| Identification |
|---|
| BMDB Protein ID
| BMDBP02466 |
| Secondary Accession Numbers
| None |
| Name
| Cysteine and glycine-rich protein 3 |
| Synonyms
|
Not Available
|
| Gene Name
| CSRP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| CSRP3 |
| Gene Sequence
|
>585 bp
ATGCCAAACTGGGGTGGAGGAGCGAAATGCGGAGCCTGCGAAAAGACCGTCTACCACGCA
GAAGAAATCCAGTGCAATGGGAGGAGTTTCCACAAGACCTGTTTCCACTGCATGGCCTGC
AGGAAGGCACTGGACAGCACCACGGTGGCAGCTCACGAGTCAGAGATCTACTGTAAGGTC
TGCTACGGGCGCCGGTATGGCCCCAAAGGGATCGGGTATGGACAAGGCGCTGGCTGCCTC
AGCACGGACACAGGCGAACACCTGGGACTCCAGTTCCAACAGTCCCCAAAGCAGGCACGT
TCAGCCACCACCAGCAGCAACCCTTCCAAGTTTGCGAAGTTTGGAGAATCGGAGAAGTGC
CCTCGATGCGGAAAGTCGGTCTATGCTGCTGAGAAGGTGATGGGAGGTGGTAAGCCTTGG
CACAAGACCTGTTTTCGCTGCGCCATCTGTGGGAAGAGTCTAGAGTCCACAAACGTCACT
GACAAAGATGGGGAACTTTACTGCAAAGTGTGCTATGCCAAAAACTTCGGCCCTACAGGT
ATTGGGTTTGGGGGCCTTACACACCAAGTGGAAAAGAAAGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 194 |
| Molecular Weight
| 20953.0 |
| Theoretical pI
| 8.63 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cysteine and glycine-rich protein 3
MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKV
CYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKQARSATTSSNPSKFAKFGESEKC
PRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTG
IGFGGLTHQVEKKD
|
| External Links |
|---|
| GenBank ID Protein
| AAY45897.1 |
| UniProtKB/Swiss-Prot ID
| Q4U0T9 |
| UniProtKB/Swiss-Prot Entry Name
| CSRP3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ022067 |
| GeneCard ID
| CSRP3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
