| Identification |
|---|
| BMDB Protein ID
| BMDBP02526 |
| Secondary Accession Numbers
| None |
| Name
| SprT-like domain-containing protein Spartan |
| Synonyms
|
Not Available
|
| Gene Name
| SPRTN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| SPRTN |
| Gene Sequence
|
>1464 bp
ATGGATGAGGACCTGGTTTTGGCACTACAGCTTCAGGAGGAGTGGAACTTGCAGGTCTCG
GAGCGCGAACCGGCCCAGGAGCCCCTGTCTCTGGTGGACGCGTCTTGGGAGTTGGTGGAC
CCTACCCCTGACTTACAGGGCCTGTTTGTTCTGTTCAACGACCGTTTCTTCTGGGGCCAA
CTGGAGGCGGTCGAGGTGAAGTGGAGCGTGCGGATGACGCTGTGTGCTGGGATATGCAGC
TATGAAGGGAGGGGTGGAATGTGTTCCATCCGTCTCAGTGAACCCCTTTTAAAGCTGAGA
CCAAGAAAAGATCTTGTGGAGACCCTCTTGCATGAAATGATACATGCCTATTTATTTGTC
ACTAATAATGATAAAGATCGGGAAGGGCATGGTCCAGAGTTTTGTAAGCATATGCATCGC
ATCAATCGCCTGACAGGAGCCAATATAACGGTGTACCATACTTTCCATGACGAGGTAGAC
GAGTACCGTCGACACTGGTGGCGCTGCAACGGGCCGTGTCAGAACAGTAAGCCGTATTAC
GGCTATGTGAAGCGTGCCACCAACAGGGCACCCTCCGCCCATGACTACTGGTGGGCTGAA
CACCAGAAAACCTGTGGAGGCACTTACATCAAAATCAAGGAACCAGAGAACTACTCAAAA
AAGGGCAAAGGAAAGACAAAACTGAGAAAGCAGCCAGTATCAGAAGCAGAGAATAAAGAC
AAACCGAACAGAGGGGAGAAACAGCTGTTAATCCCCTTTACCGGGAAAGGTTATGTCCTA
GGGGAAACCAGCAATTTTTCATCTGGGAAATGTATCACTTCACATGCTATTAATGAAAGC
CAAGAGCCTTTAAGTCAAGACCATTCAGCAAATGCCCTGAGACCTCATTCTAAAACTGAG
GTGAAATTTGAACAGAATGGTCCAAGTAAAAAGACTTCTGTAGCATCCCCTGTTCTCAGT
ACCAGTCATCAGAATGTCTTAAGCAACTACTTCTCTAAAGTGTCCGTTGCCAGCAGCAAG
GCTTTCAGAAGTGTGAGTGGGTCTCCAGTGAAGAGCCTCACAGTGGGCGACAGCACTACA
AAGTCGGTCTCTGCCGGTTCTCAAAGGAGGGTTACATCTTCTAGGACATCTCTAAGAAAT
TCCTTAAAAGCCATGGAATCGACATATGTCACTGTGCCCCAGGATGCAGGTGGGCCTGAA
GGTAAACTCCCAAGTAAACGACCCAGGATAGAAGACAAGACTTTTTTTGACCTCTTTTTT
ATCAAGAAGGAGCAAGCGCAGAGTGGTGGTGGTGATGTGACGAGTAGTTCGCATCCTCCA
GCTGCAGCGCAGAGTCCCAGCGGTGCATCCGGTCAGAGCAGGGTGGTGCACTGTCCCGTG
TGTCAGGACGAGGTTTCGGAGACACAGATTAATGAGCACTTGGACTGGTGCCTTGAACGT
GATAGCACCCAAGTCAAAAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 487 |
| Molecular Weight
| 54521.0 |
| Theoretical pI
| 8.35 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Zinc finger RAD18 domain-containing protein C1orf124 homolog
MDEDLVLALQLQEEWNLQVSEREPAQEPLSLVDASWELVDPTPDLQGLFVLFNDRFFWGQ
LEAVEVKWSVRMTLCAGICSYEGRGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFV
TNNDKDREGHGPEFCKHMHRINRLTGANITVYHTFHDEVDEYRRHWWRCNGPCQNSKPYY
GYVKRATNRAPSAHDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKTKLRKQPVSEAENKD
KPNRGEKQLLIPFTGKGYVLGETSNFSSGKCITSHAINESQEPLSQDHSANALRPHSKTE
VKFEQNGPSKKTSVASPVLSTSHQNVLSNYFSKVSVASSKAFRSVSGSPVKSLTVGDSTT
KSVSAGSQRRVTSSRTSLRNSLKAMESTYVTVPQDAGGPEGKLPSKRPRIEDKTFFDLFF
IKKEQAQSGGGDVTSSSHPPAAAQSPSGASGQSRVVHCPVCQDEVSETQINEHLDWCLER
DSTQVKS
|
| External Links |
|---|
| GenBank ID Protein
| ABQ12938.1 |
| UniProtKB/Swiss-Prot ID
| A5D979 |
| UniProtKB/Swiss-Prot Entry Name
| SPRTN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT030498 |
| GeneCard ID
| SPRTN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
