| Identification |
|---|
| BMDB Protein ID
| BMDBP02223 |
| Secondary Accession Numbers
| None |
| Name
| 5-hydroxytryptamine receptor 2A |
| Synonyms
|
Not Available
|
| Gene Name
| HTR2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor activity |
| Specific Function
| G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). |
| Pathways
|
- G-Protein Signaling Through Tubby Proteins
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| HTR2A |
| Gene Sequence
|
>1413 bp
ATGGATATTCTCTGTGAAGAAAACACTTCTTTGAGCTCAACTACGAACTCCTTAATGCAA
TTACATGCTGACACAAGGCTCTACAGTACTGACTTTAACTCCGGAGAAGGTAACACTTCG
AATGCATTTAACTGGACCGTGGACTCAGAAAATCGAACCAACCTTTCCTGTGAGGGCTGT
CTCTCACCACCCTGCTTCTCCTTACTTCATCTCCAGGAAAAGAACTGGTCTGCTCTGTTG
ACAGCGGTAGTGATTATACTAACCATTGCCGGAAACATACTCGTCATCATGGCAGTGTCC
CTAGAGAAAAAGCTGCAGAATGCCACCAACTATTTCCTGATGTCACTCGCCATAGCTGAT
ATGCTGCTGGGTTTCCTGGTCATGCCCGTGTCCACGTTAACCATCCTCTATGGGTACCGG
TGGCCTCTGCCCAGCAAGCTCTGCGCTGTTTGGATTTACCTGGATGTGCTCTTCTCCACG
GCCTCCATCATGCATCTGTGTGCTATCTCCCTGGACCGCTATGTTGCCATTCAGAACCCC
ATCCATCACAGCCGGTTCAACTCCAGAACTAAGGCATTTCTGAAAATAATTGCTGTTTGG
ACGATATCAGTGGGTATATCCATGCCAATACCAGTCTTTGGGCTCCAGGACGATTCCAAA
GTCTTTAAGGAAGGGAGTTGCTTACTCGCGGATGAGAACTTTGTCCTGATTGGCTCTTTC
GTGGCCTTTTTCATTCCCTTAACCATCATGGTGATCACCTACTTTCTCACCATCAAGTCG
CTCCAGAAAGAAGCCACTTTGTGTGTGAGTGATCCTGGAACACGGACCAAATTAGCTTCT
TTCAGCTTCCTGCCTCAGAGCTCCCTGTCTTCGGAAAAGCTCTTCCAGCGGTCCATCCAC
AGGGAGCCAGGCTCCTACGGCAGGAGGACTATGCAGTCCATCAGCAACGAGCAGAAGGCT
TGCAAGGTGCTGGGCATCGTCTTCTTCCTGTTTGTGGTGATGTGGTGCCCCTTCTTCATC
ACCAACATAATGGCTGTCATCTGCAAAGAGTCCTGCAACAGGGATGTCATCGAAGCCCTG
CTCAACGTGTTCGTTTGGATCGGTTACCTCTCCTCAGCAGTCAACCCGCTGGTGTATACA
CTGTTCAATAAGACCTATAGGTCTGCCTTTTCCAGGTATATTCAGTGTCAGTACAAGGAA
AATAAAAAACCATTGCAGTTAATTTTAGTGAACACTATCCCGGCCTTGGCTTATAAGTCC
AGTCAACTCCAAATGGGACCTAAAAAGAATTCGAAGAAAGATGACAAGACGACAGATAAT
GACTGCACTATGGTTGCTCTAGGAAAAGAGCATCCCGAAGATGCTCCTGCAGACAGTAGC
AACACAGTGAACGAAAAGGTTAGCTGTGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 470 |
| Molecular Weight
| 52571.0 |
| Theoretical pI
| 8.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 76-99
- 111-133
- 149-171
- 192-215
- 234-254
- 324-345
- 362-383
|
| Protein Sequence
|
>5-hydroxytryptamine receptor 2A
MDILCEENTSLSSTTNSLMQLHADTRLYSTDFNSGEGNTSNAFNWTVDSENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSTLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADENFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRTKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNRDVIEAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQMGPKKNSKKDDKTTDNDCTMVALGKEHPEDAPADSSNTVNEKVSCV
|
| External Links |
|---|
| GenBank ID Protein
| BAD12238.1 |
| UniProtKB/Swiss-Prot ID
| Q75Z89 |
| UniProtKB/Swiss-Prot Entry Name
| 5HT2A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB119637 |
| GeneCard ID
| HTR2A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
