1.0 2018-05-07 22:30:43 UTC 2020-05-20 21:03:15 UTC BMDBP02249 BMDBP03109 Enzyme HMGCR Lipid transport and metabolism Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. (R)-mevalonate biosynthesis (R)-mevalonate from acetyl-CoA: step 3/3 Metabolic intermediate biosynthesis BMDB0000221 NADPH BMDB0001375 3-Hydroxy-3-methylglutaryl-CoA BMDB0000227 Mevalonic acid BMDB0000217 NADP BMDB0001423 Coenzyme A 10 >2667 bp ATGCTGTCAAGACTTTTCCGAATGCATGGCCTCTTCGTGGCCTCCCATCCCTGGGAAGTC ATAGTGGGGACAGTGACGCTGACCATCTGCATGATGTCCATGAACATGTTTACTGGCAAC AATAAGATCTGCGGTTGGAATTATGAATGTCCGAAGTTGGAAGAGGATGTTTTGAGCAGC GACATCATAATTCTGACAATAACACGATGCATAGCAATATTGTATATTTACTTCCAGTTC CAGAATTTACGCCAACTTGGATCAAAATATATTTTGGGTATTGCTGGACTCTTCACAATT TTCTCCAGTTTCGTATTCAGTACAGTTGTCATTCATTTCTTAGATAAAGAATTGACAGGT TTGAATGAAGCTTTGCCCTTTTTCCTGCTGCTGGTCGACCTTTCTAGAGCAAGTGCGCTA GCCAAGTTCGCCCTCAGTTCTAACTCACAGGATGAAGTGAGGGAGAACATTGCTCGTGGG ATGGCGATTTTAGGTCCCACCTTCACCCTGGATGCTCTTGTAGAATGTCTTGTGATTGGA GTTGGTACCATGTCAGGGGTGCGTCAGCTCGAAATCATGTGCTGCTTTGGCTGCATGTCG GTTCTCGCCAACTACTTTGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTTCTG GAGCTTTCTCGGGAAAGCCGCGAGGGCCGTCCAATCTGGCAGCTCAGCCATTTTGCCCGA GTCTTAGAAGAAGAAGAAAATAAGCCAAATCCTGTTACTCAGAGGGTTAAGATGATTATG TCTCTAGGCTTGGTTCTTGTTCACGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA AACAGCACAGCAGACAATTCTAAGGTCTCTTTAGGACTGGATGAAAATGTGTCCAAGAGA ATTGAACCGAGTGTTTCCCTCTGGCAATTTTATCTCTCTAAAATGATCAGCATGGATATT GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA CAAGCAGAGACAGAATCTACACTCTCGTTAAAAAATCCTATCACATCTCCTGTAGTGACC CAAAAGAAAATCACAGACGATTGTTGTAGACGTGACCCTGTACTGGTCAGAAATGACCAG AAATTCCATGCAATGGAGGAGGAGACCAGGAAAAACAGAGAAAGAAAAGTTGAGGTTATA AAACCCTTACTGGCAGAAAATGACACCTCACACAGAGCCACATTCGTGGTGGGGAACTCC TCCTTACTCGGTACTTCGCTGGAACTAGAGACACAGGAGCCTGAAATGGAACTCCCTGTG GAGCCTCGGCCTAATGAAGAGTGTCTGCAGATTCTTGAGAATGCAGAGAAAGGTGCAAAA TTCCTTAGTGATGCTGAGATCATCCAGTTGGTCAATGCAAAGCATATCCCAGCTTACAAA TTGGAAACTCTGATGGAAACCCATGAGCGAGGTGTATCTATTCGCCGACAGCTACTTTCC AAAAAACTTCCAGAGCCTTCTTCTCTCCAGTATCTACCTTACAGGGACTATAATTACTCC TTGGTGATGGGAGCTTGCTGTGAGAACGTTATTGGATATATGCCCATCCCTGTTGGAGTG GCAGGACCTCTGTGCTTGGATGGAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGC TGTCTTGTGGCCAGCACTAATAGAGGCTGCAGAGCAATAGGCCTTGGTGGAGGTGCCAGC AGCCGAGTCCTTGCAGACGGGATGACTCGTGGCCCAGTGGTGCGTTTTCCCCGTGCTTGT GACTCTGCAGAAGTGAAGGCCTGGCTTGAGACGCCTGAAGGGTTCACAGTGATAAAGGAA GCCTTCGACAGCACCAGCAGGGTTGCACGTCTACAGAAACTGCATATGAGTGTGGCCGGA CGCAACCTTTACATCCGTTTTCAGTCCAGGTCAGGTGATGCCATGGGGATGAACATGATT TCAAAGGGTACAGAGAAAGCACTGTCCAAACTTCAGGAGTATTTCCCCGAAATGCAGATT TTGGCCGTCAGTGGGAACTATTGTACAGACAAGAAACCTGCGGCCATCAACTGGATAGAG GGACGAGGAAAGTCTGTGGTCTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA TTAAAGACTACAACAGAGGCTATGATTGAGGTCAACATTAATAAAAACCTGGTGGGCTCT GCCATGGCTGGGAGCATCGGCGGCTACAACGCCCACGCAGCGAACATTGTAACTGCCATC TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCGAACTGTATTACTTTA ATGGAAGCAAGCGGTCCCACGAACGAAGACCTGTACATCAGCTGCACCATGCCATCTATA GAAATAGGAACCGTGGGCGGGGGCACCAACTTGCTGCCTCAGCAGGCCTGCCTGCAGATG CTAGGCGTCCAAGGAGCATGCAGAGACAACCCCGGGGAAAATGCGCGGCAGCTGGCCCGA ATCGTGTGCGGCACGGTGATGGCTGGGGAGCTGTCTCTGATGGCAGCACTGGCAGCAGGC CATCTGGTCAGAAGTCACATGATTCACAACAGGTCAAAGATAAATTTGCAAGACCTCCAA GGAACTTGCACTAAGAAGGCAGCTTGA 888 97727.0 6.66 11-31 58-78 91-111 125-145 161-181 192-212 320-340 841-861 None >HMGCR protein MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKLEEDVLSS DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG LNEALPFFLLLVDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKR IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT QKKITDDCCRRDPVLVRNDQKFHAMEEETRKNRERKVEVIKPLLAENDTSHRATFVVGNS SLLGTSLELETQEPEMELPVEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYK LETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV AGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRFPRAC DSAEVKAWLETPEGFTVIKEAFDSTSRVARLQKLHMSVAGRNLYIRFQSRSGDAMGMNMI SKGTEKALSKLQEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACRDNPGENARQLAR IVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA AAI53263.1 A7Z064 HMDH_BOVIN 1HWL DAAA02027738 HMGCR