| Identification |
|---|
| BMDB Protein ID
| BMDBP02218 |
| Secondary Accession Numbers
| None |
| Name
| Sodium-dependent serotonin transporter |
| Synonyms
|
Not Available
|
| Gene Name
| SLC6A4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serotonin:sodium symporter activity |
| Specific Function
| Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| SLC6A4 |
| Gene Sequence
|
>1893 bp
ATGGAGACCACCCCCTTAAATTCCCAGAAGGAGCTATCAGCGTATAAGGATGGAGAAGAT
TGTCAGGAAAATGGGGTTCTACAGAAGGGTGTCCCCGCCCCTGGGGATAAGGCAGAGTCC
GGCCAGATCTCCAACGGGTACTCAGCGGTTCCGAACCCTGGCGCAGGAGACGACACTCAG
CACTCCATCCCGGCTGCCACCACCGCCCTAGTGGCTGAGGTTCATCCAGCAGAGCGGGAG
ACCTGGGCCAAGAAGGTGGATTTCCTCCTCTCTGTCATTGGCTATGCTGTGGACCTGGGC
AACGTCTGGCGCTTTCCCTACATTTGTTACCAGAATGGAGGGGGGGCGTTCCTCCTTCCC
TACACTATCATGGCCATTTTTGGGGGGATCCCGCTCTTCTACATGGAGCTCGCACTGGGG
CAGTACCACCGAAATGGATGCATTTCGATATGGACAAAAATCTGCCCAATTTTCAAAGGG
ATAGGTTGCGCCATCTGCCTCATCGCCTTCTACATCGCCTCCTACTACAACACCATCATA
GCCTGGGCCCTCTACTACCTCATCTCCTCCTTCACGGAGCAGCTGCCCTGGACCAGCTGC
GAGAACTCCTGGAACACTGGCAACTGCACCAACTACTTCTCCGAGGATAACATCACCTGG
ACGCTCCACTCAACGTCCCCTGCAGAAGAATTTTACACGCGGCACGTCCTGCAGATCCAC
CGGTCGAAGGGGCTCCAGGACCTGGGGGGCCTCAGTTGGCAGCTTGTCCTGTGCATCATG
TTCATCTTCACTGTTATCTACTTTAGCATCTGGAAAGGCGTCAAAACATCTGGCAAGGTG
GTTTGGGTGACAGCCACCTTCCCTTACATCATTCTTTTGATCCTGCTGGTGAGGGGGGCC
ACCCTCCCTGGAGCCTGGAGGGGAGTTCTCTTCTATTTGAAACCCAACTGGCAGAAACTC
CTAGAGACGGGGGTGTGGGTGGATGCAGCCGCCCAGATCTTCTTCTCTCTCGGCCCTGGC
TTTGGGGTCCTACTGGCTTTTGCGAGCTACAACAAATTCCACAACAACTGTTACCAAGAC
GCCCTGGTGACCAGTGCAGTGAATTGCATGACGAGCTTCGTTTCAGGATTTGTCATCTTC
ACAGTGCTGGGGTATATGGCTGAGATGAGGAAAGAAGATGTGTCTGAGGTGGCCAAAGAT
GCAGGCCCCAGCCTCCTGTTCATCACATACGCAGAAGCCATAGCCAACATGCCAGCATCC
ACATTCTTTGCCATCGTCTTCTTCCTGATGTTAATCACCCTGGGCTTGGACAGCACGTTT
GCAGGCTTGGAGGGGGTGATCACAGCTGTGCTAGATGAGTTTCCACATGTCTGGGCCAAG
CGCCGGGAGTGGTTTGTGCTTGGCGTGGTCATTACCTGCTTCTTTGGATCTCTGGTCACC
TTGACTTTCGGCGGGGCCTATGTGGTGAAGCTGTTGGAGGAGTTCGCCACGGGACCTGCA
GTGCTCACCGTGGCCCTGATTGAAGCAGTTGCTGTGTTTTGGTTCTACGGCATCAATCAG
TTCTGCAGTGATGTGAAGGAAATGCTTGGTTTCAGCCCTGGATGGTTCTGGAAGATCTGC
TGGGTAGCCATCAGTCCTCTGTTTCTCCTGTTCATCATCTGCAGTTTTTTGATGAGCCCA
CCACAGCTACGACTTTTCCAGTATGATTATCCTCGGTGGAGCATCATCCTGGGTTACTGC
ATAGGAACCTCATCTTTCATCTGCATCCCCACATATATAACCTATCGGCTGATTGTCACT
CCAGGGACACTTAAGGAGCGTATTATTAAAGGTATCACGCCAGAAACACCGACAGCAATT
CCCTGTGGGGACATCCGCTTGAATGCTGTGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 630 |
| Molecular Weight
| 70036.0 |
| Theoretical pI
| 5.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 88-112
- 116-135
- 161-186
- 253-271
- 278-297
- 325-347
- 361-380
- 422-443
- 464-483
- 495-516
- 539-558
- 575-595
|
| Protein Sequence
|
>Sodium-dependent serotonin transporter
METTPLNSQKELSAYKDGEDCQENGVLQKGVPAPGDKAESGQISNGYSAVPNPGAGDDTQ
HSIPAATTALVAEVHPAERETWAKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWTKICPIFKGIGCAICLIAFYIASYYNTII
AWALYYLISSFTEQLPWTSCENSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGLSWQLVLCIMFIFTVIYFSIWKGVKTSGKVVWVTATFPYIILLILLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCYQD
ALVTSAVNCMTSFVSGFVIFTVLGYMAEMRKEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIVFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRREWFVLGVVITCFFGSLVT
LTFGGAYVVKLLEEFATGPAVLTVALIEAVAVFWFYGINQFCSDVKEMLGFSPGWFWKIC
WVAISPLFLLFIICSFLMSPPQLRLFQYDYPRWSIILGYCIGTSSFICIPTYITYRLIVT
PGTLKERIIKGITPETPTAIPCGDIRLNAV
|
| External Links |
|---|
| GenBank ID Protein
| AAD26262.1 |
| UniProtKB/Swiss-Prot ID
| Q9XT49 |
| UniProtKB/Swiss-Prot Entry Name
| SC6A4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF119122 |
| GeneCard ID
| SLC6A4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
