| Identification |
|---|
| BMDB Protein ID
| BMDBP02332 |
| Secondary Accession Numbers
| None |
| Name
| Neurotrophin receptor-interacting factor homolog |
| Synonyms
|
Not Available
|
| Gene Name
| ZNF274 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transcription factor activity |
| Specific Function
| Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| ZNF274 |
| Gene Sequence
|
>1863 bp
ATGGCCTCCGGGCTTCCGACGGATTGGTTCCGTGAACCAGTGACCTTTGAAGATGTGGCC
TTGGGTTTTACCCCAGATGAGTGGGGAAAGCTGGACCTCGAACAGAAGTCCCTGTACAGG
GAGGTGATGCTGGAGAACTACAGGAACCTGGTCTCAGTGGAACATCAGCTTTCCAAGCCA
GATGTGGTATCTCAGTTAGAGGAAGAGGAAGAGCTGTGGTCGGTGGAGAGAGGAATTCCT
CAAGACACCTTTTCAGAGTGTCCTGAGGCTCAGTTGGAACCTCAGTTGGATCCTTTTCCT
GCTGGGAATCCCCTGATGAACATCGAGGTGGTTGAAGTCCTCACCCTGAACCAGGAGGTG
GCTGTTCCCCGGAATGCCCAGATCCGGGCTCTGTATGCTGAAGATGAGGGCCTGAGCCCA
GAGGTTCTCAGGGAGCCCCCTCAACATCTGGATAAGCCTACGGCTGATCCTGAGATGGCT
CGGCAGAGGTTCCGGGGTTTCCACTTTGAGGAGGTGGCTGGTCCCCGCGAGGCGCTGGCC
CAACTCCGGGAGCTCTGCTGCCAGTGGCTGCGGCCCGAGGCGCACTCCAAGGACCAGATG
CTGGAGCTGCTGGTGCTGGAGCAGTTCCTGGGCGCACTGCCTGAGAAGCTGCGGCTATGG
GTGGAGTCGCAGCACCCAGTGGACTGCCGGCAGGCAGTGGCCCTGGTGGAGGACGTGACC
TGGATCTCTGAGGAGGAAACACTGCCCACCCAGGGCGCCCCCGGCACTCTCCCTCCCGCG
GCTCAGCAGGACACAGCTACCTGGCCCGTGAAGGCGCTGCCTGAGGATCCAGTGACCTTC
CTGGACGTGGCTGTGGACTTCAGCACGGAGGAGTGGGGGCTGCTGGACCCAACACAGCGG
ACTGAGTACCACGACGTGATGCTGGAGACCTTCGGACACCTGGTGTCTGTGGGGTGGGAG
ACGACCCTGGACAGCAAGCAGTTAACGCCACAGCCTGGACCTCCTGAGGAGGGGCCCGCC
TGCCCCCTGAAGGAGGAGGAGGGGTCCTCGGCGGATGACGCCCGGCCCTCCACCTCCGGA
GAGGCTCTGGAGGCCGGGGCCCCGGGAGTCTGGGACACAGCGCTGAAACCGGTGACACTC
GCTTCGGAAAATACCCTCCCCCCGCAGCCGCCCGGGGACAGCCCCCAACCCCAGGCGAGC
ACAGGCCCGGACCGCGGCCGCGTCTCCCTTCAGAAAGCTGTTCCTAGAAAGCGCTTGCGC
AAGCGCGACCCCTGGCTTAAAAGGGGGACACGCGGCGCATGCGTAAAGCTTCCTCCAAAG
CGCGGCGGCGCCGGGAAGGCTGTGGAGAGCGGCGGCGACGGGGGCAGGAGGCCCTGCGCC
CGGAACGCCCCGCAGATCACCTTCACGCGAATTCACAAAGGGAGCCAGGTGTGCCGGTGC
AGCGAATGCGGGAAGACGTTCCGGAATCCCAGGTACTTCTCGGTGCACAAGAAGATCCAC
ACGGGAGAGAAGCCCTATGTGTGTCGGGACTGCGGGAAGGCGTTCGTGCAGAGCTCCTCC
CTCAGGCAGCACCAGAGGGTTCACACTGGGGAGAGACCCTTCGTGTGTCACGAGTGCGGG
AGGACTTTCAACGACCGCTCGGCCATCTCCCAGCACCTGCGGACCCACACCGGGGCCAAG
CCCTACCCGTGTCCGGACTGCGGCAAAGCCTTCCGCCAGAGCTCCCATCTCATCCGGCAT
CAGAGGACTCACACCGGCGAGCGCCCCTACTCCTGTAGCAAGTGCGGAAAGGCCTTCACG
CAGAGCTCGCACCTGATAGGGCACCAGAAAACGCACAGCAGGGTGAAATGCAAGAAGAAA
TAG
|
| Protein Properties |
|---|
| Number of Residues
| 620 |
| Molecular Weight
| 69254.0 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ZNF274 protein
MASGLPTDWFREPVTFEDVALGFTPDEWGKLDLEQKSLYREVMLENYRNLVSVEHQLSKP
DVVSQLEEEEELWSVERGIPQDTFSECPEAQLEPQLDPFPAGNPLMNIEVVEVLTLNQEV
AVPRNAQIRALYAEDEGLSPEVLREPPQHLDKPTADPEMARQRFRGFHFEEVAGPREALA
QLRELCCQWLRPEAHSKDQMLELLVLEQFLGALPEKLRLWVESQHPVDCRQAVALVEDVT
WISEEETLPTQGAPGTLPPAAQQDTATWPVKALPEDPVTFLDVAVDFSTEEWGLLDPTQR
TEYHDVMLETFGHLVSVGWETTLDSKQLTPQPGPPEEGPACPLKEEEGSSADDARPSTSG
EALEAGAPGVWDTALKPVTLASENTLPPQPPGDSPQPQASTGPDRGRVSLQKAVPRKRLR
KRDPWLKRGTRGACVKLPPKRGGAGKAVESGGDGGRRPCARNAPQITFTRIHKGSQVCRC
SECGKTFRNPRYFSVHKKIHTGEKPYVCRDCGKAFVQSSSLRQHQRVHTGERPFVCHECG
RTFNDRSAISQHLRTHTGAKPYPCPDCGKAFRQSSHLIRHQRTHTGERPYSCSKCGKAFT
QSSHLIGHQKTHSRVKCKKK
|
| External Links |
|---|
| GenBank ID Protein
| AAI49475.1 |
| UniProtKB/Swiss-Prot ID
| A6QPT6 |
| UniProtKB/Swiss-Prot Entry Name
| ZN274_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC149474 |
| GeneCard ID
| ZNF274 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
