCCGCGGCCCCCGCCTCCGCGCCCGTCTACGGCCAGTCGGGCCTCCCCTAC
GGCCCCGGGTCCGAGGCGGCGGCGTTCGGCGCCAACGGCCTGGGGGCCTTCCCGCCGCTC
AACAGCGTGTCTCCGAGCCCGCTGGTGCTGCTACACCCGCCTCCGCAGCCACTCTCGCCC
TTCCTGCACCCGCACGGCCAACAGGTGCCCTATTACCTGGAGAACGAGTCGAGCGGCTAT
GCGGTGCGCGAAGCCGGCCCTCCCGCCTACTACAGGCCAAATTCAGATAATCGACGCCAA
GGTGGCAGAGAGAGATTGGCCAGTACCAGTGACAAGGGAAGCATGGCCATGGAATCTGCC
AAGGAGACTCGCTACTGTGCAGTGTGCAATGACTATGCCTCAGGCTACCATTACGGAGTT
TGGTCTTGCGAGGGCTGTAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAATGACTAC
ATGTGTCCGGCCACCAACCAGTGCACGATTGATAAAAACAGGAGGAAGAGCTGTCAGGCC
TGCCGGCTACGCAAGTGCTATGAAGTGGGCATGATGAAAGGCGGAATACGGAAAGACCGA
AGAGGAGGGAGAATGTTGAAGCACAAGCGCCAGAGAGATGATGGGGAGGGCAGGAACGAA
GCGGTGCCCTCCGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCCATCATGATTAAA
CACACTAAGAAGAACAGCCCGGTGTTGTCCCTGACAGCTGACCAGATGATCAGTGCCTTG
CTGGAGGCTGAGCCCCCCATAATCTATTCTGAGTATGACCCTACCAGACCTTTCAGTGAG
GCTTCAATGATGGGCTTGCTGACCAACCTTGCAGACAGGGAGCTGGTACACATGATCAAC
TGGGCAAAGAGGGTGCCAGGATTTGTGGATCTGGCCCTCCATGATCAAGTCCACCTTTTG
GAATGTGCCTGGCTAGAGATCCTCATGATTGGTCTTGTCTGGCGCTCCATGGAGCATCCA
GGGAAGCTCCTATTTGCTCCTAACCTTCTCCTGGACAGGAACCAGGGAAAATGTGTGGAA
GGCATGGTGGAGATCTTTGACATGTTGCTGGCTACTTCGTCTCGGTTCCGTATGATGAAT
CTCCAGGGAGAAGAGTTTGTGTGCCTCAAATCCATCATCTTGCTTAATTCTGGAGTGTAC
ACATTTCTGTCCAGCACTCTGAGGTCTCTGGAAGAGAAGGACCACATCCACCGCGTCCTG
GACAAGATCACAGACACCTTGATCCATCTGATGGCCAAAGCAGGCCTGACTCTGCAGCAG
CAGCACCGGCGTCTGGCCCAACTCCTCCTCATCCTCTCTCACTTCAGGCACATGAGCAAC
AAAGGCATGGAGCATCTATACAGCATGAAGTGCAAGAACGTGGTGCCTCTCTACGACCTG
CTGCTGGAGATGCTGGATGCCCACCGCCTGCACGCCCCAGCCAACTTTGGGAGCGCACCT
CCAGAGGACGTGAATCAGAGCCAGCTGGCCCCCACTGGCTGCACTTCATCGCATTCCTTG
CAAACATATTACATCACTGGGGAGGCAGAGAATTTCCCCAGCACAGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 596 |
| Molecular Weight
| 66489.0 |
| Theoretical pI
| 7.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Estrogen receptor
MTMTLHTKASGMALLHQIQANELEPLNRPQLKIPLERPLGEVYMDSSKPAVYNYPEGAAY
DFNAAAPASAPVYGQSGLPYGPGSEAAAFGANGLGAFPPLNSVSPSPLVLLHPPPQPLSP
FLHPHGQQVPYYLENESSGYAVREAGPPAYYRPNSDNRRQGGRERLASTSDKGSMAMESA
KETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQA
CRLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRNEAVPSGDMRAANLWPSPIMIK
HTKKNSPVLSLTADQMISALLEAEPPIIYSEYDPTRPFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLALHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVE
GMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLRSLEEKDHIHRVL
DKITDTLIHLMAKAGLTLQQQHRRLAQLLLILSHFRHMSNKGMEHLYSMKCKNVVPLYDL
LLEMLDAHRLHAPANFGSAPPEDVNQSQLAPTGCTSSHSLQTYYITGEAENFPSTV
|
| External Links |
|---|
| GenBank ID Protein
| AAS46251.1 |
| UniProtKB/Swiss-Prot ID
| P49884 |
| UniProtKB/Swiss-Prot Entry Name
| ESR1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AY538775 |
| GeneCard ID
| ESR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
