| Identification |
|---|
| BMDB Protein ID
| BMDBP02320 |
| Secondary Accession Numbers
| None |
| Name
| Polycomb complex protein BMI-1 |
| Synonyms
|
Not Available
|
| Gene Name
| BMI1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| BMI1 |
| Gene Sequence
|
>981 bp
ATGCATCGAACAACCAGAATCAAGATCACTGAGCTAAATCCCCACCTAATGTGTGTTCTT
TGTGGAGGGTACTTCATTGATGCCACAACCATAATAGAATGTCTACATTCCTTCTGTAAA
ACGTGTATTGTGCGTTACCTGGAGACCAGCAAGTATTGTCCTATCTGTGATGTCCAAGTT
CACAAAACCAGACCACTACTGAATATAAGGTCAGATAAAACTCTTCAAGATATTGTATAC
AAATTAGTTCCAGGGCTTTTCAAAAATGAAATGAAGAGAAGAAGGGATTTTTATGCCGCT
CATCCTTCAGCTGATGCTGCCAATGGCTCTAATGAAGACAGAGGAGAAGTGGCTGATGAA
GATAAGAGAATTATAACTGATGATGAGATAATAAGTTTATCCATTGAATTCTTTGACCAG
AACAGATTGGATCGGAAAATAAACAAGGACAAAGAGAAATCTAAGGAGGAGGTGAATGAT
AAAAGATATTTACGATGCCCAGCAGCAATGACTGTAATGCACCTAAGAAAGTTTCTCAGA
AGTAAAATGGACATACCTAATACTTTCCAGATTGATGTCATGTATGAAGAGGAACCTTTA
AAAGATTACTATACACTAATGGATATTGCCTACATTTATACCTGGAGAAGGAATGGCCCA
CTTCCTTTGAAATACAGAGTTCGACCTACTTGTAAAAGAATGAAGATCAGTCATCAGAGA
GATGGACTGACTAACACTGGAGAACTGGAAAGTGACTCTGGGAGTGACAAGGCCAACAGC
CCAGCAGGAGGCATCCCCTCCACCTCTTCCTGTTTGCCCAGTCCCAGCACTCCAGTCCAG
TCTCCTCATCCTCAGTTTCCTCACATTTCCAGTACTATGAATGGAACCAGCAGCAGCCCC
AGCGGTAACCACCAATCTTCCTTTGCCAATAGACCTCGAAAATCATCAGTAAATGGGTCG
TCAGCAACTTCATCTGGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 326 |
| Molecular Weight
| 36966.0 |
| Theoretical pI
| 8.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Polycomb complex protein BMI-1
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQV
HKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADE
DKRIITDDEIISLSIEFFDQNRLDRKINKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLR
SKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQR
DGLTNTGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSSSP
SGNHQSSFANRPRKSSVNGSSATSSG
|
| External Links |
|---|
| GenBank ID Protein
| AAI09872.1 |
| UniProtKB/Swiss-Prot ID
| Q32KX7 |
| UniProtKB/Swiss-Prot Entry Name
| BMI1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109871 |
| GeneCard ID
| BMI1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
