| Identification |
|---|
| BMDB Protein ID
| BMDBP02367 |
| Secondary Accession Numbers
| None |
| Name
| Transcription factor IIIB 50 kDa subunit |
| Synonyms
|
Not Available
|
| Gene Name
| BRF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Translation, ribosomal structure and biogenesis |
| Specific Function
| General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| BRF2 |
| Gene Sequence
|
>1266 bp
ATGCCGGGTAGAGGCCGCTGTCCCGATTGCGGCTCCGCTGAGCTCGTGGAAGACTCGCAC
TATTCCCAGAACCAGCTGGTGTGCTCCGACTGCGGCTGCGTGGTCACCGAGGGCGTTCTT
ACGACCACCTTCAGTGACGAGGGCAACCTCCGAGAAGTAACATATTCTCGAAGCACCGGG
GAAAACGAACAAGTTAGTCGAAGCCAGCAACGAGGTCTTCGTCGAGTGAGAGACCTCTGT
CGAGTGCTGCAGCTGCCGCCAACATTTGAGGACACGGCAGTTGCCTACTACCAACAGGCG
CACCAGCTCGCTGGCATCCGCACGGCCAGGCTGCAGAAGAAGGAGGTGCTGGCTGGTTGC
TGCGTCCTAATCACCTGCCGGCAGCGTAACTGGCCCCTGACCATGGGGACCATCTGCACC
CTGCTGTATGCAGATTTGGATGTGTTTTCTGGAACCTACATGCAGATAGTGAAGCTCCTG
GGGCTGGATGTGCCATCTCTGTGCTTGGTGGACCTGGTGAAGACCTACTGTAGCAGCTTC
AAGCTGTTTGAAGCCTCCCCATCTGTGCCAGCCAAGTACGTGGAAGACAAGGAGAAGATG
CTGTCGCGAACACTGCAGTTGGTGGAGCTGGCTGATGAAACGTGGCTGGTGACCGGGCGG
CACCCCTTGCCCGTCATCACCGCCGCCACTTTCCTGGCGTGGCAGTCCCTGCAGCCTTCA
GATCGGCTGACCTGTTCCCTTGCCCGATTTTGTAAATTGGCGAACGTGGACCTGCCCTAC
CCCGCTTCCTCCCGCCTGCAGGAGCTGCTGGCTGTGCTGCTGCGGATGGCTGAGCAGCTG
GCCTGGTTGCAGGTTCTGAAGCTTGACAAACGGTCTGTGGTCAAGCACATCGGCGACCTT
CTCCAGCACCGCCACATGCTGGTCCGCAAGGCCTTTCGGGATGGAACAGCCGAGATGGAT
GCCGGGGAGAAGGAGCTGCAGGGCCAGGGGCAGGGGCAAGCACTGGGAGACGAGGATGTG
GGGAGTAGCTCTTTAGAGCTGCCTGCGGGCAAGCGGCCCTCCAGCCCCGCTCTCCTCCTC
CCACCCTGCATGTTGAAGCCCCCAAAACGAGTCTGTCCCGCCCCCCCTGTCTCCATGGTC
ACTGGAGACGAGGACATTTCTGATAGTGAAATCGAGCAGTATTTGCGTACCCCTCAGGAA
GTTAGGGACTTCCAGAAGGCCCAGGCAGCTAGACAGGCCGCCCAGGGTACTCCGAACCCT
CCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 421 |
| Molecular Weight
| 46591.0 |
| Theoretical pI
| 6.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Transcription factor IIIB 50 kDa subunit
MPGRGRCPDCGSAELVEDSHYSQNQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTG
ENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAHQLAGIRTARLQKKEVLAGC
CVLITCRQRNWPLTMGTICTLLYADLDVFSGTYMQIVKLLGLDVPSLCLVDLVKTYCSSF
KLFEASPSVPAKYVEDKEKMLSRTLQLVELADETWLVTGRHPLPVITAATFLAWQSLRPS
DRLTCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLQVLKLDKRSVVKHIGDL
LQHRHMLVRKAFRDGTAEMDAGEKELQGQGQGQGLGDEDVGSSSLELPAGKRPSSPALLL
PPCMLKPPKRVCPAPPVSMVTGDEDISDSEIEQYLRTPQEVRDFQKAQAARQAAQGTPNP
P
|
| External Links |
|---|
| GenBank ID Protein
| AAX08668.1 |
| UniProtKB/Swiss-Prot ID
| Q29S07 |
| UniProtKB/Swiss-Prot Entry Name
| BRF2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020651 |
| GeneCard ID
| BRF2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
