| Identification |
|---|
| BMDB Protein ID
| BMDBP02240 |
| Secondary Accession Numbers
| None |
| Name
| N-arachidonyl glycine receptor |
| Synonyms
|
Not Available
|
| Gene Name
| GPR18 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in purinergic nucleotide receptor activity, G- |
| Specific Function
| Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated by plant-derived and synthetic cannabinoid agonists. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8 alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant. Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure. Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| GPR18 |
| Gene Sequence
|
>999 bp
ATGACCACCCCTCACAGTCAAGCTCAACCTGGCCTTCCTATCGACCCACATCCAGATGAA
TACAAGGTGGCAGCCCTCGTCTTCTACAGCTGCATCTTCATCATTGGATTATTTGTCAAC
GTCACCGCCTTATGGGTTTTCAGTTGCACCACCAAGAAGAGAACCACTGTGACCGTCTAT
ATGATGAACGTGGCGCTACTGGACTTGGTGTTTATAATGAGCTTACCCTTTCGGATGCTT
TACTACGCAAAAGGTGAATGGCCTTTTGGAGAGTACTTTTGCCGGATTCTTGGGGCTCTC
ACAGTGTTTTACCCGAGTATTGCTCTGTGGCTTCTCGCCTTTATTAGTGCTGACAGATAC
ATGGCCATCGTACAGCCGAAATATGCCAAGGAACTTAAAAACACGTGCAAGGCCGTGATG
GCGTGTGTGGGCGTCTGGATAATGACCCTGACCACCACCATCCCACTCCTGCTGCTCTAT
GAAGACCCAGACACAGCCTCCTCCACCCCCCCTACCTGCCTCAAGATTTCTGACATCATT
TACTTAAAAGCTATTAATGCGCTGAACTTCACTCGACTGATATTTTTTTTCTTGATTCCT
CTGTTCATCATGATTGGGTGCTACTTGGTCATTATCCATAGTCTCCTTCATGGTAAGACC
TCTAAGCTGAAGCCAAAGGTCAAGGAGAAGTCGATCCGGATCATCATCACGCTGATGGTG
CAGGTGCTGGTCTGCTTCATGCCCTTCCACATTTGCTTTGCTTTCCTGATGCTGGGAGGG
GATGAGAACAGCTACAACCCCTGGGGAGCCTTCACCACCTTCCTCATGAACCTCAGCACT
TGTCTGGACGTGATTCTCTACTACATCGTTTCGAAACAATTTCAGGCTCGAGTCATTAGC
GTCATGCTGTACCGTAATTACCTTCGGAGCGTGCGCAGAAAGAGCTTCCGCTCAGGTAGC
TTACGGTCACTAAGCAACATAAACAGTGAAATGTTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 332 |
| Molecular Weight
| 37949.0 |
| Theoretical pI
| 9.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 27-47
- 57-77
- 96-116
- 139-159
- 193-213
- 234-254
- 270-290
|
| Protein Sequence
|
>N-arachidonyl glycine receptor
MTTPHSQAQPGLPIDPHPDEYKVAALVFYSCIFIIGLFVNVTALWVFSCTTKKRTTVTVY
MMNVALLDLVFIMSLPFRMLYYAKGEWPFGEYFCRILGALTVFYPSIALWLLAFISADRY
MAIVQPKYAKELKNTCKAVMACVGVWIMTLTTTIPLLLLYEDPDTASSTPPTCLKISDII
YLKAINALNFTRLIFFFLIPLFIMIGCYLVIIHSLLHGKTSKLKPKVKEKSIRIIITLMV
QVLVCFMPFHICFAFLMLGGDENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVIS
VMLYRNYLRSVRRKSFRSGSLRSLSNINSEML
|
| External Links |
|---|
| GenBank ID Protein
| AAI02422.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0E9 |
| UniProtKB/Swiss-Prot Entry Name
| GPR18_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC102421 |
| GeneCard ID
| GPR18 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
