| Identification |
|---|
| BMDB Protein ID
| BMDBP02392 |
| Secondary Accession Numbers
| None |
| Name
| Transcription factor COE2 |
| Synonyms
|
Not Available
|
| Gene Name
| EBF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| EBF2 |
| Gene Sequence
|
>1728 bp
ATGTTTGGGATCCAAGATACTTTAGGAAGAGGACCAGCTCTAAAAGAGAAATCGCTGGGC
GCCGAGATGGATTCGGTCAGGTCCTGGGTCCGAAACGTCGGCGTGGTGGACGCCAATGTC
GCGGCGCAGAGCGGCGTAGCCCTGTCCCGGGCCCACTTTGAGAAACAGCCTCCTTCCAAC
TTGAGGAAATCCAACTTCTTTCACTTCGTCCTGGCGCTCTACGACAGGCAGGGGCAGCCG
GTGGAGATCGAGCGCACCGCCTTCGTAGACTTTGTGGAGAACGACAAAGAACAAGGCAAC
GAGAAGACCAATAACGGCACCCACTACAAGTTACAGCTTCTCTACAGCAACGGTGTCCGC
ACGGAGCAGGACCTGTACGTCAGACTCATTGACTCAGTCACCAAGCAGCCCATAGCTTAC
GAGGGACAAAATAAGAATCCGGAAATGTGCCGAGTTCTCCTGACACACGAAGTGATGTGC
AGTCGGTGTTGCGAAAAGAAAAGTTGTGGCAACCGAAATGAGACTCCTTCAGACCCTGTC
ATCATCGACAGATTCTTTTTAAAATTTTTCCTCAAGTGCAATCAGAATTGTTTGAAAACA
GCAGGAAACCCAAGGGACATGAGAAGGTTTCAGGTCGTATTGTCAACAACAGTGAATGTG
GATGGACATGTGCTGGCTGTTTCTGACAACATGTTTGTTCACAACAACTCGAAGCATGGA
CGGAGAGCCAGAAGGCTGGACCCATCGGAAGCAACTCCATGCATCAAAGCCATTAGCCCA
AGTGAAGGCTGGACCACTGGAGGAGCCATGGTCATCATTATTGGGGACAACTTCTTTGAT
GGCCTCCAAGTGGTGTTTGGGACCATGCTTGTATGGAGTGAGCTAATAACTCCTCATGCC
ATCAGAGTGCAGACTCCTCCTCGGCACATCCCTGGGGTCGTAGAAGTGACATTGTCTTAC
AAATCCAAACAGTTCTGCAAAGGAGCTCCAGGGAGGTTCATTTACACAGCATTAAATGAA
CCCACCATAGACTATGGCTTTCAGAGACTGCAGAAGGTCATCCCAAGACATCCTGGAGAT
CCTGAGAGATTAGCTAAGGAAATGCTATTGAAAAGAGCGGCAGATCTGGTGGAGGCGCTC
TATGGAACACCACACAATAACCAGGACATCATTTTGAAGCGAGCCGCGGACATCGCTGAA
GCCCTCTACAGTGTCCCCAGGAATCCCAGCCAGATCCCAGCTCTCTCCAGCTCCCCGGCT
CACAGTGGCATGATGGGCATCAATTCCTATGGCAGCCAGCTCGGGGTCAGCATCTCAGAG
TCAACACAGGGAAACAATCAAGGATACATCCGCAACACGAGCAGCATCTCTCCACGGGGC
TATTCTTCCAGCTCCACCCCCCAGCAGTCTAACTACAGCACCTCCAGTAACAGCATGAAT
GGCTACAGCAACGTCCCCATGGCCAACCTGGGTGTTCCAGGGTCACCGGGATTTCTCAAC
GGCTCCCCCACCGGCTCCCCTTATGGAATCATGTCATCAAGTCCCACTGTTGGATCTTCC
AGCACATCCTCCATCCTCCCGTTTTCCTCTTCAGTTTTTCCTGCTGTCAAACAGAAGAGT
GCCTTTGCCCCTGTCATCAGGCCCCAAGGCTCCCCTTCGCCTGCCTGCTCCAGTGGCAAT
GGAAACGGATTCAGAGCCATGACTGGACTTGTCGTGCCCCCGATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 575 |
| Molecular Weight
| 62620.0 |
| Theoretical pI
| 9.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transcription factor COE2
MFGIQDTLGRGPALKEKSLGAEMDSVRSWVRNVGVVDANVAAQSGVALSRAHFEKQPPSN
LRKSNFFHFVLALYDRQGQPVEIERTAFVDFVENDKEQGNEKTNNGTHYKLQLLYSNGVR
TEQDLYVRLIDSVTKQPIAYEGQNKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPV
IIDRFFLKFFLKCNQNCLKTAGNPRDMRRFQVVLSTTVNVDGHVLAVSDNMFVHNNSKHG
RRARRLDPSEATPCIKAISPSEGWTTGGAMVIIIGDNFFDGLQVVFGTMLVWSELITPHA
IRVQTPPRHIPGVVEVTLSYKSKQFCKGAPGRFIYTALNEPTIDYGFQRLQKVIPRHPGD
PERLAKEMLLKRAADLVEALYGTPHNNQDIILKRAADIAEALYSVPRNPSQIPALSSSPA
HSGMMGINSYGSQLGVSISESTQGNNQGYIRNTSSISPRGYSSSSTPQQSNYSTSSNSMN
GYSNVPMANLGVPGSPGFLNGSPTGSPYGIMSSSPTVGSSSTSSILPFSSSVFPAVKQKS
AFAPVIRPQGSPSPACSSGNGNGFRAMTGLVVPPM
|
| External Links |
|---|
| GenBank ID Protein
| AAI23681.1 |
| UniProtKB/Swiss-Prot ID
| Q08DL5 |
| UniProtKB/Swiss-Prot Entry Name
| COE2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123680 |
| GeneCard ID
| EBF2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
