<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:32:07 UTC</creation_date>
  <update_date>2020-05-20 21:52:43 UTC</update_date>
  <accession>BMDBP02555</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>LGI1</gene_name>
  <general_function>Involved in protein binding</general_function>
  <specific_function>Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0003339</accession>
      <name>D-Glutamic acid</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>26</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1602 bp
ATGGAATCAGAGAGAAGCCAAAGGATGGGAAATGCCTGCATCCCCCTGAAAAGAATTGCT
TATTGCCTATGTCTCTTATCTGCGCTTCTGCTGACTGAGGGGAAGAAACCAGCAAAGCCA
AAATGCCCTGCCGTGTGTACTTGTACCAAAGATAATGCCTTATGTGAGAATGCCAGATCC
ATTCCACGCACCGTTCCTCCTGACGTTATCTCATTGTTATTCACATCGAACTCCTTTGAT
GTGATCAGTGATGATGCTTTCATTGGTCTCCCACATCTAGAGTATTTATTCATAGAAAAC
AACAATATCAAGTCCATTTCAAGACATACTTTCCGAGGACTAAAGTCTTTAATTCACCTG
AGCCTTGCAAACAACAATCTCCAGACTCTCCCAAAAGATATTTTCAAAGGCCTGGATTCT
TTAACAAATGTTGACCTGAGAGGTAATTCATTTAATTGTGACTGTAAACTGAAGTGGCTG
GTGGAATGGCTAAGCCACACCAATGCAACTGTCGAAGACATCTATTGTGAAGGCCCTCCA
GAATACAAGAAGCGCAAAATCAATAGTCTTTCCTCCAAGGATTTTGATTGCATCATTACA
GAGTTTGCAAAGTCTCAAGACCTGCCTTATCAATCACTGTCCATAGACACTTTTTCTTAT
ATGAACGATGAGTATGTCGTCATCGCTCAGCCTTTTACTGGAAAGTGCATTTTCCTTGAA
TGGGACCATGTAGAAAAGACCTTCCGGAATTATGACAACATCACAGGCACGTCCACGGTA
GTGTGCAAGCCTATAGTCATTGAAACTCAGCTCTATGTCATTGTGGCCCAGCTGTTTGGC
GGCTCTCACATCTATAAGAGAGACAGCTTTGCAAATAAATTCATAAAAATCCAGGATATT
GAAATCCTCAAAATCCGAAAACCCAATGACATTGAAACATTCAAGATTGAAAACAACTGG
TACTTCGTTGTGGCTGACAGTTCAAAAGCTGGTTTCACTACCATTTATAAATGGAACGGA
AATGGATTCTACTCCCATCAATCTTTACATGCATGGTACAGGGATACTGATGTGGAATAT
CTAGAAATAGCCAGAACACCTCAGACTCTCAGAACGCCTCATTTAATACTGTCCAGTAGT
TCCCAGCGTCCTGTCATTTATCAGTGGAACAAAGCAATACAATTATTCACTAACCAAACT
GACATCCCTAACATGGAGGATGTATATGCCGTTAAGCACTTCTCAGTGAAAGGCGATGTG
TACATTTGCTTGACAAGATTCATTGGTGATTCCAAAGTAATGAAATGGGGAGGCTCCTCA
TTTCAGGATATTCAGAGGATGCCATCACGAGGATCCATGGTGTTCCAGCCTCTTCAGATA
AATAACTATCAATATGCAATTCTTGGAAGTGATTATTCCTTTACTCAAGTGTATAACTGG
GATGCAGAGAAAGCCAAATTTGTGAAATTTCAGGAATTAAATGTTCAGGCACCAAGATCA
TTCACGCATGTGTCCATTAATAAACGCAATTTTCTTTTTGCTTCCAGTTTTAAGGGAAAC
ACACAGATTTACAAACATGTCATAGTTGACTTAAGCGCATGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>533</residue_number>
    <molecular_weight>61161.0</molecular_weight>
    <theoretical_pi>8.3</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>53-73</region>
      <region>80-98</region>
      <region>118-139</region>
      <region>146-165</region>
      <region>171-193</region>
      <region>205-223</region>
      <region>229-247</region>
      <region>281-299</region>
      <region>342-370</region>
      <region>382-405</region>
      <region>411-436</region>
      <region>457-474</region>
      <region>480-500</region>
    </transmembrane_regions>
    <signal_regions>
      <region>1-34</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Leucine-rich glioma-inactivated protein 1
MESERSQRMGNACIPLKRIAYCLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARS
IPRTVPPDVISLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHL
SLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLSHTNATVEDIYCEGPP
EYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYMNDEYVVIAQPFTGKCIFLE
WDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIKIQDI
EILKIRKPNDIETFKIENNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEY
LEIARTPQTLRTPHLILSSSSQRPVIYQWNKAIQLFTNQTDIPNMEDVYAVKHFSVKGDV
YICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNW
DAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAX08851.1</genbank_protein_id>
  <uniprot_id>Q5E9T6</uniprot_id>
  <uniprot_name>LGI1_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BT020834</genbank_gene_id>
  <genecard_id>LGI1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
