| Identification |
|---|
| BMDB Protein ID
| BMDBP02171 |
| Secondary Accession Numbers
| None |
| Name
| Sphingosine 1-phosphate receptor 1 |
| Synonyms
|
Not Available
|
| Gene Name
| S1PR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in lysosphingolipid and lysophosphatidic acid |
| Specific Function
| G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| S1PR1 |
| Gene Sequence
|
>1149 bp
ATGGGGTCCACCCGTATCCCGCTGGTCAAGGCCCTCCACAGCCCTGTCTCGGACTATGTC
AACTACGACATCATCGTCCGGCATTATAACTACACGGGAAAGCTGAAGATCAGCGCGGAC
AAGGACAATGGCATTAAACTGATCTCAGTGGTGTTCATTCTCATCTGCTGCTTTATCATC
CTAGAGAACATTTTTGTTTTGCTGACCATCTGGAAAACCAAGAAGTTCCACCGACCCATG
TACTATTTTATCGGCAATCTGGCCCTCTCAGACCTGTTGGCGGGAGTGGCCTACACAGCC
AACCTGCTCTTGTCTGGGGCCACCACCTACAAGCTAACCCCCGCCCAGTGGTTTCTGCGG
GAAGGGAGTATGTTTGTGGCCCTCTCGGCCTCCGTGTTCAGCCTCCTGGCCATCGCCATT
GAGCGCTACATCACCATGCTGAAGATGAAACTCCACAATGGGAGCAACAGGTTCCGCTCC
TTCCTGCTCATCAGTGCCTGCTGGGTCATCTCCCTCATCCTGGGGGGCCTGCCTATCATG
GGCTGGAACTGCATCAGCACGCTGCCCAGCTGTTCTACTGTGCTGCCGCTCTACCACAAG
CACTATATCCTCTTCTGCACCACGGTCTTCACTCTGCTCCTGCTCTCCATTGTCATCCTG
TACTGCAGGATCTACTCCTTGGTCAGGACTCGCAGCCGCCGTCTGACCTTCCGCAAGAAC
ATTTCCAAGGCCAGCCGCAGCTCTGAGAAGTCGCTGGCACTGCTCAAGACCGTGATTATT
GTCCTGGGCGTCTTCATCGCCTGCTGGGCACCACTCTTCATCCTGCTCCTGCTCGACGTG
GGCTGCAAGGTGAAGACCTGTGACATCCTCTTCAGAACGGAGTACTTCCTGGTGTTGGCT
GTGCTCAACTCTGGCACCAACCCCATCATTTACACTTTGTCCAACAAGGAGATGCGTCGG
GCCTTCGTCCGGATCATGTCCTGCTGCAAGTGCCCCAGTAGAGACTCCGCGAGTAAATTC
ACACGACCCATCATCGCGGGCATGGAATTCAGCCGCAGTAAGTCAGACAACTCCTCCCAC
CCCCAGAAGGACGATGGGGACAACCCAGAGACCATTATGTCTTCTGGAAACGTCAACTCT
TCTTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 382 |
| Molecular Weight
| 42949.0 |
| Theoretical pI
| 10.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 47-68
- 83-104
- 117-138
- 161-182
- 197-224
- 258-278
- 290-310
|
| Protein Sequence
|
>Sphingosine 1-phosphate receptor 1
MGSTRIPLVKALHSPVSDYVNYDIIVRHYNYTGKLKISADKDNGIKLISVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNRFRSFLLISACWVISLILGGLPIM
GWNCISTLPSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLGVFIACWAPLFILLLLDVGCKVKTCDILFRTEYFLVLA
VLNSGTNPIIYTLSNKEMRRAFVRIMSCCKCPSRDSASKFTRPIIAGMEFSRSKSDNSSH
PQKDDGDNPETIMSSGNVNSSS
|
| External Links |
|---|
| GenBank ID Protein
| AAX08894.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9P3 |
| UniProtKB/Swiss-Prot Entry Name
| S1PR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020877 |
| GeneCard ID
| S1PR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
